Background: Mantle cell lymphoma (MCL) is an aggressive disease with short median survival. Molecularly, MCL is defined by the t(11;14) translocation leading to overexpression of the CCND1 gene. However, recent data show that the neural transcription factor SOX11 is a disease defining antigen and several involved signaling pathways have been pin-pointed, among others the Wnt/β-catenin pathway that

The associations of body mass index (BMI) and other anthropometric measurements with lung cancer were examined in 348,108 participants in the European Investigation Into Cancer and Nutrition (EPIC) between 1992 and 2010. The study population included 2,400 case patients with incident lung cancer, and the average length of follow-up was 11 years. Hazard ratios were calculated using Cox proportional

Synucleinopthies are neurodegenerative diseases characterised by the formation of α-synuclein-rich intracellular inclusions in neurons and glia. Traditionally, animalmodels and immortalized cell lines have been used to investigate why and how theseinclusions form, and how they impact on cellular function. Recent advances incellular reprogramming and directed differentiation have enabled the genera

Den här rapporten analyserar bedömningsprocessen och bedömningskriterier i tillsättningsärenden av universitetslektorer vid Ekonomihögskolan vid Lunds universitet med särskilt fokus på sju tillsättningsärenden av universitetslektorer vid den Företagsekonomiska institutionen. Rapporten gör en genomgång av regelverket och lokala föreskrifter kring tillsättningar av universitetslektorer samt hur man

Centralt för ett välfungerande och effektivt välfärdssystem är att förmånerna når ut till de människor de är avsedda för. Genom att sätta fokus på ett utslag av så kallad non-take up - nämligen kvinnors beslut att avstå från mammografiscreening - diskuterar denna artikel beslutsprocessen i förhållande till levnadsvillkorens betydelse för ageranden i hälsofrågor ställt i ljuset av välfärdsstatens f

According to virtually all international corruption rankings, Sweden is one of the top performing countries with very few exposed incidents of corruption. But does this automatically imply that it can be declared a perfectly ‘healthy patient’? By extensively reviewing existing research and adding empirical sets of data, the authors of A Clean House? shed light on shady corners of the Swedish case.

There is a clear trend in rich countries that despite rising incomes and living standards, the gap between rich and poor is widening. What does this mean for our health? Does increasing income inequality affect outcomes such as obesity, life expectancy and subjective well-being? Are rich and poor groups affected in the same ways? This book reviews the latest research on the relationship between in

Ethical consumption, that is, to make certain consumption choices due to personal moral beliefs and values is a growing trend and market. In this article we analyze three ethical smartphone apps developed and marketed in order to help consumers to make ethical product choices: for example, where to find the nearest café selling Fair Trade coffee, whether the salmon in the store is red-listed or if

During thermomechanical processing of metals, changes occur in the microstructure of the material which affect its macroscopic properties. By understanding these transformations in the microstructure, it becomes possible to design the processes in a way which yields the desired properties in the finished product. For this purpose, computer simulation plays an increasingly important role.The presen