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Refined modelling of the short-T2 signal component and ensuing detection of glutamate and glutamine in short-TE, localised, 1H MR spectra of human glioma measured at 3T

Short-TE 1H MRS has great potential for brain cancer diagnostics. A major difficulty in the analysis of the spectra is the contribution from short-T2 signal components, mainly coming from mobile lipids. This complicates the accurate estimation of the spectral parameters of the resonance lines from metabolites, so that a qualitative to semi-quantitative interpretation of the spectra dominates in pr

A European multicentre survey of impulse control behaviours in Parkinson's disease patients treated with short- and long-acting dopamine agonists

Background and purpose: Impulse control disorders (ICDs) in Parkinson's disease (PD) are associated primarily with dopamine agonist (DA) use. Comparative surveys of clinical occurrence of impulse control behaviours on longer acting/transdermal DA therapy across age ranges are lacking. The aim of this study was to assess the occurrence of ICDs in PD patients across several European centres treated

Gastrointestinal and liver disease in Adult Life After Childhood Cancer in Scandinavia : A population-based cohort study

Survival after childhood cancer diagnosis has remarkably improved, but emerging evidence suggests that cancer-directed therapy may have adverse gastrointestinal late effects. We aimed to comprehensively assess the frequency of gastrointestinal and liver late effects among childhood cancer survivors and compare this frequency with the general population. Our population-based cohort study included a

Operationalizing Ecosystem-Based Adaptation: Harnessing Ecosystem Services to Buffer Communities against Climate Change

Ecosystem-based approaches for climate change adaptation are promoted at international, national, and local levels by both scholars and practitioners. However, local planning practices that support these approaches are scattered, and measures are neither systematically implemented nor comprehensively reviewed. Against this background, this paper advances the operationalization of ecosystem-based a

From Risk Governance to City-Citizen Collaboration: Capitalizing on Individual Adaptation to Climate Change

Urban societies are increasingly affected by climatic variability and extremes. In theory, adaptation policy creates the conditions needed to support autonomous adaptation – or deliver public adaptation if autonomous adaptation fails to develop. However, little attention has been given to autonomous adaptation by private households and individuals, and how it is taken into account in cities’ strat

Detailed gene dose analysis reveals recurrent focal gene deletions in pediatric B-cell precursor acute lymphoblastic leukemia

To identify copy number alterations (CNAs) in pediatric B-cell precursor acute lymphoblastic leukemia (BCP ALL), array comparative genomic hybridization was performed on 50 cases; detected CNAs were validated in a cohort of 191 cases analyzed by single nucleotide polymorphism arrays. Apart from CNAs involving leukemia-associated genes, recurrent deletions targeting genes not previously implicated