Background and aim: Generic drugs contain the same active ingredients as brand- name drugs, with the advantage of much lower costs. The aim of this thesis was to contribute new knowledge to the ongoing debate on the safety of generic antiseizure drug (ASD) substitutions. There was a particular emphasis on the pharmacokinetic and clinical outcomes.Methods: In papers I and II, a prospective naturali

Background: Effort rupture of the esophagus or Boerhaave’s syndrome is a rare entity, and prognosis is largely dependent on early diagnosis and treatment. Recurrent effort ruptures are very rare, only reported in a few case reports in English literature. We present a case with a third time effort rupture, and to the best of our knowledge there are no such previous publications. Furthermore, the pr

A novel method to enhance the heat transfer on the internal tip surface of gas turbine blades was developed. Effects of delta-winglet vortex generators (DWVG) and their angle of attack on the vortical structures and mechanism of enhanced heat transfer were investigated. Seven different angles of attack were considered: 0°, 15°, 30°, 45°, 60°, 75°, and 90°. The Reynolds number varies from 10,000 to

An extensive and reliable electricity grid is essential for all sectors of society. In parts of Sweden, the electricity grid has been suffering from a lack of capacity. This is something affecting all sectors and all people in these regions. The capacity problems have however so far mainly been analyzed in a technical system perspective, focusing on incumbent actors, whereas other actors have beenAn extensive and reliable electricity grid is essential for all sectors of society. In parts of Sweden, the electricity grid has been suffering from a lack of capacity. This is something affecting all sectors and all people in these regions. The capacity problems have however so far mainly been analyzed in a technical system perspective, focusing on incumbent actors, whereas other actors have been

Introduction: Synaptic dysfunction and degeneration is one of the earliest events in Alzheimer's disease (AD) and the best correlate of cognitive decline. Thus, identification and validation of biomarkers reflecting synaptic degeneration to be used as prognostic biomarkers are greatly needed.Method: Solid-phase extraction and parallel reaction monitoring mass spectrometry were used to quantify 17

Aims: This article discusses the situation of the social medicine specialty in Skåne, southern Sweden with the aim of understanding the long-term trends of this medical specialty in Skåne and its relation to research in social medicine. Results: In the 1950s to 1980s, there was a balance between clinical and preventive practice, and research. This balance was maintained in the 1980s to early 2000s

Phosphorus induced eutrophication of freshwaters is one of the great global challenges. As the critical threshold concentration for eutrophication is very low, there is a strong need for development of phosphate sorbents with high affinity and selectivity. Single sheet iron oxide (SSI), a nanomaterial prepared from oxidation and exfoliation of layered iron(II)-iron(III) hydroxide (green rust), is

Poverty in Contemporary Economic Thought aims to describe and critically examine how economic thought deals with poverty, including its causes, consequences, reduction and abolition. This edited volume traces the ideas of key writers and schools of modern economic thought across a significant period, ranging from Friedrich Hayek and Keynes to latter-day economists like Amartya Sen and Angus Deaton

Fruit and vegetables are vital components of a healthy diet, and international strategies to encourage their consumption are in place (FAO/WHO, 2005). Ready-to-eat (RTE) leafy green vegetable products have exploded in popularity, and are a convenient and attractive way to add greens to the plate. Unfortunately, sales numbers are accompanied by increasing numbers of food-borne illness outbreaks.Thi

This introduction presents an overview of the key concepts discussed in the subsequent chapters of this book. The book provides presentation of the work of the economists who received the 2019 Prize in Economic Sciences in Memory of Alfred Nobel. It deals almost exclusively with poverty within a nation, with the situation of individuals in society. The book explores the perspective to a comparison

Objective Prematurity is a major risk factor for retinopathy of prematurity (ROP). We aimed to elucidate ROP prevalence, treatment and retreatment in infants born before 24 gestational age (GA) weeks in a Swedish cohort. Methods and analysis Infants with completed ROP screening, born at

Hematopoietic stem and progenitor cells (HSPCs) in the fetus and the adult possess distinct molecular signatures that regulate cell fate and change their susceptibility to initiation and progression of hematological malignancies, such as leukemia. It is well established that fetal and adult hematopoiesis are functionally distinct processes; however, the underlying molecular mechanisms that govern

This paper elucidates the influence of Hassan al-Banna, the founder of the Muslim Brotherhood, on Hussein Al-Houthi, the founder of the Houthi movement in Yemen, by comparing al-Houthi’s Malazim (lectures) to al-Banna’s Rasa'il (messages)

Key message: Dynamic global vegetation models are key tools for interpreting and forecasting the responses of terrestrial ecosystems to climatic variation and other drivers. They estimate plant growth as the outcome of the supply of carbon through photosynthesis. However, growth is itself under direct control, and not simply controlled by the amount of available carbon. Therefore predictions by cu

PurposeThe paper aims to examine some economical, political and health system indicators on the transmission of the COVID-19 transmission within the national system. The main objective is to investigate what are the most effective indicators which have led to the declared numbers by countries.Design/methodology/approachThis study combined multiple sets of data to describe best the economical statu

The demand for large-scale and long-term information on tree growth is increasing rapidly as environmental change research strives to quantify and forecast the impacts of continued warming on forest ecosystems. This demand, combined with the now quasi-global availability of tree-ring observations, has inspired researchers to compile large tree-ring networks to address continental or even global-sc