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Prostate cancer (PC) develops from an androgen-dependent tissue that contains androgen receptors in both the stromal and glandular compartments. Surgical removal of the prostate may cure the patient, but if metastatic spread has occurred, androgen suppression therapy is the standard treatment. However, most men will eventually fail this therapy and develop recurrent androgen-independent disease, f
While only about 30% of California's usable water storage capacity lies at higher elevations, high-elevation (above 300 m) hydropower units generate, on average, 74% of California's in-state hydroelectricity. In general, high-elevation plants have small man-made reservoirs and rely mainly on snowpack. Their low built-in storage capacity is a concern with regard to climate warming. Snowmelt is expe
A search for the production of single-top-quarks in association with missing energy is performed in proton-proton collisions at a centre-of-mass energy of [Formula: see text] with the ATLAS experiment at the large hadron collider using data collected in 2012, corresponding to an integrated luminosity of [Formula: see text] fb[Formula: see text]. In this search, the [Formula: see text] boson from t
Since the early 1980s remarkable progress has been made in understanding the role of the HER2 locus in carcinogenesis, but many details of its regulatory network are still elusive. We recently reported the finding of 367 new human microRNA (miRNA) genes of which one, mir-4728, is encoded in an intron of the HER2 gene. Here, we confirm that the HER2 oncogene is a bi-functional locus encoding the me
The need for higher yielding and better-adapted crop plants for feeding the world's rapidly growing population has raised the question of how to systematically utilize large genebank collections with their wide range of largely untouched genetic diversity. Phenotypic data that has been recorded for decades during various rounds of seed multiplication provides a rich source of information. Their us
The structural/phase behaviour of self-assembled lyotropic liquid crystals formed in mixtures of a phospholipid and alpha-tocopherol (vitamin E) is presented.
ALICE is the LHC experiment dedicated to the study of heavy-ion collisions at extreme energy density where formation of the quark–gluon plasma is expected. Among the different observables, open heavy flavors and heavy quarkonia states are especially relevant. Indeed they will be copiously produced and they will provide sensitive information on the collision. In this paper, the ALICE muon spectrome
Resonance Raman spectra (RRS) of Mg-tetraazaporphyrin (1) and Mg-tetraazaoctaphenylporphyrin (2) in solid crystal powder at ambient temperature and different excitation wavelengths were recorded and analyzed. FTIR spectra of 1 and 2 in solid crystal powder were also measured. On the basis of DFT quantum-chemical calculations the frequencies, maximum amplitude changes for internal coordinates, and
Binding energy shifts between free and solid state atoms for K 2p and Rb 3d photolines have been determined by measuring the vapor and solid state spectra simultaneously in similar experimental conditions applying synchrotron radiation excited photoelectron spectroscopy. This method has the important benefit that the work function is not needed to correct for different reference energy levels, the
Psoriasis is a complex genetic disease of unresolved pathogenesis with both heritable and environmental factors contributing to onset and severity. In addition to a disfiguring skin inflammation, approximately 10-40% of psoriasis patients suffer from destructive joint involvement. Previously, we reported that the CD18 hypomorphic PL/J mouse carrying a mutation resulting in reduced expression of th
Lack of straightness in timber is the most frequent complaint regarding solid (and laminated) timber products worldwide. Nowadays, customers demand higher quality in the shape stability of wood products than they did earlier. The final distortion of timber boards is mostly caused by moisture-related stresses in wood (drying distortions) and growth-related stresses (distortions appearing when logs
The title compound, Ca2Pd3Ge, was prepared as a part of a systematic investigation of the Ca-Pd-Ge ternary phase diagram. The structure was determined and refined from single-crystal X-ray diffraction data. It is a new fully ordered ternary Laves phase with the space group R-3m, Z=3, a=5.6191 (5) angstrom, c=12.1674 (7) angstrom. wR(2)=0.054 (all data) and is isostructural to Mg2Ni3Si (Noreus et a
Purpose – The purpose of this paper is to revise the concept of positioning to differentiate between fundamental approaches to it and chart a scheme of schools of positioning. Design/methodology/approach – An extensive literature review traces the roots and evolution of the concept. Two approaches to positioning are explored and related to the paradigms of market and brand orientation. Based on c
The aim of this study was to investigate how physico-chemical properties of two dietary fibres, guar gum and pectin, affected weight gain, adiposity, lipid metabolism, short-chain fatty acid (SCFA) profiles and the gut microbiota in male Wistar rats fed either low- or high-fat diets for three weeks. Both pectin and guar gum reduced weight gain, adiposity, liver fat and blood glucose levels in rats
Popular Abstract in Swedish Typ 2 Diabetes (T2D) räknas som en folksjukdom i Sverige vilket innebär att den är så vanlig att minst 4 % av befolkningen är drabbad. Förekomsten av diabetes ökar lavinartat över hela världen och man beräknar att så många som 300 miljoner människor har diabetes idag. Socker är en livsviktig energikälla, men lagom är bäst Socker i mat förs ut till blodet och används soType 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts). The aim of this thesis has been to investigate functional and genetic events that
Bi-spectral beam extraction combines neutrons from two different kinds of moderators into one beamline, expanding the spectral range and thereby the utilization of an instrument. This idea can be realized by a mirror that reflects long wavelength neutrons from an off-axis colder moderator into a neutron guide aligned with another moderator emitting neutrons with shorter wavelengths which will be t
Alamethicin is a membrane-active peptide isolated from the beneficial root-colonising fungus Trichoderma viride. This peptide can insert into membranes to form voltage-dependent pores. We have previously shown that alamethicin efficiently permeabilises the plasma membrane, mitochondria and plastids of cultured plant cells. In the present investigation, tobacco cells (Nicotiana tabacum L. cv Bright
