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Context: Castration-resistant prostate cancer (CRPC) refers to patients who no longer respond to surgical or medical castration. Standard treatment options are limited. Objective: To review the concepts and rationale behind targeted agents currently in late-stage clinical testing for patients with CRPC. Evidence acquisition: Novel targeted therapies in clinical trials were identified from registri
To improve the biologic understanding of the Polycystic Ovarian Syndrome (PCOS) condition by examining the circadian variation and relationship between Anti Müllerian Hormone (AMH), gonadotropins and ovarian steroids in PCOS patients compared to normally ovulating and menstruating women. By comparing the pattern of co-variation between AMH and Luteinizing Hormone, two compounds closely linked to h
Angiogenesis is one of the hallmarks of breast cancer. The status of angiogenesis is important in therapy choice. Spider telangiectasias (telangiectasias) may reflect an increased ability to form vessels. Our first aim was to identify patient and tumor characteristics associated with the occurrence of telangiectasias at the time of breast cancer diagnosis. The second aim was to study the overall s
Survival following a diagnosis of multiple myeloma (MM) varies between patients and some of these differences may be a consequence of inherited genetic variation. In this study, to identify genetic markers associated with MM overall survival (MM-OS), we conduct a meta-analysis of four patient series of European ancestry, totalling 3,256 patients with 1,200 MM-associated deaths. Each series is geno
The overall aim was to describe and compare functional ability and health complaints of older people receiving municipal care in relation to housing and informal care, and factors associated with medical health care, municipal care and informal care. Further, the aim was to investigate agreement in needs assessments between personnel and older people and to investigate care satisfaction and health
BACKGROUND/OBJECTIVES: Heavy alcohol drinking is a risk factor of colorectal cancer (CRC), but little is known on the effect of polymorphisms in the alcohol-metabolizing enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) on the alcohol-related risk of CRC in Caucasian populations. SUBJECTS/METHODS: A nested case-control study (1269 cases matched to 2107controls by sex, age, stu
Intracellular membrane fusion is coordinated by membrane-anchored fusion proteins. The cytosolic domains of these proteins form a specific complex that pulls the membranes into close proximity. Although some results indicate that membrane merger can be accomplished solely on the basis of proximity, others emphasize the importance of bilayer stress exerted by transmembrane peptides. In a reductioni
Suicide is a major global health problem imposing a considerable burden on populations in terms of disability-adjusted life years. There has been an increasing trend in fatal and attempted suicide in Iran over the past few decades. The aim of the current study was to assess overall, gender and social inequalities across Iran's provinces during 2006-2010.
Recension av Barbro Eberan, Förlorade generationer? Tyskarna och skuldfrågan.
The effects induced by Na deposited on furnace grown graphene on SiC(0001) and after subsequent annealing are investigated using LEEM, mu-LEED, mu-PES and XPEEM. Intercalation in between carbon layers and at the interface is observed to occur both on the 1 ML and 2 ML areas directly after Na deposition. Annealing at a temperature around 100 degrees C is found to strongly promote Na intercalation.
In this paper a count data regression model accounting for endogenous censoring with household specific censoring thresholds is presented. The presented modelling approach is utilized in an analysis of household choice of total number of nights to spend on monthly recreational trips. The empirical study reveals that the suggested approach is feasible and that accounting for endogenous censoring gi
Melangyna pavlovskyi (Violovitsh, 1956) has been found breeding in Denmark. The species is recorded from four localities on Zealand, and it is established on at least one of these. It is new to the European fauna. A redescription of M. pavlovskyi based on the external characters and an updated key to the NW European species of Melangyna are presented.
Background and purpose The Hansson Twin Hook (HTH) is an alternative to the lag screw in the treatment of trochanteric fractures. In osteoporotic bone, mechanical tests have indicated that the HTH has better fixation properties than the lag screw. We evaluated the fixation stability of the HTH in a large series of elderly patients with trochanteric fractures. Many surgeons were involved in assessm
We consider the following signaling game. Nature plays first from the set {1,2}{1,2}. Player 1 (the Sender) sees this and plays from the set {A,B}{A,B}. Player 2 (the Receiver) sees only Player 1’s play and plays from the set {1,2}{1,2}. Both players win if Player 2’s play equals Nature’s play and lose otherwise. Players are told whether they have won or lost, and the game is repeated. An urn sche
This paper presents a novel online approach of merging multiple different predictors of time-varying dynamics into a single optimized prediction. Different predictors are merged by recursive weighting into a single prediction using regularized optimization. The approach is evaluated on two different cases of data with shifting dynamics; one example of prediction using several approximate models of
The purpose of this study is to investigate how people express religious and national identities in the conflict-ridden Patani region of southern Thailand. In a historical framework of disputes over territory and political legitimacy, where identities have developed in response to an emerging Thai nation, it is of relevance to understand the dynamics of these identities and to disclose how local p
This Letter presents the results of a direct search with the ATLAS detector at the LHC for a Standard Model Higgs boson of mass 110 <= m(H) <= 130 GeV produced in association with a W or Z boson and decaying to b (b) over bar. Three decay channels are considered: ZH -> l(+)l(-)b (b) over bar, WH -> lvbb (b) over bar and ZH -> v (v) over bar(b) over bar where l corresponds to an electron or a muon.
Background: Sex pheromones are essential in moth mate communication. Information on pheromone biosynthetic genes and enzymes is needed to comprehend the mechanisms that contribute to specificity of pheromone signals. Most heliothine moths use sex pheromones with (Z)–11–hexadecenal as the major component in combination with minor fatty aldehydes and alcohols. In this study we focus on four closely
