Sökresultat

The vast majority of patients with pancreatic cancer present with unresectable disease and precision medicine is lagging behind. Circulating tumor DNA (ctDNA) has emerged as a promising tool, both as a proxy for tumor burden and for capturing tumor heterogeneity, but optimal gene panels and prognostic cutoffs remain to be determined. Herein, we applied ultra-deep ctDNA sequencing using a customize

OBJECTIVE AND DESIGN: The objective was to determine the association between serum IgE levels and the infiltration order of T lymphocytes and macrophages in pancreatic islets in relation to the loss of insulin and glucagon cells in presymptomatic congenic BB Gimap5-DP (Diabetes Prone) rats.MATERIAL: Congenic prediabetes BB Gimap5-DP and control Gimap5-DR (Diabetes Resistant) rats were followed eve

BACKGROUNDDistinguishing wide complex tachycardia (WCT) as ventricular tachycardia (VT) or supraventricular WCT (SWCT) is critical yet challenging. Manual ECG algorithms require substantial expertise and are inconsistently applied, and contemporary computerized ECG interpretation (CEI) systems often return only a generic “wide complex tachycardia” label. Novel machine learning–based ECG models (So

This study examines how two instructional conditions - explicit and implicit narrative instruction - were implemented in Swedish preschools, drawing on principles from implementation science. Data from 21 preschool departments—including video recordings, teacher interviews, and survey data - were analyzed using a mixed-methods approach. The implicit approach (HINT), focusing on shared reading and

5-15% of all colorectal cancers (CRCs) are mucinous. Mucinous CRCs are associated with an inhibited response to standard adjuvant and neoadjuvant therapies. Serine-Arginine Protein Kinase 1 (SRPK1) is an enzyme, which modulates the activity of multiple splicing factors. SRPK1 under-expression is associated with resistance to platinum-based chemotherapeutic agents in multiple tumor types. The objec

Thanks to its ability to form a lattice of self-ordered nanosized pores, nanoporous anodic aluminum oxide (NP-AAO) is a promising material with diverse applications, for example, as membrane for the controlled deposition of catalysts. NP-AAO is obtained by the anodization of an aluminum substrate under specific pH and voltage conditions. However, the growth mechanism of the oxide is still under de

Provision of assistive technologies (AT) is strongly connected to applying a person-centred approach, with focus on exploring the person’s individual abilities, needs and desires, to enable provision of matching AT. In the process of provision, it is also important to assess and facilitate the person’s understanding of how to use the AT, to enhance optimal usage and enable AT integration in everyd

By combining the quantitative advantage of laser absorption spectroscopy and the superior spatiotemporal resolution of high-speed microscopic imaging, we report, for the first time, the transient aluminum monoxide (AlO) concentration distribution around a burning micro-sized aluminum droplet in water-vapor-rich ambient. Arrangement of two lasers at resonant and non-resonant wavelengths, respective

Passivity refers to spontaneous formation of a passive film on the surface of metals. High stability of the passive film on advanced alloys relies on the repassivation ability of the alloys in corrosive environments. Two Ni-base superalloys (Ni-22Cr-9Mo-5Fe-2Nb and Ni-18Cr-3Mo-20Fe-5Nb) are studied to elucidate the mechanism of repassivation through a combination of multimodal in-situ synchrotron

In Sweden, the statutory audit extends beyond the financial statement audit. It mandates an audit of the company’s administration by the board and the managing director (management audit). Despite being a national tradition since the mid seventeenth century and resisting various harmonisation efforts, the practice remains under-researched in accounting history. This study aims to analyse the devel

The C-14 results from the study demonstrate that, although the liquid discharges from the Ringhals Nuclear Power Plant (NPP) are assumed to be small compared to the total operational C-14 releases, the resulting C-14 levels in marine biota can be substantially higher than in terrestrial biota. The fndings indicate that the chemical speciation of discharged C-14 plays a critical role in its transfe

Digitalization is transforming the tax landscape, reshaping the operations of tax departments, authorities, and professionals. With rapid digital advancement, there has been a shift toward real-time reporting, e-invoicing, and greater reliance on digital data. This change is driven by investments in data analytics, robotic process automation, cloud platforms, and, more recently, artificial intelli

Forest disturbances can cause shifts in boreal vegetation cover from predominantly evergreen to deciduous trees or non-forest dominance. This, in turn, impacts land surface properties and, potentially, regional climate. Accurately considering such shifts in future projections of vegetation dynamics under climate change is crucial but hindered (e.g., uncertainties in future disturbance regimes). In

Based on the experiences from a social innovation process ofSwedish preschool remodelling – aiming to enhance equal and inclusivelearning and play – the study investigates socio-material dimensions incomplex multi-actor/level (ex)change. Previous studies on systemic changethrough social innovation ecosystems help reveal dynamics and challenges inthe coordination of varying logics and interests amo

Objective: Family members of a person with drug addiction often experience negative impacts on their lives and face barriers to seeking professional support. More knowledge is needed about such barriers so they can be reduced. This article examines the help-seeking experiences of parents of adult children with drug addiction, a group that has received little attention in research. Method: We condu

Background: In opioid replacement therapy (ORT), drug testing is performed continuously to ensure that patients are taking their prescribed medication, and to detect whether they have taken other, non-prescribed, substances. Typically, supervised urine testing is conducted, and in Sweden such testing is often an ORT precondition. Aim: This study investigates ORT patients’ experiences of and views