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Model-based animal cognition slips through the sequence bottleneck

In a recent article in TiCS, Lind and Jon-And [1] argued that the sequence memory of animals constitutes a cognitive bottleneck, the ‘sequence bottleneck’, and that mental simulations require faithful representation of sequential information. They therefore concluded that animals cannot perform mental simulations, and that behavioral and neurobiological studies suggesting otherwise are best interp

An eternally grateful refugee? : Silences in Swedish public discourse and the (de)historicization of Polish-Swedish activist Ludwika Broel-Plater

This chapter examines how the history and legacy of Polish-Swedish activist Ludwika Broel-Plater have been obscured in Swedish public discourse, in which she is recognized mainly as a passive and grateful recipient of Swedish humanitarianism. The first part of the chapter examines silences that have entered narrative constructions in Swedish public discourse about survivors who came to Sweden as r

Infections, antigen-presenting cells, T cells, and immune tolerance : their role in the pathogenesis of immune thrombocytopenia

In the last 20 years, many publications have shed new light on the complex immunopathogenesis of immune thrombocytopenic purpura. They are associated with 3 interrelated areas of environmental autoimmunity, for example, infectious influences, antigen-presenting cell (APC) function, and T-cell abnormalities, particularly tolerance induction. This article highlights the recent literature and argues

Management of acute mesenteric ischaemia in adult patients : a systematic review and meta-analysis

Background: Guidance on managing acute mesenteric ischaemia (AMI) is largely based on expert opinion and retrospective studies pooling different subtypes of AMI. In clinical practice, management strategy is often selected based on the patient’s severity of illness, whereas randomized controlled trials or even adjusted analyses comparing different strategies are rarely available. We aimed to perfor

Validation of POD24 as a robust early clinical indicator of poor survival in mantle cell lymphoma from 1280 patients on clinical trials, a LYSA study

In mantle cell lymphoma, early progression of disease has been associated with short overall survival. The impact of clinical, pathological, and treatment strategies on the risk of early relapse has not been assessed in a large cohort of patients. We performed a pooled analysis of patients recruited in France from six randomized first-line MCL trials. Among 1386 treated MCL patients, 1280 were eva

Flexible fabrication of aligned multi-nanowire circuits for on-chip prototyping

Circuits of multiple deterministically positioned semiconductor nanowires (NWs) is the basis of many devices for photonic, quantum, or conventional transistor applications. To explore and iterate on the design of larger circuits, the means to quickly place and electrically evaluate NWs at target locations must be developed. We propose and demonstrate a multi-NW circuit building concept on SiO2/Si

Simulating mismatch between calibration and target population in AI for mammography the retrospective VAIB study

AI cancer detection models require calibration to attain the desired balance between cancer detection rate (CDR) and false positive rate. In this study, we simulate the impact of six types of mismatches between the calibration population and the clinical target population, by creating purposefully non-representative datasets to calibrate AI for clinical settings. Mismatching the acquisition year b

Meta-analysis of uveal melanoma genome-wide association studies identifies novel risk loci and population effect size heterogeneity

Uveal melanoma (UM) is a rare but frequently metastasizing cancer. Genome-wide association studies have identified three common genome-wide significant germline risk loci. Here, we perform a genome-wide association study on 401 new cases and conduct a meta-analysis with three independent previously published cohorts for a total sample size of 2,426 cases. We confirm the three previously identified