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AimThe aim was to explore the ambulance service as experienced by present and former employees.BackgroundOver the last decade, the number of ambulance assignments has increased annually by about 10%, and as many as 50% of all ambulance assignments are considered non-urgent. This raises questions about which assignments the Ambulance Service (AS) is supposed to deal with.Design/methodData were coll

Viktor Yushchenko’s 2010 designation of Stepan Bandera, the war‐time leader of the most radical and violent branch of the Ukrainian far right, as a national hero constituted, in many ways, the climax of the third post‐Soviet Ukrainian president’s instrumentalization of history. Yushchenko’s political use of history triggered sharply polarized, and often emotional discussions of Bandera’s role in h

Endospore cortex peptidoglycan synthesis is notrequired for bacterial growth but essential for endo-spore heat resistance. It therefore constitutes anamenable system for research on peptidoglycan bio-genesis. The Bacillus subtilis sporulation-specificclass B penicillin-binding protein (PBP) SpoVD andmany homologous PBPs contain two conserved cys-teine residues of unknown function in the transpepti

We are motivated by a tantalizing open question in exact algorithms: can we detect whether an n-vertex directed graph G has a Hamiltonian cycle in time significantly less than 2^n? We present new randomized algorithms that improve upon several previous works: 1. We show that for any constant 0

Succinate:quinone reductase catalyzes electron transfer from succinate to quinone in aerobic respiration. Carboxin is a specific inhibitor of this enzyme from several different organisms. We have isolated mutant strains of the bacterium Paracoccus denitrificans that are resistant to carboxin due to mutations in the succinate:quinone reductase. The mutations identify two amino acid residues, His228

Arsenate reductase (AR) in B. subtilis is encoded by the chromosomal arsC gene. Together with arsB and arsR, arsC participates in detoxification processes for the arsenate and arsenite ions. Full-length arsenate reductase without any modification has been expressed in Escherichia coli and purified in a soluble form. The recombinant protein has been crystallized at 277 K using polyethyleneglycol (P

Succinate:quinone reductases are membrane-bound enzymes that catalyze electron transfer from succinate to quinone. Some enzymes in vivo reduce ubiquinone (exergonic reaction) whereas others reduce menaquinone (endergonic reaction). The succinate:menaquinone reductases all contain two heme groups in the membrane anchor of the enzyme: a proximal heme (heme b(P)) located close to the negative side of

We have cloned an Enterococcus faecalis gene cluster, cydABCD, which when expressed in Bacillus subtilis results in a functional cytochrome bd terminal oxidase. Our results indicate that E. faecalis V583 cells have the capacity of aerobic respiration when grown in the presence of heme.

Purpose: Although advances in Hodgkin lymphoma (HL) treatment have led to improved disease-free survival, this has been accompanied by an increased risk of second cancers. We sought to quantify the second cancer risks and to investigate the impact of family history. Patients and Methods: Using the Swedish Family-Cancer Project Database, we identified 9,522 individuals with primary HL diagnosed bet

Background: Although routine administration of pharmacologic sedation or analgesia during mechanical ventilation in preterm neonates is not recommended, its use in clinical practice remains common. Alpha-2 agonists, mainly clonidine and dexmedetomidine, are used as adjunctive (or alternative) sedative agents alongside opioids and benzodiazepines. Clonidine has not been systematically assessed for

Papillorenal syndrome (PAPRS; Mendelian Inheritance in Man [MIM] 120330) is an autosomal dominant disease characterised by the presence of congenital renal and optic nerve abnormalities associated with mutations of the PAX2 gene. In this article, the authors present four patients with PAPRS who are carriers of three new PAX2 mutations, as well as another patient with a possible non-pathogenic vari

Background: Pregnant women with depression and/or anxiety prior to pregnancy are at higher risk of preterm birth, breastfeeding problems, postpartum depression, and disruption of the mother-infant attachment. It is well documented that exercise improves psychological well-being in nonpregnant subjects with symptoms of depression. However, in only a few small studies have researchers examined the e

The W and Z boson production was measured via the muonic decay channel in proton-lead collisions at sNN=5.02 TeV at the Large Hadron Collider with the ALICE detector. The measurement covers backward (−4.46 < ycms < −2.96) and forward (2.03 < ycms < 3.53) rapidity regions, corresponding to Pb-going and p-going directions, respectively. The Z-boson production cross section, with dimuon invariant mas

Background: Infants exposed to maternal HIV infection who remain HIV-uninfected (HIV-exposed/uninfected; HIV-EU) may be at increased risk of growth retardation, which could be due both to directly HIV-related effects and to socio-economic factors overrepresented among HIV-positive women. Objective: To investigate growth development at 9-12 months of age in HIV-EU infants participating in preventio