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We have entered a monumental era in terms of realizing the impact of biodiversity loss on our everyday lives. We suffer from the consequences of biodiversity loss due to overexploitation of natural resources as we continue failing to restore biodiversity. One of the major consequences of biodiversity loss is the emergence of global pandemics. We are in urgent need of realizing the full potential o
Background: Proinflammatory mechanisms are implicated in pain states. Recent research indicates that patients with osteoarthritis (OA) with signs of central sensitization exhibit elevated cerebrospinal fluid (CSF) levels of interferon gamma-induced protein 10 (IP-10), Fms-related tyrosine kinase 1 (Flt-1), and monocyte chemoattractant protein 1 (MCP-1).Methods: The current prospective cohort study
Background and objectives: Neuroinflammation is implicated in the development and maintenance of persistent pain states, but there is limited data linking cerebrospinal fluid (CSF) inflammatory mediators with neurophysiological pain processes in humans. Study I aimed to investigate whether there are coherent changes in CSF inflammation associated with central sensitization (CS), and to evaluate po
Laryngeal papilloma (LP) is a rare benign disease, caused by recurrent multisite papillomas that are referred to as recurrent respiratory papillomatosis (RRP). RRP is caused primarily by two types of human papillomavirus (HPV): HPV6 and HPV11. The immune dysregulation within the microenvironment of the lesions has been shown to likely play a role in the development of RRP. The present study aimed
Objective: Cognitive workload monitoring (CWM) can enhance human-machine interaction by supporting task execution assistance considering the operators cognitive state. Therefore, we propose a machine learning design methodology and a data processing strategy to enable CWM on resource-constrained wearable devices. Methods: Our CWM solution is built upon edge computing on a simple wearable system, w
Opposition to immigration has featured prominently in the “cultural backlash” to globalization in Western nations and was a key determinant of Britain’s Brexit referendum. In this article, we draw on theories of intergroup threat to examine the effect of “right-wing authoritarianism” on immigration attitudes in the UK. Previous research suggests that cultural aspects of immigration are especially
This chapter visits some of the fundamental concepts from platform economics, network effects, and network externalities. Further on, it discusses definitions of two-sided and multi-sided markets, how they are treated as business models. These concepts are further compared to the concept service ecosystem. A case of a payment service provider whose business model contributes to the growth of e-com
Background: Septic arthritis (SA) is a serious condition in dogs that requires a prompt diagnosis and treatment to minimize long-term joint pathology. Although bacterial detection in synovial fluid (SF) through culture or cytology is often performed to confirm diagnosis, the sensitivity of these tests is low. The need for a reliable diagnostic tool to confirm the presence of bacteria in SF in huma
Sporadic Alzheimer's disease (sAD) is the most prevalent neurodegenerative disorder with no cure. Patients typically suffer from cognitive impairment imprinted by irreversible neocortex and hippocampal degeneration with overt synaptic and neuron dysfunction. Insulin-like growth factor 1 (IGF1) has proven to be a potent neuroprotective molecule in animal models of age-related neurodegeneration. In
Recreational fishing is a major tourism activity and is integral to the “Blue economy”. Despite having high rates of participation and it being an important economic activity, especially in coastal, lacustrine and riverine areas, there is relatively little research on its various tourism dimensions, including its role in branding and marketing. This paper provides an introductory context for the f
The bone tissue formed at the contact interface with metallic implants, particularly its 3D microstructure, plays a pivotal role for the structural integrity of implant fixation. X-ray tomography is the classical imaging technique used for accessing microstructural information from bone tissue. However, neutron tomography has shown promise for visualising the immediate bone-metal implant interface
Sweden has witnessed an increase in the rates of sexual crimes including rape. Knowledge of who the offenders of these crimes are is therefore of importance for prevention. We aimed to study characteristics of individuals convicted of rape, aggravated rape, attempted rape or attempted aggravated rape (abbreviated rape+), against a woman ≥18 years of age, in Sweden. By using information from the Sw
Restraints and seclusions are restrictive interventions used in psychiatric inpatient units when there is an imminent risk of harm to the patient or others. Coercive measures are controversial and can lead to negative consequences, including negative emotions, re-traumatization, injuries, or death. The article summarizes the last 10 years of literature regarding methods and strategies used for red
We develop the perspective of crystallization as a way to shed a light on the morphogenesis and stabilization of urban territories. We start by describing crystallization as a consolidation of a visible and singular order that establishes certain privileged directions of growth and breaks spatial and temporal symmetries. We then illuminate how crystallization processes unfold at different scales,
Importance: Homozygous variants in the neuronal ceroid lipofuscinosis type 5 (CLN5) gene are associated with neuronal ceroid lipofuscinosis, a progressive neurologic disorder that leads to ataxia, seizures, and early death. The association between a homozygous variant in this gene and a macular dystrophy is described here. Objective: To describe an autosomal recessive macular dystrophy associated
Aim/hypothesis: Environmental factors are believed to contribute to the risk of developing type 1 diabetes. The aim of this study was to investigate how size for gestational age affects the risk of developing childhood type 1 diabetes. Methods: Using the Swedish paediatric diabetes quality register and the Swedish medical birth register, children with type 1 diabetes diagnosed between 2000 and 201
