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Glucose effectiveness : Lessons from studies on insulin-independent glucose clearance in mice

Besides insulin-mediated transport of glucose into the cells, an important role is also played by the non-insulin-mediated transport. This latter process is called glucose effectiveness (acronym SG), which is estimated by modeling of glucose and insulin data after an intravenous glucose administration, and accounts for ≈70% of glucose disposal. This review summarizes studies on SG, mainly in human

Unusual mixed spin-state of Co3+ in the ground state of LaSrCoO4: Combined high-pressure and high-temperature study

The nature of the non-magnetic to paramagnetic transition of Co3+ oxide LaCoO3 was strongly disputed in the literature for many decades from a low-spin (LS) state below 20 K and to a mixed LS state and high-spin (HS) state or an intermediate-spin (IS) state above 100 K. In this context, the layered perovskite LaSrCoO4 is more favorable for a Jahn-Teller-active IS state because of an elongated dist

Mandibulotomy access to tumour sites : fewer complications for postoperative compared with preoperative radiotherapy

The purpose of this study was to compare complication rates at the mandibulotomy site between patients receiving preoperative radiotherapy (RT) and those receiving postoperative RT during treatment for oral and oropharyngeal cancer where the surgical procedure required a mandibular osteotomy to gain access to the tumour. Sixty-four consecutive patients treated during the period 2000–2015 were avai

Competing corporate sustainability perceptions in a global retail organization

Purpose: The purpose is to explore the different and often contradictory perceptions individual managers have about corporate sustainability within a global retailer. Design/methodology/approach: A qualitative case study method is used, including interviews and document studies. The authors study the global retailer IKEA. In total the authors have interviewed respondents on both the global level a

Endocrinology of thermoregulation in birds in a changing climate

The ability to maintain a (relatively) stable body temperature in a wide range of thermal environments by use of endogenous heat production is a unique feature of endotherms such as birds. Endothermy is acquired and regulated via various endocrine and molecular pathways, and ultimately allows wide aerial, aquatic, and terrestrial distribution in variable environments. However, due to our changing

Gradient waveform design for tensor-valued encoding in diffusion MRI

Diffusion encoding along multiple spatial directions per signal acquisition can be described in terms of a b-tensor. The benefit of tensor-valued diffusion encoding is that it unlocks the 'shape of the b-tensor' as a new encoding dimension. By modulating the b-tensor shape, we can control the sensitivity to microscopic diffusion anisotropy which can be used as a contrast mechanism; a feature that

Defining Fundamental Frequency for Almost Harmonic Signals

In this work, we consider the modeling of signals that are almost, but not quite, harmonic, i.e., composed of sinusoids whose frequencies are close to being integer multiples of a common frequency. Typically, in applications, such signals are treated as perfectly harmonic, allowing for the estimation of their fundamental frequency, despite the signals not actually being periodic. Herein, we provid

Framing Loss and Damage from climate change as the failure of Sustainable Development

Debates around “Loss and Damage” (L&D) from anthropogenic climate change have expanded rapidly since the adoption of the Warsaw International Mechanism (WIM) in 2013. Despite the urgent need for scientific best practice to inform policies to avoid, minimize and address L&D, the nascent research field faces internal disagreements and lacks a coherent conceptual framing, which hinder scienti