Purpose Phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutations are frequently observed in primary breast cancer. We evaluated their prognostic relevance by performing a pooled analysis of individual patient data. Patients and Methods Associations between PIK3CA status and clinicopathologic characteristics were tested by applying Cox regression models adjusted fo

Objectives: The aims of this study were to investigate the validity evidence for a novel procedure specific assessment tool of competence in endovascular aortic repair (EVAR) and to establish a pass/fail level for the assessment. Methods: Computed tomography angiography data of a 55 mm in diameter infrarenal aortic aneurysm was implemented into an endovascular simulator. Twenty-three physicians wi

Objectives: Antithymocyte globulin (ATG)-based immunosuppression remains a cornerstone in aplastic anaemia (AA) treatment. However, most ATG studies are not population-based and knowledge about real-world results concerning response and outcome could offer important information for treating physicians. Methods: We have recently performed a nationwide retrospective cohort study on all AA patients d

This thesis investigates the interaction between teaching and learning of English in young learners in Sweden and in Vietnam. It thus brings together two perspectives – teaching and learning – that are seldom compared between cultural contexts. The main focus of the study is to examine procedural and declarative knowledge of English grammar. A number of Grade 5 English lessons in primary school cl

Dysphonia is a program about impaired voice quality or hoarseness (i.e. dysphonia) mainly due to organic diseases of the larynx. The program aims to facilitate student oriented learning regarding the management of dysphonic patients. The targeted use is for training of undergraduate medical and speech pathology students, postgraduate residents under continuous medical education in the Ear,Nose, an

First results on the longitudinal asymmetry and its effect on the pseudorapidity distributions in Pb–Pb collisions at sNN = 2.76 TeV at the Large Hadron Collider are obtained with the ALICE detector. The longitudinal asymmetry arises because of an unequal number of participating nucleons from the two colliding nuclei, and is estimated for each event by measuring the energy in the forward neutron-Z

A measurement of the production of three isolated photons in proton–proton collisions at a centre-of-mass energy s=8 TeV is reported. The results are based on an integrated luminosity of 20.2 fb−1 collected with the ATLAS detector at the LHC. The differential cross sections are measured as functions of the transverse energy of each photon, the difference in azimuthal angle and in pseudorapidity be

The production of the charm-strange baryon Ξc 0 is measured for the first time at the LHC via its semileptonic decay into eΞ−+νe in pp collisions at s=7 TeV with the ALICE detector. The transverse momentum (pT) differential cross section multiplied by the branching ratio is presented in the interval 1

Pressure reducing valve plays an important role in thermodynamic systems. Under extreme operating conditions, greater demands are requested on pressure reducing systems. In this paper, a novel multi-stage high pressure reducing valve (MSHPRV) is proposed, which can achieve multi-stage pressure reducing processes, improve the flow characteristics and deal with complex conditions. Here, the effects

The multiphase micro-structured devices such as microchannels have been recently taken into consideration to replace the conventional equipment in different applications. The mass transfer coefficients and the interfacial area in the multiphase microchannels are much larger than those in the conventional equipment. This paper reviews the experimental studies on mass transfer in gas-liquid and liqu

Introduction: Anaerobic bacteria are believed to be common pathogens in severe infections. Yet, they are difficult to culture and consequently often unrecognised in clinical infections. Metronidazole is often used empirically for potential anaerobic infections, as the resistance to metronidazole is low. However, disadvantages of metronidazole use exist, including drug interactions, side effects an

Tourmalines from the late-Variscan Arbus pluton (SW Sardinia) and its metamorphic aureole were structurally and chemically characterized by single-crystal X-ray diffraction, electron and nuclear microprobe analysis, Mössbauer, infrared and optical absorption spectroscopy, to elucidate their origin and relationships with the magmatic evolution during the pluton cooling stages. The Arbus pluton repr

Serotonin [5-hydroxytryptamine (5-HT)] is associated with several chronic pulmonary diseases, recognizing 5-HT2 receptor antagonists as potential inhibitors of tissue remodeling. However, the effects of 5-HT2 receptors, especially 5-HT2B receptors on airway function and remodeling, are unclear. We investigated the role of 5-HT2B receptors on airway smooth muscle contractility and remodeling proces

Objectives: The aim was to investigate if there is an interaction between sitting time and leisure time physical activity on blood pressure and if there are age differences and sex differences in this respect. Methods: Linear regression analysis on cross-sectional data was performed in more than 45 000 men and women from two Swedish cohort studies, EpiHealth (45-75 years) and LifeGene (18-45 years

The production of a top quark in association with a Z boson is investigated. The proton–proton collision data collected by the ATLAS experiment at the LHC in 2015 and 2016 at a centre-of-mass energy of s=13TeV are used, corresponding to an integrated luminosity of 36.1fb−1. Events containing three identified leptons (electrons and/or muons) and two jets, one of which is identified as a b-quark jet

Experimental evidence for Majorana bound states (MBSs) is so far mainly based on the robustness of a zero-bias conductance peak. However, similar features can also arise due to Andreev bound states (ABSs) localized at the end of an island. We show that these two scenarios can be distinguished by an interferometry experiment based on embedding a Coulomb-blockaded island into an Aharonov-Bohm ring.

Purpose: In this paper, we discuss the role of participatory research in integrated agricultural technology development using the example of a solar fruit drying project in Mozambique. Design/methodology/approach: We engage in seven participatory exercises with groups of farmers from two farmers’ associations in Inharrime district in Mozambique to identify their needs for solar fruit drying that a