The role of mutations have been subject to many controversies since the formation of the Modern Synthesis of evolution in the early 1940ties. Geneticists in the early half of the twentieth century tended to view mutations as a limiting factor in evolutionary change. In contrast, natural selection was largely viewed as a “sieve” whose main role was to sort out the unfit but which could not create a

Neural network training and validation rely on the availability of large high-quality datasets. However, in many cases only incomplete datasets are available, particularly in health care applications, where each patient typically undergoes different clinical procedures or can drop out of a study. Since the data to train the neural networks need to be complete, most studies discard the incomplete d

Due to the migration megatrend, efficient and effective second-language acquisition is vital. One proposed solution involves AI-enabled conversational agents for person-centered interactive language practice. We present results from ongoing action research targeting quality assurance of proprietary generative dialog models trained for virtual job interviews. The action team elicited a set of 38 re

Background: Food access is an important aspect of health promotion for the elderly. The aim of this study was to investigate the relationship between distance to the nearest food store and diet variety in rural community-dwelling elderly Japanese. Methods: This cross-sectional study analyzed data from 1,103 elderly participants surveyed by mail in rural areas of Japan. Diversity of food intake was

Aims/hypothesis: Diabetic kidney disease (DKD) is the leading cause of kidney failure and has a substantial genetic component. Our aim was to identify novel genetic factors and genes contributing to DKD by performing meta-analysis of previous genome-wide association studies (GWAS) on DKD and by integrating the results with renal transcriptomics datasets. Methods: We performed GWAS meta-analyses us

BACKGROUND Ibrutinib, a Bruton's tyrosine kinase inhibitor, may have clinical benefit when administered in combination with bendamustine and rituximab and followed by rituximab maintenance therapy in older patients with untreated mantle-cell lymphoma. METHODS We randomly assigned patients 65 years of age or older to receive ibrutinib (560 mg, administered orally once daily until disease progressio

Verksamhet, människa och omvärld är den första boken på svenska om den kulturhistoriska verksamhetsteorin för de som arbetar med människor i social utsatthet. Centralt i teorin är att koppla ihop människan och hennes omvärld med begreppet verksamhet. Därigenom framkommer nya teoretiska perspektiv samt en helhetssyn på sociala problem som våld, gäng, sexuella övergrepp, missbruk, kriminalitet, mobb

We present the direct stabilization of the CEP of a high-repetition rate OPCPA by employing a Stereo-ATI pulsemeter for single-shot detection and feedback to the oscillator at the full OPCPA repetition rate.

Two-dimensional (2D) perovskites have emerged as promising building blocks for optoelectronic applications. To fabricate high-performance devices, the relation between the material structures and their function in terms of excited state and charge carrier dynamics need to be well understood. In this thesis, we investigate photophysics of 2D lead halide perovskite with different compositions to rev

The race to publish results during the outbreak of the new coronavirus (SARS-CoV-2) has highlighted the relevance of sharing data and research results more quickly and openly than the current scientific communication system, as well as the role of social media in this context. This paper aims to analyze the impact of open access on the production and dissemination of knowledge about COVID-19 in tr

Futures studies have shown an accelerated growth since the post-World War II period, in which governments and private companies have been attentive to the importance of "forecasting" new trends, mainly technological ones, for their security as an institution. Such studies have gained a new panorama from the proliferation of data on massive scales and the increasing processing capacity, leading to

Spectral broadening via the multi-pass cell technique provides a power-efficient route to direct post-compression of high-power diode-pumped Yb lasers. The talk provides an overview of the method, its performances and discuss prospective advances and applications.

The nucleus 212Po has been produced through the fragmentation of a 238U primary beam at 1 GeV/nucleon at GSI, separated with the FRagment Separator, FRS, and studied via isomer γ-decay spectroscopy with the RISING setup. Two delayed previously unknown γ rays have been observed. One has been attributed to the E3 decay of a 21− isomeric state feeding the α-emitting 45-s (18+) high-spin isomer. The o

Up to tenfold power enhancement of waveform-stable few-cycle pulses is demonstrated in a minimally-dispersive resonator (22-37 THz). This enables spectroscopy of molecular samples based on impulsive excitation and electro-optic sampling at 66 m interaction length.

We demonstrate self-compression of 173 fs pulses centered at 1030 nm down to 19.5 fs through electro-optic phase modulation by the phonon-polariton waves generated in a phase-matched intra-pulse difference-frequency mixing.

Two-dimensional terahertz strong-field spectroscopy reveals wave-mixing processes up to eighth order in a free-running quantum cascade laser, unravelling its sub-cycle gain dynamics and nonlinearities in a regime of negative absorption.

We discuss basic pulse energy scaling principles for multi-pass cells (MPCs) and introduce a novel multi-pass cell type which we employ to numerically predictpost-compression of 125 mJ pulses using a 2 m setup.