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Low plasma concentrations of apolipoprotein M are associated with disease activity and endothelial dysfunction in systemic lupus erythematosus

Background: Apolipoprotein M (apoM) is a 25-kDa apolipoprotein present in 5% of high-density lipoprotein (HDL) particles. It is suggested to be anti-atherogenic and to play a key role in sustaining endothelial barrier integrity. SLE patients have increased cardiovascular disease risk, and we aimed to investigate if apoM levels reflect endothelial function in SLE. Since apoM plasma levels decrease

Characterization of the NEP of mid-infrared upconversion detectors

We present a scheme to estimate the noise equivalent power (NEP) of the frequency upconversion detectors (UCDs), detecting mid-infrared (MIR) light. The NEP of the UCD is a combined contribution of NEPs from the upconversion process and from the photodetector, used for detecting the upconverted signal. The 2-5- μm MIR range is particularly investigated in this letter using a bulk periodically pole

Interaction of Laponite with Membrane Components - Consequences for Bacterial Aggregation and Infection Confinement

The antimicrobial effects of Laponite nanoparticles with or without loading of the antimicrobial peptide LL-37 was investigated along with their membrane interactions. The study combines data from ellipsometry, circular dichroism, fluorescence spectroscopy, particle size/ζ potential measurements, and confocal microscopy. As a result of the net negative charge of Laponite, loading of net positively

SIPA1L3 methylation modifies the benefit of smoking cessation on lung adenocarcinoma survival : an epigenomic–smoking interaction analysis

Smoking cessation prolongs survival and decreases mortality of patients with non-small-cell lung cancer (NSCLC). In addition, epigenetic alterations of some genes are associated with survival. However, potential interactions between smoking cessation and epigenetics have not been assessed. Here, we conducted an epigenome-wide interaction analysis between DNA methylation and smoking cessation on N

From Uniforms to Monitors : Persuasive design and targeting in international law

US counterinsurgency, thanks to geographically unbounded reach of drones, is characterized by extending wartime violence from battlefield to the monitor. In this article, we claim that the significance of the ‘new technologies’ of looking and targeting lies in their capacity to negotiate laws of war into the material world, thus determining the legitimacy of their expansive violence. Such negotiat

A taxonomy for improving industry-academia communication in IoT vulnerability management

Background: In software engineering, industry-academia is a symbiotic relationship. Researchers need to be aware of the industry to produce relevant research, while practitioners are educated in academia and could take advantage of empirical research. The SERP taxonomy architecture is designed to support communication between practitioners and researchers in software engineering. Objective: The pu