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Non-invasive fibrosis scoring systems can predict future metabolic complications and overall mortality in non-alcoholic fatty liver disease (NAFLD)

BACKGROUND AND AIM: Progression to fibrosis in non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of liver-related events, overall mortality and possibly metabolic comorbidities. Our aim was to determine if non-invasive fibrosis scoring systems can predict the future risk of diabetes mellitus, cardiovascular disease (CVD), chronic kidney disease (CKD), liver-related eve

Insulin resistance with impaired fasting glucose increases the risk of NAFLD

Background: Our aim was to investigate the frequency of elevated liver enzymes and NAFLD in patients with known insulin resistance during 15 years of follow-up. Methods: Subjects with insulin resistance were identified from a population-based prospective cohort study in Sweden, Malm? Diet and Cancer Study, conducted in 1991-1996. Inall, 285 non-diabetic subjects with insulin resistance established

A Computer Algorithm for Determining Local Activation Times in Electrograms Obtained during Atrial Fibrillation

A critical factor in analyzing the propagation of activation waves in the myocardium is the definition of local activation times (LAT) in the electrogram. The authors have formulated and tested a definition of LAT in bipolar electrograms applicable to atrial electrograms containing deflections with wide variation in complexity, e.g. those obtained during rapid, irregular atrial rhythm, i.e. atrial

Nonlinear Beam Physics

A condensed treatment of conventional beam physics (both linear and nonlinear) is given for the non-expert; this constitutes a minimum knowhow for constructing simulations of rudimentary beamlines. The criteria for an ideal nonlinear charged-particle simulation algorithm are then presented, leading to the derivation of a symplectic, explicit, Lorentz-covariant integrator.Space charge (inter-particA condensed treatment of conventional beam physics (both linear and nonlinear) is given for the non-expert; this constitutes a minimum knowhow for constructing simulations of rudimentary beamlines. The criteria for an ideal nonlinear charged-particle simulation algorithm are then presented, leading to the derivation of a symplectic, explicit, Lorentz-covariant integrator.Space charge (inter-partic

Epicardial Right Free Wall Mapping in Chronic Atrial Fibrillation—Documentation of Repetitive Activation with a Focal Spread—A Hitherto Unrecognized Phenomenon in Man

BACKGROUND: Previous studies have shown that atrial fibrillation of recent onset in man is based on a varying number of simultaneously present activation waves reentering either themselves or each other. In the present study, right atrial activation during chronic atrial fibrillation in man was studied. METHODS AND RESULTS: In 16 patients with chronic atrial fibrillation multiple epicardial record

Swedish and Scottish National Transport Policy and Spend: A Social Equity Analysis

The topic of social equity in transport planning has been dealt with, in particular, by authorssuch as Martens (2012) and Martens and Golob (2012) using a social justice based-approach. However,such an approach, whilst valuable and analytically rigorous (based as it is on accessibility modelling),does not consider a wide range of possible other social impacts of transport, as set out in a framewor

Effect of delayed cord clamping of term babies on neurodevelopment at 12 months : A randomized controlled trial

Background: Delayed cord clamping (DCC) is associated with an improved iron status at 8 months, a reduction of anemia at 12 months, and an improved development at 4 years. Assessment of the development after DCC has not been performed earlier in a setting with a high prevalence of iron deficiency. Objective: The aim of this paper was to investigate the effects of DCC compared to early cord clampin

Reference intervals for reticulocyte hemoglobin content in healthy infants

Objectives: Iron deficiency anemia in childhood is a serious public health problem worldwide. Reticulocyte hemoglobin content (Ret-He) is a novel biomarker of iron deficiency adopted for adults but there is a lack of reference intervals for Ret-He in infants. The aim of this study was to provide data from healthy infants. Methods: Swedish infants (n = 456), born at term after normal pregnancies we

Factors associated with timing of umbilical cord clamping in tertiary hospital of Nepal

OBJECTIVE: Delayed umbilical cord clamping (DCC) (≥ 60 s) is recognized to improve iron status and neurodevelopment compared to early umbilical cord clamping. The aim of this study is to identify current umbilical cord clamping practice and factors determining the timing of clamping in a low-resource setting where prevalence of anemia in infants is high.RESULTS: A cross-sectional study design incl

Wait a minute? : An observational cohort study comparing iron stores in healthy Swedish infants at 4 months of age after 10-, 60- and 180-second umbilical cord clamping

BACKGROUND AND OBJECTIVE: Umbilical cord blood (UCB) is a valuable stem cell source used for transplantation. Immediate umbilical cord (UC) clamping is widely practised, but delayed UC clamping is increasingly advocated to reduce possible infant anaemia. The aim of this study was to investigate an intermediate UC clamping time point and to evaluate iron status at the age of 4 months in infants who

Effect of delayed versus early umbilical cord clamping on neonatal outcomes and iron status at 4 months : A randomised controlled trial

Objective: To investigate the effects of delayed umbilical cord clamping, compared with early clamping, on infant iron status at 4 months of age in a European setting. Design: Randomised controlled trial. Setting: Swedish county hospital. Participants: 400 full term infants born after a low risk pregnancy. Intervention: Infants were randomised to delayed umbilical cord clamping (≥180 seconds after