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Quality of life may be affected more by disease parameters and response to therapy than by haemoglobin changes

Earlier studies showing a negative impact of anaemia on quality of life (QOL) lack adequate adjustment for confounding factors such as disease stage and tumour response. We examined the impact of haemoglobin concentration on QOL scores of 745 multiple myeloma patients followed from diagnosis, adjusting for objective disease parameters. Data from two Nordic studies with the EORTC QLQ-C30 questionna

Mechanisms of molecular response in the optimal control of photoisomerization

We report on adaptive feedback control of photoinduced barrierless isomerization of 1,1'-diethyl-2,2'-cyanine in solution. We compare the effect of different fitness parameters and show that optimal control of the absolute yield of isomerization (photoisomer concentration versus excitation photons) can be achieved, while the relative isomerization yield (photoisomer concentration versus number of

Photodynamic therapy vs. cryosurgery of basal cell carcinomas: results of a phase III clinical trial

Background A previously reported randomized clinical trial showed treatment of Bowen's disease using photodynamic therapy (PDT) with topically applied delta -aminolaevulinic acid (ALA) to be at least as effective as cryosurgery and to be associated with fewer adverse effects. Objectives To compare ALA-PDT and cryotherapy in the treatment of histopathologically verified basal cell carcinomas (BCCs)

Body condition of shorebirds upon arrival at their Siberian breeding grounds

Arctic breeding shorebirds carry substantial body stores on their long-distance migrations from their non-breeding grounds. Upon arrival at the breeding area the remains of these stores can be used for egg formation, insurance against poor feeding conditions or rebuilding organs. We quantified body condition (body mass, total body water, lean body mass and fat mass estimated using the deuterium di

Reliable geographical multicast routing in vehicular ad-hoc networks

Vehicular ad-hoc networks (VANETs) offer a large number of new potential applications without relying on significant infrastructure. Many of these applications benefit from multi-hop relaying of information, thus requiring a routing protocol. Characteristics unique to VANETs (such as high mobility and the need for geographical addressing) make many conventional ad hoc routing protocols unsuitable.

Macroscopic modelling of coupled multiphysics in swelling cellulose based materials

Paperboard has been the basis for packaging materials used to aseptically store and protect food and beverages for a long time. To ensure that there are no bacteria that can spoil the product, sterilizing treatments are made. One such treatment is the retorting process, which involves heating to high temperatures in a pressurized environment of water vapor and dry air. The porous nature of paper m

Temporally Dense Ray Tracing

We present a technique for real-time ray tracing with the goal of reaching 240 frames per second or more. The core idea is to trade spatial resolution for faster temporal updates in such a way that the display and human visual system aid in integrating high-quality images. We use a combination of frameless and interleaved rendering concepts together with ideas from temporal antialiasing algorithmsWe present a technique for real-time ray tracing with the goal of reaching 240 frames per second or more. The core idea is to trade spatial resolution for faster temporal updates in such a way that the display and human visual system aid in integrating high-quality images. We use a combination of frameless and interleaved rendering concepts together with ideas from temporal antialiasing algorithms

EDGE: from quiescent to gas-rich to star-forming low-mass dwarf galaxies

We study how star formation is regulated in low-mass field dwarf galaxies (⁠105≤M⋆≤106M⊙⁠), using cosmological high-resolution (⁠3pc⁠) hydrodynamical simulations. Cosmic reionization quenches star formation in all our simulated dwarfs, but three galaxies with final dynamical masses of 3×109M⊙ are subsequently able to replenish their interstellar medium by slowly accreting gas. Two of these galaxie

Arkitektur och monument i maktens tjänst

Recension av Sofia Aittomaa, Fyra kejserliga monument i Finland. Tillkomst, mottagande och bemötande, Håkan Hökerberg (ed.), Architecture as propaganda in twentieth-century totalitarian regimes. History and heritage och Pernilla Ståhl, Triumfbågen i Mogadishu. Om det kolonialt byggda.

Developmental Citizenship, Symbolic Landscapes, and Transformation in China and South Korea

Despite glaring differences between South Korean and Chinese societies, South Korea offers an instructive reference point when thinking about developmental citizenship in China. Experiences of mobilization, albeit distinct in each country, inform the sorts of symbols that bring people together for resistance against or compliance with authority. The concept of developmental citizenship, besides dr

Authoritarian Legality after Authoritarianism : Legal Governance of Parties and Elections before and after Democratic Transition in South Korea

The Republic of Korea (ROK) was designed as a Cold War democracy. It started as an electoral regime with formal commitments to democratic values, but institutions designed to keep the state secure also imposed limits on domestic political struggle. From the ROK’s founding in 1948 to the political liberalization of 1987, the political system shifted between orders that might be labeled more democra

More than Anti-communism : Electoral Politics and the Meanings of Democracy in Taiwan

Governments across anti-communist Asia, with US backing or tacit consent, devised institutions and practices for marginalising popular forces. Such internalisation of the Cold War involved measures ranging from violence and ideological mobilisation to disciplinary modes of control. With democratisation, Cold War devices for domestic control could remain entrenched or be rolled back. Examining the

Surface-modified nanoerythrosomes for potential optical imaging diagnostics

Nanoerythrosomes (NERs), vesicle-like nanoparticles derived from red blood cells, represent a new and interesting vector for therapeutic molecules and imaging probes, mainly thanks to their high stability and excellent biocompatibility. Aiming to present a proof-of-concept of the use of NERs as diagnostic tools for in vitro/in vivo imaging purposes, we report here several functionalization routes

The coordinated outcome of STIM1-Orai1 and superoxide signalling is crucial for headkidney macrophage apoptosis and clearance of Mycobacterium fortuitum

The mechanisms underlying M. fortuitum-induced pathogenesis remains elusive. Using headkidney macrophages (HKM) from Clarias gariepinus, we report that TLR-2-mediated internalization of M. fortuitum is imperative to the induction of pathogenic effects. Inhibiting TLR-2 signalling alleviated HKM apoptosis, thereby favouring bacterial survival. Additionally, TLR-2-mediated cytosolic calcium (Ca2+)c

Circular business model experimentation : Demystifying assumptions

Circular business model experiments may help firms transition towards a circular economy. Little is known about how the participants of experimentation – entrepreneurs, intrapreneurs, innovation managers – develop and test their assumptions during the experimentation process to achieve more circular outcomes. Using a design-science approach, we investigate this process and develop principles to im