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Background: Aortic valve stenosis (AVS) and coronary artery disease (CAD) have a significant genetic contribution and commonly co-exist. To compare and contrast genetic determinants of the two diseases, we investigated associations of the LPA and 9p21 loci, i.e. the two strongest CAD risk loci, with risk of AVS. Methods: We genotyped the CAD-associated variants at the LPA (rs10455872) and 9p21 loc

The ongoing emission of greenhouse gases (GHGs) is triggering changes in many climate hazards that can impact humanity. We found traceable evidence for 467 pathways by which human health, water, food, economy, infrastructure and security have been recently impacted by climate hazards such as warming, heatwaves, precipitation, drought, floods, fires, storms, sea-level rise and changes in natural la

En hemgjord ask av näver -- vad behöver man? Ett stycke ny samhällsvetenskaplig kunskap -- vad behöver man? Den här texten är ett föredrag om akademiskt hantverk och dess material, verktyg, åskådliggörande, ändamål och estetik.

The aperiodic nature of geomagnetic field variations, both in intensity and direction, can aid in dating archaeological artefacts, volcanic rocks, and sediment records that carry a palaeomagnetic signal. The success of palaeomagnetic dating relies upon our knowledge of past field variations at specific locations. Regional archaeo- and palaeomagnetic reference curves and predictions from global geo

Background: Deiodinase type 2 (DIO2) is an enzyme that catalyzes the production of the active form of thyroid -hormone triiodothyronine (T3) from thyroxine (T4) and is important for maintaining intracellular T3 levels. Single nucleotide polymorphisms (SNPs) in DIO2 were associated with several diseases. The association of SNPs in DIO2 with Graves' disease (GD) was suggested in 2 Russian studies. O

We prove in this article that the set of semi-hyperbolic rational maps has Lebesgue measure zero in the space of rational maps on the Riemann sphere for a fixed degree d = 2. This extends the earlier result [3] to its full generality.

Research on recruitment shows that networks matter and are effective as search channels. The aim of this article is to analyse how recruitment practices varies over time, and specifically, how it has varied before, during, and after the Great Recession 2008–2009. The findings are that recruitment practices change both in the short term, in relation to labour supply, which we can call a cyclical ef

Background. Regular exercise reduces pulse rate, but it is less clear how prolonged sitting time affects pulse rate. Our hypothesis was that high physical activity could compensate for prolonged sitting time regarding the pulse rate. Methods. Regression analysis was performed on cross-sectional data including 47,457 men and women based on two Swedish cohort studies, EpiHealth (18–45 years) and Lif

In this work, we study the clutter and multi-path propagation in a time-domain millimeter-wave reflectometry setup, used for material characterization or short-range imaging. The signal energy and fidelity factor of the different reflection components is analyzed in dependence of the distance from the target. Due to the change in pulse distortion in the multi-path components, the system impulse re

AIMS: The aim of this study was to determine the incidence of valve-related complications in patients with a mechanical aortic valve prosthesis and to identify risk factors for an adverse outcome.METHODS AND RESULTS: In the 424 patients, event-free survival rates 5 and 10 years after aortic valve replacement were 62% and 37%, respectively. The linearized incidence of thromboembolic events was 4.4%