Background and purpose: Statin treatment may ameliorate viral infection-induced exacerbations of chronic obstructive pulmonary disease (COPD), which exhibit Th2-type bronchial inflammation. Thymic stromal lymphopoietin (TSLP), a hub cytokine switching on Th2-inflammation, is overproduced in viral and dsRNA-stimulated bronchial epithelial cells from COPD donors. Hence, TSLP may be causally involve

Alpha 1-antichymotrypsin (ACT) inhibits chymotrypsin-like enzymes, particularly neutrophil cathepsin G. Moreover, ACT in its native form suppresses chemotaxis of neutrophils and decreases neutrophil production of superoxide radicals. We recently showed that Moraxella catarrhalis ubiquitous surface protein (Usp) A1 is able to specifically bind ACT in the context of a novel virulence mechanism. In t

The analysis of the importance of different types of regional innovation systems must take place within a context of the actual knowledge base of various industries in the economy, as the innovation processes of firms are strongly shaped by their specific knowledge base. In this paper, we shall distinguish between two types of knowledge base: analytical and synthetic. These types indicate differen

Summary Childhood cancer survivors (CCS) have an increased risk of impaired spermatogenesis, but data regarding the disease- and treatment-related risk factors of azoospermia are scarce. Such information is crucial both for counselling CCS and for selecting patients for testicular tissue cryopreservation. The proportion of azoospermic men in CCS was 18% [95% confidence interval (CI): 12-26], speci

Popular Abstract in French Un Etat-providence se compose d’une variété d’organisations clientes dans lequel, parmi d’autres professions, les universitaires et les travailleurs sociaux sont actifs. Le travail social comme une profession s’est développé dans un contexte de bien-être où les changements à différents niveaux de l’individu, de l’organisation et la société pose de nouveaux défis pour la A welfare state consists of a variety of client organisations withinwhich, among other professions, academics and social workers areactive. Social work as a profession has developed in a welfare contextwhere changes at the different levels of the individual, organisationand society constantly pose new challenges to the profession.When a society undergoes a total transformation, this also affectshi

“Collaboration” is generally portrayed as being beneficial to authorities, even if previous collaborative research shows that conflicts are common between authorities who are supposed to cooperate. What takes place when different actors in the collaboration meet in practice? And what is the best way to analyse this? In qualitative studies, it is often problematic to go from an exhaustive analysis

Objective: The longitudinal epidemiological development of the new variant of Chlamydia trachomatis was studied after appropriate testing procedures had been introduced when the strain was detected in 2006. Methods: The number of cases of the new variant of C trachomatis was followed from 2007 through 2011 from the laboratory records. Testing for C trachomatis is centralised to one laboratory wit

Two novel sites of autophosphorylation were localized to the C-terminal tail of the PDGF beta-receptor. To evaluate the importance of these phosphorylation sites, receptor mutants in which Tyr1009, Tyr1021 or both were replaced with phenylalanine residues, were expressed in porcine aortic endothelial (PAE) cells. These mutants were similar to the wild type receptor with regard to protein tyrosine

Förhärskande tolkningstraditioner betraktar sofisten Protagoras som företrädare för en antropocentrisk humanism, som gör allt relativt till en värdeskapande och meningsgivande mänsklighet eller mänsklig individ, och därmed en centralgestalt (vid sidan av Sokrates) i den grekiska vändningen från natur till kultur under 400-talet f.Kr. Det är dessa betydelser som brukar ges hans välkända maxim: ”MänIn opposition to the traditional interpretation of Protagoras's Homo Mensura-Satz ("Man is the measure of all things") as a founding tenet of Western humanism, this essay challenges the notion of an inherent anthropocentrism of the dictum (that all things are relative to man as species or individual). In a reading of the most important sources of antiquity, namely Plato, Aristotle and Sextus Empir

AIM: The long-term effects of reconstructions of the gastrointestinal tract after gastrectomy on plasma levels of gastrointestinal hormones that contribute to food intake controls were evaluated. MATERIALS AND METHODS: Domestic pigs were randomly assigned to sham-surgery or total gastrectomy followed by reconstruction with oesophagojejunostomy on a Roux-en-Y loop (OJRY), jejunal interposition betw

Filosofisk Tidskrift 1/01