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Prior treatment exposure in patients with relapsed/refractory multiple myeloma may affect outcomes with subsequent therapies. We analyzed efficacy and safety according to prior treatment in the phase 3 TOURMALINE-MM1 study of ixazomib-lenalidomide-dexamethasone (ixazomib-Rd) versus placebo-Rd. Patients with relapsed/refractory multiple myeloma received ixazomib-Rd or placebo-Rd. Efficacy and safet
Background: Outcome- or competency-based education is well established in medical and health sciences education. Curricula are based on courses where students develop their competences and assessment is also usually course-based. Clinical reasoning is an important competence, and the aim of this study was to monitor and describe students' progression in professional clinical reasoning skills durin
We address the problem of playing turn-based multi-action adversarial games, which include many strategy games with extremely high branching factors as players take multiple actions each turn. This leads to the breakdown of standard tree search methods, including Monte Carlo Tree Search (MCTS), as they become unable to reach a sufficient depth in the game tree. In this paper we introduce Online Ev
Chronic myelomonocytic leukemia (CMML) is a myeloproliferative and myelodysplastic neoplasm with few treatment options and dismal prognosis. The role of natural killer (NK) cells and other antileukemic lymphocytes in CMML is largely unknown. We aimed to provide insight into the mechanisms of immune evasion in CMML with a focus on immunosuppressive reactive oxygen species (ROS) formed by the myeloi
Nanostructured and microstructured thin foils have been fabricated and used experimentally as targets to manipulate the spatial profile of proton bunches accelerated through the interaction with high intensity laser pulses (6×1019 W/cm2). Monolayers of polystyrene nanospheres were placed on the rear surfaces of thin plastic targets to improve the spatial homogeneity of the accelerated proton beams
It is well-known that dyadic martingale transforms are a good model for Calderón–Zygmund singular integral operators. In this paper we extend some results on weighted norm inequalities to vector-valued functions. We prove that if W is an A2 matrix weight, then the weighted L2-norm of a Calderón–Zygmund operator with cancellation has the same dependence on the A2 characteristic of W as the weighted
Norway spruce (Picea abies) is one of the dominant tree species in the European boreal zone with the capacity to grow over large areas within Europe. It is an important emitter of biogenic volatile organic compounds (BVOCs), which can act as precursors of photochemical smog and ozone and contribute to the formation and growth of secondary organic aerosols (SOA) in the atmosphere.Isoprenoid emissio
Sweden was historically, and remains, a high-migration country. The chapter considers its experience using the census and population register data that are available for the analysis of migration over long historical periods, assessing their strengths and weaknesses. It then outlines levels of inter-parish moves from 1900 to 2015 as well as moves over shorter distances from the 1970s. The former o
Characteristic modes (CMs) of a spherical shell are found analytically as spherical harmonics normalized to radiate unitary power and to fulfill specific boundary conditions. The presented closed-form formulas lead to a proposal of precise synthetic benchmarks that can be utilized to validate the method-of-moments matrix or performance of CM decomposition. Dependence on the mesh size, electrical s
We propose to constrain the gluon Wigner distribution in the nucleon by studying the exclusive diffractive dijet production process in ultraperipheral proton-nucleus collisions (UPCs) at the RHIC and the LHC. Compared to the previous proposal in Ref. [Y. Hatta, B. W. Xiao, and F. Yuan, Phys. Rev. Lett. 116, 202301 (2016).PRLTAO0031-900710.1103/PhysRevLett.116.202301] to study the same observable i
In this work, 22 sets of cutting data and tool life for longitudinal turning of steel are analyzed using the Colding equation. When modeling tool life with a limited number of tool performance data points, the model error may be low for these points. Evaluating the model for test points not used when computing the model coefficients may give larger errors for these points. This work proves that th
cBN cutting tools with superior mechanical properties are widely used in machining various hard materials. The microgeometry of cBN cutting tools, such as the edge radius, has great influence on the surface quality of components and tool life. For optimized tool geometry, it is crucial to understand the influence of the cBN cutting tool microgeometry on the machined surface quality. In this study,
Samtal mellan Anders Mortensen och Daniel Möller en eftermiddag i slutet av augusti 2017, vid en mikrofon på Språk- och litteraturcentrums café i Lund, med utgångspunkt i Gunnar Ekelöf, Dikter i Grönköpings Veckoblad. Utgivna med en inledning och kommentarer av Daniel Möller (2016) och de nya rön som Möller nu framlägger i Rethinking Scandinavia
Introduction of new myeloma therapies offers new options for patients refractory to immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs). In this multicenter study, patients with relapsed multiple myeloma, who have received at least three prior lines of therapy, are refractory to both an IMiD (lenalidomide or pomalidomide) and a PI (bortezomib or carfilzomib), and have been exposed to an
Catharina Stenqvist (1950–2014) verkade som religionsfilosof med intresse för frågor om religiös erfarenhet och människans existentiella villkor. Hennes forskning kretsade kring mystik och mening och hon argumenterade för vikten att tala om livshållning snarare än livsåskådning. I föreliggande essä läser Patrik Fridlund en kort och lite annorlunda text av henne. I sitt efterord till denna essä skr
