Land-cover changes have a clear impact on local climates via biophysical effects. European land cover has been affected by human activities for at least 6000 years, but possibly longer. It is thus highly probable that humans altered climate before the industrial revolution (AD1750–1850). In this study, climate and vegetation 6000 years (6 ka) ago is investigated using one global climate model, two

We present the archaeological discovery and microscale X-ray Computed Tomography (µCT) scanning of a silver coin purse lost in a medieval shipwreck while the king who issued many of the coins was aboard. The find demonstrates that shipwrecks are extraordinary repositories of historical information, in this case providing insight into one of the most important and dramatic events of medieval Scandi

Efter flera krig övergick på 1600-talet Skåne, Halland och Blekinge från Danmark till Sverige, medan Bornholm förblev danskt. Övergången var gradvis, inte utan motstånd, och den varierade mellan och även inom landskapen. Artikeln undersöker hur dansk och svensk överhöghet synliggjordes i kyrkorna under denna övergångstid med bilder på riksvapnet, kungliga namn och monogram, särskilt på altaruppsat

The Internet of Things (IoT) paradigm, has opened up the possibility of using the ubiquity of small devices to route information without the necessity of being connected to a Wide Area Network (WAN). Use cases of IoT devices sending updates that are routed and delivered by other IoT devices have been proposed in the literature. In this paper we focus on receivers only interested in the freshest up

I describe changes in the social structure of the Swedish workforce over the long term. Occupational coding from nine full count censuses from 1880 until 1990 and 2001-2016 occupational registers is aligned to comprehensively map social stratification for birth cohorts born 1820-1985. We show occupational upgrading for working women and men over the past 150 years. The male andfemale workforce con

Conventional social mobility research misses substantial inequalities of opportunity. To capture intergenerational persistence of family social status we need to move beyond parent-child associations in occupation or income. Models that incorporate surname group belonging show that families do not regress to a population mean at the speed implied by parent-child associations. Their mobility is fur

How does parental social status affects child status attainment across time? Social mobility studies have traditionally studied parent-child associations using one ‘dominant’ parent to reflect social origin. However, the institutions of family and work have changed substantially over the past 150 years, in Sweden as elsewhere. These changes are associated with changes in intergenerationalstatus mo

Resources have always been at the heart of civil society theorizing. While many earlier theories have focused on resources in the forms of money, people, ideas, or personnel, recent debates highlight the Internet and social media as new environments for resource mobilization. This chapter contributes to current research by comparing the human, economic, and political resources accumulated both offResources have always been at the heart of civil society theorizing. While many earlier theories have focused on resources in the forms of money, people, ideas, or personnel, recent debates highlight the Internet and social media as new environments for resource mobilization. This chapter contributes to current research by comparing the human, economic, and political resources accumulated both off

OBJECTIVES: Patient-reported outcome measures (PROMs) are important for clinical practice and research. Given the high unmet need, our aim was to develop a comprehensive PROM for systemic sclerosis (SSc), jointly with patient experts. METHODS: This European Alliance of Associations for Rheumatology (EULAR)-endorsed project involved 11 European SSc centres. Relevant health dimensions were chosen an

Neural mechanisms behind stereopsis, which requires simultaneous disparity inputs from two eyes, have remained mysterious. Here we show how ultrafast mirror-symmetric photomechanical contractions in the frontal forward-facing left and right eye photoreceptors give Drosophila superresolution three-dimensional (3D) vision. By interlinking multiscale in vivo assays with multiscale simulations, we rev

Background: Alzheimer’s disease is a progressive, irreversible, and fatal disease for which accumulation of amyloid beta is thought to play a key role in pathogenesis. Aducanumab is a human monoclonal antibody directed against aggregated soluble and insoluble forms of amyloid beta. Objectives: We evaluated the efficacy and safety of aducanumab in early Alzheimer’s disease. Design: EMERGE and ENGAG

BackgroundHealthcare system and intersectoral public health policies play a crucial role in improving population health and reducing health inequalities. This study aimed to quantify their impact, operationalized as avoidable deaths, on the gap in life expectancy (LE) and lifespan inequality (LI) between Iran and three neighbour countries viz., Turkey, Qatar, and Kuwait in 2015–2016.MethodsAnnual

The draft Post-2020 Global Biodiversity Framework commits to achievement of equity and justice outcomes and represents a “relational turn” in how we understand inclusive conservation. Although “inclusivity” is drawn on as a means to engage diverse stakeholders, widening the framing of inclusivity can create new tensions with regard to how to manage protected areas. We first offer a set of tensions

Objectives: To compare the outcomes of patients with postcardiotomy shock treated with venoarterial extracorporeal membrane oxygenation (VA-ECMO) only compared with VA-ECMO and intra-aortic balloon pump (IABP). Design: A retrospective multicenter registry study. Setting: At 19 cardiac surgery units. Participants: A total of 615 adult patients who required VA-ECMO from 2010 to 2018. The patients we

Coherent nonlinear spectroscopies and imaging in the X-ray domain provide direct insight into the coupled motions of electrons and nuclei with resolution on the electronic length scale and timescale. The experimental realization of such techniques will strongly benefit from access to intense, coherent pairs of femtosecond X-ray pulses. We have observed phase-stable X-ray pulse pairs containing mor

Low-lying states in the odd-Z isotopes Ac13289221 and Pa13491225 have been studied using α-particle and αγ-coincidence spectroscopy in the Pa225→Ac221→Fr217 decay chain. Ground-state spin and parity assignments of Iπ = 5/2- are proposed for both Ac221 and Pa225, with the odd proton occupying the ω = 5/2 orbital of the quadrupole-octupole deformed shell model in both nuclei. In Ac221, excited state

PMCA4 is a critical regulator of Ca2+ homeostasis in mammalian cells. While its biological and prognostic relevance in several cancer types has already been demonstrated, only preclinical investigations suggested a metastasis suppressor function in melanoma. Therefore, we studied the expression pattern of PMCA4 in human skin, nevus, as well as in primary and metastatic melanoma using immunohistoch

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the efficacy and safety of diclofenac (any dose) for acute postoperative pain management in children compared with placebo, other active comparators, or diclofenac administered by either different routes (e.g. oral, rectal, etc.) or strategies (e.g. as needed versus as scheduled).