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Recent technological and conceptual advances have resulted in a plethora of exciting novel engineered adeno associated viral (AAV) vector variants. They all have unique characteristics and abilities. This review summarizes the development and their potential in treating Parkinson's disease (PD). Clinical trials in PD have shown over the last decade that AAV is a safe and suitable vector for gene t
Seven genera new to science, i.e.: Helmutiopsis, Huriopsis, Johnsheardia, Klauskalbia, Kudratovia, Kurokawia and Poeltonia of the Physciaceae are proposed for the ‘Rinodina’ atrocinerea, the ‘Rinodina’ xanthophaea, the ‘Rinodina’ cinnamomea, the ‘Heterodermia’ obscurata, the ‘Rinodina’ straussii, the ‘Anaptychia’ isidiata and the ‘Physconia’ grisea groups consequently that all form strongly suppor
Splicing and translation are two of the key steps of post-transcriptional regulation of gene expression. Their tight regulation is essential for development, whereas their deregulation is involved in cancer pathogenesis. Nevertheless, many of the molecular mechanisms controlling these processes are still unknown. Hence, the main aim of this thesis is to elucidate novel regulatory mechanisms that a
Eurasian jays fail to take into account the point of view and desire of other jays when hiding food they can eat later.
The interface between two semiconductors strongly influences the optical and electronic properties of the interface. The type-II interface is characterized by a staggered band alignment, where both valence and conduction band edges in one material are above their counterparts in the other material. A type-II band alignment is formed at the interface between wz and zb segments in homomaterial InP n
Background: In patients with end-stage kidney disease (ESKD), home dialysis offers socio-economic and health benefits compared with in-centre dialysis but is generally underutilized. We hypothesized that the pre-dialysis course and institutional factors affect the choice of dialysis modality after dialysis initiation (DI).Methods: The Peridialysis study is a multinational, multicentre prospective
There is increasing evidence showing the health benefits of physical activity, such as better survival and possibly even a slower decline in kidney function, in people with chronic kidney disease (CKD). There is convincing evidence that exercise training improves physical function measured as aerobic capacity, muscle endurance strength and balance at all ages and all stages of CKD. In fact, long-t
Background: Despite early referral of uraemic patients to nephrological care, suboptimal dialysis initiation (SDI) remains a common problem associated with increased morbimortality. We hypothesized that SDI is related to pre-dialysis care.Methods: In the 'Peridialysis' study, time and reasons for dialysis initiation (DI), clinical and biochemical data and centre characteristics were registered dur
Denna avhandling undersöker empiriskt hur rätten och andra mekanismer för social kontroll under tvångsförsäljning i Sverige är betingade av skillnader i social status. Avhandlingen vilar på den amerikanske sociologen Donald Blacks teori om social kontroll för att förklara denna sociala betingelse. Enligt Black är det möjligt att förklara variationer i olika mekanismer för social kontroll med variaThis thesis empirically investigates how law and other social control responses during foreclosure in Sweden are contingent upon differences in social status. The thesis draws upon American sociologist Donald Black’s theoretical framework on social control to explain this social contingency. According to Black, variations in social control responses are explained and predicted by variations in the
The effects of climate change, whether they be via slow- or rapid-onset events such as extreme events, are inflicting devastating losses and damage on communities around the world, with the most vulnerable affected the most. Although the negative impacts of climate change and the concept of loss and damage are included in international conventions, such as the United Nations Warsaw International M
We conducted a network analysis of measures of dissociation and posttraumatic symptoms (PTS) with a varied sample of adolescents (N = 312), some of them previously exposed to war scenarios. The global measure of dissociation (A-DES) was uniquely linked to the arousal PTS symptom cluster (CRIES-13), in particular sleep problems, but not to the reexperiencing and avoidance clusters. Three of four (i
This study indicates valuable contributions of narrative criticism and rhetorical criticism. Together with the traditional historical-critical approach, these methods can help us toward an interpretation that lets us better understand the purpose and the function of the gospel-story. One purpose is for it to function as an argument in favour of the standpoint that Jesus is the Son of God, the MessThis study indicates valuable contributions of narrative criticism and rhetorical criticism. Together with the traditional historical-critical approach, these methods can help us toward an interpretation that lets us better understand the purpose and the function of the gospel-story. One purpose is for it to function as an argument in favour of the standpoint that Jesus is the Son of God, the Mess
As one of the most important texts of the apostle Paul, Galatians offers a goodstarting-point for an investigation of Paul’s argumentation. The letter is polemical and contains a substantial amount of argumentative passages. Paul evidently wanted to persuade by using the best arguments possible to convince his addressees. Although the argumentation of Paul is often an issue within New Testament exAs one of the most important texts of the apostle Paul, Galatians offers a goodstarting-point for an investigation of Paul’s argumentation. The letter is polemical and contains a substantial amount of argumentative passages. Paul evidently wanted to persuade by using the best arguments possible to convince his addressees. Although the argumentation of Paul is often an issue within New Testament ex
Galatians is a polemical letter which contains a substantial amount of argumentative passages. Paul evidently wanted to persuade by using the best arguments possible to convince his addressees. Using a state-of-the-art method from the discipline of argumentation analysis, Paul's argumentation can be analysed with a precision that standard exegetical methods cannot provide. The pragma-dialectical mGalatians is a polemical letter which contains a substantial amount of argumentative passages. Paul evidently wanted to persuade by using the best arguments possible to convince his addressees. Using a state-of-the-art method from the discipline of argumentation analysis, Paul's argumentation can be analysed with a precision that standard exegetical methods cannot provide. The pragma-dialectical m
Argumentationsteorin i dissertationen Paulus argumentation i Galaterbrevet: en pragma-dialektisk analys.
Pragmadialektiikan maailmanvalloitus alkoi kaksikymmentäviisi vuotta sitten. Tänään se on yhtä tunnettu kuin jo viisikymmentä vuotta täyttäneet Toulminin ja Perelmanin uraauurtavat argumentaation teoriat. Arviot pragmadialektiikasta kuitenkin vaihtelevat huomattavan paljon. J. Anthony Blair on esimerkiksi luonnehtinut sitä maailman tärkeimmäksi argumentaation teoriaksi tänä päivänä. John Woodsin m
