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Mitochondrial components dynamically change in response to environmental and developmental cues. However, the regulatory pathways that underlie these changes are largely unknown. A global analysis of changes in mitochondrial components at the transcript, protein and metabolite levels was undertaken, to gain a greater insight into how mitochondrial functions are regulated and respond to various int
Diurnal regulation of transcripts encoding proteins located in mitochondria, plastids, and peroxisomes is important for adaptation of organelle biogenesis and metabolism to meet cellular requirements. We show this regulation is related to diurnal changes in promoter activities and the presence of specific cis-acting regulatory elements in the proximal promoter region [TGGGC(C/T)], previously defin
Reactive oxygen species and redox signaling undergo synergistic and antagonistic interactions with phytohormones to regulate protective responses of plants against biotic and abiotic stresses. However, molecular insight into the nature of this crosstalk remains scarce. We demonstrate that the hydrogen peroxide-responsive UDP-glucosyltransferase UGT74E2 of Arabidopsis thaliana is involved in the mo
Twelve years after their discovery in plants, prohibitins (PHBs) have retained their status as some of the most enigmatic mitochondrial proteins. Although the original hypothesis that PHBs act as negative cell cycle regulators has lost its impetus in plants, the essential molecular function(s) PHB complexes perform in the inner mitochondrial membrane are now beginning to be understood. We review t
To obtain a global overview of how mitochondria respond to stress, we aimed to define the plant mitochondrial stress response (MSR). By combining a set of 1196 Arabidopsis thaliana genes that putatively encode mitochondrial proteins with 16 microarray experiments on stress-related conditions, 45 nuclear encoded genes were defined as widely stress-responsive. Using green fluorescent protein (GFP) f
When subjected to stress, plants reprogram their growth by largely unknown mechanisms. To provide insights into this process, the growth of Arabidopsis (Arabidopsis thaliana) leaves that develop under mild osmotic stress was studied. Early during leaf development, cell number and size were reduced by stress, but growth was remarkably adaptable, as division and expansion rates were identical to con
Plant cells integrate signals from external sources and from organelles to regulate gene expression, referred to as anterograde and retrograde signaling, respectively. Functional characterization of the promoter of ALTERNATIVE OXIDASE1a (AOX1a) from Arabidopsis (Arabidopsis thaliana), a marker for mitochondrial retrograde response, was carried out by testing the ability of the AOX1a promoter to dr
The alternative oxidase (AOX) is found in all plants examined to date, fungi and lower invertebrates. We propose that AOX is not only part of the stress response in plants, but it also plays a central role in defining the stress response. Three lines of evidence support this proposal: (1) The absence of AOX leads to an alteration of stress defences in normal and stress conditions, (2) the expressi
In this study we analyzed transcript abundance and promoters of genes encoding mitochondrial proteins to identify signaling pathways that regulate stress-induced gene expression. We used Arabidopsis (Arabidopsis thaliana) alternative oxidase AOX1a, external NADP H-dehydrogenase NDB2, and two additional highly stress-responsive genes, At2g21640 and BCS1. As a starting point, the promoter region of
Mitochondrial electron transport pathways exert effects on carbon-nitrogen (C/N) relationships. To examine whether mitochondria-N interactions also influence plant growth and development, we explored the responses of roots and shoots to external N supply in wild-type (WT) Nicotiana sylvestris and the cytoplasmic male sterile II (CMSII) mutant, which has a N-rich phenotype. Root architecture in N.
The Arabidopsis thaliana genome expresses five evolutionarily conserved prohibitin (PHB) genes that are divided into type-I (AtPHB3 and AtPHB4) and type-II (AtPHB1, AtPHB2 and AtPHB6) classes, based on their phylogenetic relationships with yeast PHB1 and PHB2, respectively. Yeast and animal PHBs are reported to have diverse roles in the cell cycle, mitochondrial electron transport, aging and apopt
Koncentrationen av myndigheter i huvudstaden ökar risken för korruption. Staden är stor, men nätverken snäva. Det är en av flera anledningar varför pågående omlokalisering av statsförvaltningens myndigheter till orter utanför Stockholm är nödvändig.
Både medborgare och politiker är trötta på trätandet i dagens politiska debatt. Samtalet måste präglas mer av dialog - annars växer politikerföraktet liksom de populistiska strömningarna. Ytterst riskeras demokratin.
Kravet på samverkan mellan akademi och samhälle är ett bärande inslag i den nya forskningspropositionen. Detta har lett till högljudda protester från landets forskare. Men samverkan är nödvändig och forskare får inte stanna i ett elfenbenstorn. Forskningens distans till samhället kommer nämligen besvaras med samhällets distans till forskningen. Här har vi en del av förklaringen till den ”faktaresi
Two 60-GHz band voltage controlled oscillators (VCOs) designed in a 28-nm ultrathin body and buried oxide fully depleted silicon on insulator (UTBB FD-SOI) CMOS process are demonstrated and compared. Both VCOs have identical cross-coupled nMOS cores and dissipate 3.15 mW from a 0.9-V supply. The first design uses a standard FET current source and achieves a figure of merit (FOM) of −181 dBc/Hz, wh
1970-talets känslomönster utmärktes av en dröm om mänsklig gemenskap och befrielse från fördomar samt en vilja att komma i kontakt med sig själv och andra, att söka det äkta, det naturliga, det autentiska och nå en öppenhet. Man ville att det skulle kännas på ett visst sätt att arbeta, vila, skapa, vara solidarisk, konsumera, ha sex, vara barn, förälder, man och kvinna, ung och gammal, överordnad
The assessment of the free water fraction in the brain provides important information about extracellular processes such as atrophy and neuroinflammation in various clinical conditions as well as in normal development and aging. Free water estimates from diffusion MRI are assumed to account for freely diffusing water molecules in the extracellular space, but may be biased by other pools of molecul
