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Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer : A pooled analysis of data from two prospective cohort studies

Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melb

The short isoform of PRLR suppresses the pentose phosphate pathway and nucleotide synthesis through the NEK9-Hippo axis in pancreatic cancer

Prolactin binding to the prolactin receptor exerts pleiotropic biological effects in vertebrates. The prolactin receptor (PRLR) has multiple isoforms due to alternative splicing. The biological roles and related signaling of the long isoform (PRLR-LF) have been fully elucidated. However, little is known about the short isoform (PRLR-SF), particularly in cancer development and metabolic reprogrammi

Upscaling Northern Peatland CO2 Fluxes Using Satellite Remote Sensing Data

Peatlands play an important role in the global carbon cycle as they contain a large soil carbon stock. However, current climate change could potentially shift peatlands from being carbon sinks to carbon sources. Remote sensing methods provide an opportunity to monitor carbon dioxide (CO2) exchange in peatland ecosystems at large scales under these changing conditions. In this study, we developed ePeatlands play an important role in the global carbon cycle as they contain a large soil carbon stock. However, current climate change could potentially shift peatlands from being carbon sinks to carbon sources. Remote sensing methods provide an opportunity to monitor carbon dioxide (CO2) exchange in peatland ecosystems at large scales under these changing conditions. In this study, we developed e

Combined Use of Aspirin and Selective Serotonin Reuptake Inhibitors Is Associated With Lower Risk of Colorectal Cancer : A Nested Case-Control Study

INTRODUCTION: Chemoprevention against colorectal cancer (CRC) is greatly needed. As the development of CRC involves multiple dysfunctional pathways, it is thus reasonable to combine some agents that address several pathways to achieve better chemoprotection. We aimed to explore whether the use of aspirin and selective serotonin reuptake inhibitors (SSRIs)-either as monotherapy or combined-can have

Atomic Data Needs in Astrophysics: The Galactic Center “Scandium Mystery”

Investigating the Galactic center offers unique insights into the buildup and history of our Galaxy and is a stepping stone to understand galaxies in a larger context. It is reasonable to expect that the stars found in the Galactic center might have a different composition compared to stars found in the local neighborhood around the Sun. It is therefore quite exciting when recently there were repo

Temperature thresholds of ecosystem respiration at a global scale

Ecosystem respiration is a major component of the global terrestrial carbon cycle and is strongly influenced by temperature. The global extent of the temperature–ecosystem respiration relationship, however, has not been fully explored. Here, we test linear and threshold models of ecosystem respiration across 210 globally distributed eddy covariance sites over an extensive temperature range. We fin

Comparison of Five Formulations for Evaluating Q Factors of Antennas

There are several formulations for calculating the Q factors of antennas. The evaluated Q factors are not always in agreement because of the differences in the definition of Q factor and the method in addressing the stored reactive energies. This paper gives a short comparison of five of them with numerical examples.

Spatial Coupling in Turbo Equalization

In this paper we consider spatial coupling in turbo equalization and demonstrate that the code design trade-off between the performance in waterfall and error floor regions can be avoided. We introduce three coupling schemes and compare their performances, where the first method introduces coupling between the encoder and the channel, while the second uses a spatially coupled (SC) code. In the thi

On the Complexity Requirements of a Panel-Based Large Intelligent Surface

A Large Intelligent Surface (LIS) is a recently proposed concept, especially suitable for high speed indoor communications and industrial internet of things (IoT) applications. Basing the LIS on smaller panels has clear advantages in terms of flexibility and mass production of its elements. In this paper we consider a panel-based LIS and we study the interplay of the panel size, the number of base

Acoustic design of ordinary rooms using absorbers and diffusers

With different activities in a room, room acoustic requirements differ and when the acoustic requirements are different, acoustic treatment must be adapted. This study focuses on room acoustics in ordinary public rooms such as classrooms and offices. By tradition the acoustic treatment in these rooms is an absorbent ceiling. Experiments have been carried out in a classroom where the baseline in th

Epsilon waves as an extreme form of depolarization delay : Focusing on the arrhythmogenic right ventricular cardiomyopathy/dysplasia

Revision of the Task Force diagnostic criteria (TFC) for arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D), in 2010, has increased the sensitivity for the diagnosis of early and familial forms of the disease. Epsilon wave (EW) is a major diagnostic criterion in the context of ARVC/D, however, it remains unquantifiable and therefore, may leave room for substan-tial subjective inter

Effects of Sex on Early Outcome following Repair of Acute Type A Aortic Dissection : Results from the Nordic Consortium for Acute Type A Aortic Dissection (NORCAAD)

Background Female sex is known to have increased perioperative mortality in cardiac surgery. Studies reporting effects of sex on outcome following surgical repair for acute Type A aortic dissection (ATAAD) have been limited by small cohorts of heterogeneous patient populations and have shown diverging results. This study aimed to compare perioperative characteristics, operative management, and pos

Mayr Versus Woese : Akaryotes and Eukaryotes

In 1998, on the brink of a great public effort that by now has delivered the sequences of thousands of genomes and has annotated these genomes by translating tens of thousands of 3D protein domain structures from their coding sequences, Ernst Mayr and Carl Woese engaged in a debate. At issue were the virtues of phenotypic contra genotypic approaches to phylogeny and taxonomy. Though not conclusive

Applying the ecosystem model in a new context? The case of business incubation in Oman

This paper studies entrepreneurship ecosystem development in a context little discussed in the extant literature to date: Oman. Specifically, it focuses on business incubation (BI) initiatives as a policy tool for developing the local, regional, and national systems of supporting entrepreneurship and SME growth. Although BI’s are a popular policy measure for ecosystem development, spreading global