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Late specialization: the key to success in centimeters, grams, or seconds (cgs) sports
Multi-Stakeholder Partnerships for Sustainable Development: Rethinking Legitimacy, Accountability and Effectiveness
Exploring consumer attitudes to alternative models of consumption: motivations and barriers
The Harm in Hate Speech and in Holocaust Denial
This chapter begins by providing a general contextualisation of hate speech and the controversies around it. It then asks two questions: Is Holocaust denial a form of hate speech? If the answer is positive, should Holocaust denial be banned?The second section explains what is hate speech. The third section is concerned with the relationship between hate speech and hate crime. The fourth section di
Liposomal formulation of a new antifungal hybrid compound provides protection against Candida auris in the ex vivo skin colonization model.
The newly emerged pathogen, Candida auris, presents a serious threat to public health worldwide. This multidrug-resistant yeast often colonizes and persists on the skin of patients, can easily spread from person to person, and can cause life-threatening systemic infections. New antifungal therapies are therefore urgently needed to limit and control both superficial and systemic C. auris infectio
Missing Mum : Reframing Imprisoned Childhoods in Autobiography and Activism in the Iranian Context
This chapter studies the entanglements of autobiographical writing with activism in the work of Hamed Farmand (1976–), an Iranian child rights activist who lives in the diaspora. Farmand spent five years of his childhood in 1980s Iran without his mother, who was a political prisoner during this period. As an adult, he began reflecting on this experience and writing about his life across different
High prevalence of atrial conduction abnormalities in Lewy body disease – a marker of cardiac complications?
Increasing evidence suggests that Lewy body disease (LBD) is associated with clinically important cardiac complications, including sick sinus syndrome, atrial fibrillation and sudden cardiac death. The high prevalence of sick sinus syndrome and atrial fibrillation in LBD suggests the presence of disease-related atrial conduction disorders. To explore whether LBD is associated with atrial conductio
Self-Efficacy in Hypertension Management Using e-Health Technology : A Randomized Controlled Trial in Primary Care
Self-efficacy is tightly intertwined with person-centered care and correlates with engaging in self-care behaviors, an important part of hypertension treatment. Evidence indicates that e-Health-based self-management interventions could increase self-efficacy. The objectives of this study were to investigate whether an intervention with a person-centered approach supported by e-Health technology ca
Women’s experience of gestational diabetes and healthcare in southern Sweden – a qualitative study
Background: Gestational diabetes is one of the most common pregnancy complications, affecting 14% of all pregnancies globally, and its prevalence is increasing. Gestational diabetes is associated with short and long-term complications for both the mother and their offspring, which are possible to prevent by glycemic control mainly facilitated by healthy lifestyle behaviors. Hence, women diagnosed
Genetic and Environmental Determinants of Early Vascular Ageing (EVA).
Cardiovascular disease is multidimensional and new ideas are needed to develop the conventional risk factor paradigm that has been based on the Framingham Heart Study since more than 30 years. Traditional risk factors such as hypertension, smoking, hyperlipidemia and diabetes can only explain about 50% of the distribution of coronary heart disease whereas the inclusion of new risk markers or prote
Stress resilience and subsequent risk of type 2 diabetes in 1.5 million young men.
Psychosocial stress in adulthood is associated with a higher risk of type 2 diabetes, possibly mediated by behavioural and physiological factors. However, it is unknown whether low stress resilience earlier in life is related to subsequent development of type 2 diabetes. We examined whether low stress resilience in late adolescence is associated with an increased risk of type 2 diabetes in adultho
Early vascular aging (EVA): consequences and prevention.
It has often been recognized that a discrepancy exists during the clinical consultation between the chronological age of a patient on the one hand with the signs and symptoms of biological age that can be recorded on the other hand. In cardiovascular medicine this is obvious when a heavy smoker presents with features of early biological aging, for example skin appearance and impaired lung function
Molecular Function of TCF7L2: Consequences of TCF7L2 Splicing for Molecular Function and Risk for Type 2 Diabetes.
TCF7L2 harbors the variant with the strongest effect on type 2 diabetes (T2D) identified to date, yet the molecular mechanism as to how variation in the gene increases the risk for developing T2D remains elusive. The phenotypic changes associated with the risk genotype suggest that T2D arises as a consequence of reduced islet mass and/or impaired function, and it has become clear that TCF7L2 plays
Blue intensity and density from Northern Fennoscandian tree rings, exploring the potential to improve summer temperature reconstructions with earlywood information
Here we explore two new tree-ring parameters, derivedfrom measurements of wood density and blue intensity(BI). The new proxies show an increase in the interannualsummer temperature signal compared to establishedproxies, and present the potential to improve long-term performance.At high latitudes, where tree growth is mainlylimited by low temperatures, radiodensitometric measurementsof wood density
SATB2 in Combination With Cytokeratin 20 Identifies Over 95% of all Colorectal Carcinomas.
The special AT-rich sequence-binding protein 2 (SATB2), a nuclear matrix-associated transcription factor and epigenetic regulator, was identified as a tissue type-specific protein when screening protein expression patterns in human normal and cancer tissues using an antibody-based proteomics approach. In this respect, the SATB2 protein shows a selective pattern of expression and, within cells of e
Human oral, gut, and plaque microbiota in patients with atherosclerosis
Periodontal disease has been associated with atherosclerosis, suggesting that bacteria from the oral cavity may contribute to the development of atherosclerosis and cardiovascular disease. Furthermore, the gut microbiota may affect obesity, which is associated with atherosclerosis. Using qPCR, we show that bacterial DNA was present in the atherosclerotic plaque and that the amount of DNA correlate
The presence and meaning of chronic sorrow in patients with multiple sclerosis.
Balanced Truncation for a General Class of Discrete-Time Markov Jump Linear Systems
This paper develops a generalization of the balanced truncation algorithm applicable to discrete-time Markov jump linear systems. The approximation error, which is captured by means of the stochastic L2 gain, is bounded from above by twice the sum of singular numbers associated to the truncated states of each mode.