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Severe infections continue to constitute a large burden, with high mortality and risk of sequelae. Sepsis is a dysregulated host response to an infection that causes life threatening organ damage. Meningitis is a severe infection of the brain that often leads to sepsis and death or lasting neurological damage. The host response is often responsible for more damage than the pathogen itself. This th
Background Increased vascular permeability is a key feature in the pathophysiology of sepsis and the development of organ failure. Shedding of the endothelial glycocalyx is increasingly being recognized as an important pathophysiological mechanism but at present it is unclear if glypicans contribute to this response. We hypothesized that plasma levels of glypicans (GPC) are elevated in patients wi
Background Acute bacterial meningitis is a disease with a high mortality and a high incidence of neurological sequelae in survivors. There is an acute need to develop new adjuvant therapies. To ensure that new therapies evaluated in animal models are translatable to humans, studies must evaluate clinically relevant and patient-important outcomes, including neurological symptoms and sequelae. Meth
Boken bygger på de grundläggande värderingar och begrepp som socialtjänstlagstiftningen vilar på. Vidare finns både bakgrund och kommentarer till lagarna inom socialtjänstens område och de övriga lagar och förordningar som ansluter till dessa. Denna klassiker föreligger nu i sin 14:e upplaga och är grundligt reviderad av Monica Larsson, jurist och universitetslektor i socialt arbete. Den nya upplaBoken bygger på de grundläggande värderingar och begrepp som socialtjänstlagstiftningen vilar på. Vidare finns både bakgrund och kommentarer till lagarna inom socialtjänstens område och de övriga lagar och förordningar som ansluter till dessa. Denna klassiker föreligger nu i sin 14:e upplaga och är grundligt reviderad av Monica Larsson, jurist och universitetslektor i socialt arbete. Den nya uppla
State reforms adopted in the 1680s prevented the largest copperworks in the Oldenburg Monarchy, Røros, from shutdown. The changes ensured supply deliveries and regular wage payments through spread of ownership, delegating more responsibilities to the Director and managers and introducing complex control mechanisms and state monitoring of the accounts and daily tasks. They appear relatively advance
III-V vertical nanowire MOSFETs (VNW-FETs) have the potential to extend Moore’s law owing to their excellent material properties. To integrate highly scaled memory cells coupled with high performance selectors at minimal memory cell area, it is attractive to integrate low-power resistive random access memory (RRAM) cells directly on to III-V VNW-FETs. In this work, we report the experimental demon
A green route for the production of 6-carbon polymer building blocks 6-hydroxyhexanoic acid, adipic acid and ϵ-caprolactone from 1,6-hexanediol, a hydrogenation product of biobased 5-hydroxymethylfurfural is reported. Gluconobacter oxydans oxidized 1,6-hexanediol completely to adipic acid, and selectively at pH 6-7 to 6-hydroxyhexanoic acid, which was converted to ϵ-caprolactone by catalytic cycli
Mobile communications have been undergoing a generational change every ten years or so. However, the time difference between the so-called "G's" is also decreasing. While fifth-generation (5G) systems are becoming a commercial reality, there is already significant interest in systems beyond 5G, which we refer to as the sixth-generation (6G) of wireless systems. In contrast to the already published
A highly standardized 99mTc-sulphur colloid was used to evaluate reticuloendothelial system (RES)-function in the normal rat and after RE blockade by gelatin (Haemaccel). Activity distribution in the animals was measured with a scintillation camera technique. Total uptake of activity in the liver was estimated. From the time-activity curves over the liver, the phagocytic index (kphag) was evaluate
Activated charcoal traps are used in nuclear medicine departments to capture exhaled radioactive xenon gas. In the present study, the trapping performance of charcoal was investigated for different physical qualities in experimental and clinical situations. Various factors affecting the trapping capacity are identified, such as the charcoal mass, moisture and carbon�dioxide concentrations in the
A low-cost microprocessor-based temperature controller for hyperthermia experiments on rats is described. The system directs a microwave generator, used for heating, by feedback power regulating signals in accordance with the temperature in the animal. The microwave power is pulsed for short on-and-off periods and the temperature recordings are carried out during the off periods. More than 300 hyp
A quantitative kinetic technique using a scintillation camera has been developed for investigating lymph drainage and the uptake in the lymph nodes of 99mTcSb2S3 colloid injected subcutaneously. Twenty-two patients with primary malignant melanoma were examined. Lymph-node dissection was performed and 185 lymph nodes were individually measured for radioactivity. The kinetics of colloid uptake in in
Methods are reviewed for measuring xenon-133 contamination of the air in medical clinics. The principles of a new, simple, and low cost monitor are outlined. Results from experimental tests in laboratories and medical clinics were encouraging, indicating that the monitor is a valuable tool for survey measurements of 133Xe contamination in nuclear medicine departments.
Gel chromatography column scanning (GCS) is a rapid and reliable method for the quality control of 99mTc-radiopharmaceuticals. With this method the labelled compound and various impurities such as free pertechnetate, hydrolyzed reduced technetium or other 99mTc-complexes are obtained in one testing procedure. Using minicolumns results can be obtained with a simple testing procedure within a few mi
The effects of infused glucagon, histamine and vasopressin on blood flow in anesthetized rats with intrahepatic tumors were studied using microspheres labelled with 99Tcm or 51Cr isotopes. Considerable circulatory effects were noted both in central hemodynamic parameters as well as in organ and tissue blood flows. Glucagon infusion increased blood flow in the spleen and small intestine while hepat
Subcutaneously implanted tumors in Wistar and Lister rats were used as a model for the study of metastatic tumor blood flow and how it is affected by vasoactive drugs. Blood flow measurements were obtained using the labelled microsphere method and the reference organ technique. Microspheres (15‐μm) labelled with either 99Tcm or 51 Cr isotopes were injected intracardially and a reference sample was
The activity-size distribution of radiocolloids has been studied using gel-chromatography scanning (GCS) of columns filled with Sepharose 4B gel. Rabbits were injected subcutaneously with the colloid of interest, laid supine beneath a gamma camera, and imaged every 15 sec for 2 to 4 hr. From the stored data, the uptakes in the parasternal lymph nodes were analyzed in terms of a two-compartment mod
The cardiac output and regional blood flow have been simultaneously determined in the anesthetized rat by using the reference organ method. 99Tcm labelled dextran 15 μm microspheres were injected in the left ventricle while simultaneously an arterial reference sample was drawn at constant known rate. The values calculated regarding cardiac output agree well with previously recorded series. Regiona
