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Drug resistance remains a critical challenge in cancer chemotherapy, particularly in oral squamous cell carcinoma (OSCC). Recent findings have highlighted the significant roles that autophagy and extracellular vesicles (EVs) play in contributing to chemoresistance. In previous studies, we demonstrated that EVs are essential in mediating cisplatin resistance in human OSCC cells. In this study, we s

Vår relation till miljö och natur blir alltmer beroende av digitala hjälpmedel men vad är det för data som används och vem är det som mäter?

Chlorophyll-a (Chl-a) is one of the critical water quality indicators that shows the eutrophication status of aquatic ecosystems. As the largest lake and a well-known attraction in middle Europe, Lake Balaton contributes 70 % or more of local economy through tourism, while also maintaining a unique biodiversity. Therefore, long-term monitoring of water quality is essential for its effective manage

Background: The response to the COVID-19 pandemic involved various lockdown measures, including school closures, which significantly impacted young populations, particularly in low-and middle-income countries (LMICs). Given the well-known protective effect of regular school attendance on sexual and reproductive health and rights (SRHR), reports of disrupted education, compromised SRHR, and an incr

Background: Multimorbidity is increasing globally, affecting over one-third of the population. Adults with complex needs often experience physical, mental, and cognitive disorders, leading to increased healthcare utilization, reduced quality of life, and social challenges. The frequent co-occurrence of psychiatric conditions, substance abuse, addiction, and homelessness highlights the complexity o

Parkinson’s disease (PD) is a complex neurodegenerative disease with a largely unknown etiology. Although the loss of dopaminergic neurons in the substantia nigra pars compacta is the pathological hallmark of PD, neuroinflammation also plays a fundamental role in PD pathology. We have previously reported that PD patients have increased frequencies of T cells reactive to peptides from α-synuclein (

Selective inheritance of sub-cellular components has emerged as a mechanism guiding stem cell fate after asymmetric cell divisions. Peroxisomes play a crucial role in multiple metabolic processes such as fatty acid metabolism and reactive oxygen species detoxification, but the apportioning of peroxisomes during stem cell division remains understudied. Here, we develop a mouse model and labeling te

Stress granules (SGs) are membraneless organelles formed in the cellular cytoplasm under stressful conditions through liquid–liquid phase separation (LLPS). SG assembly can be both dependent and independent of the eIF2α pathway, whereas cellular protein quality control systems mediate SG disassembly. Chaperones and specific domains of RNA-binding proteins strongly contribute to the regulation SG d

Purpose: Abdominal wall complications can be reduced by adhering to guidelines for midline laparotomy closure. However, implementation of guidelines can be challenging. To address this issue, a laparotomy closure device for swift and standardized abdominal closure was developed. The study evaluated the quality of the suture, safety, and speed of the device in a clinical setting. Methods: A prospec

Background: Both aging and Alzheimer's disease (AD) affect brain networks, with early disruptions occurring in regions involved in episodic memory. Few studies have, however, focused on distinguishing region-specific effects of AD-biomarker negative “normal” aging and early amyloid- and tau pathology on functional connectivity. Further, longitudinal studies combining imaging, biomarkers, and cogni

Bladder cancer (BLCA) and diabetes mellitus (DM) are two prevalent diseases that may share molecular mechanisms, suggesting potential links between metabolic disorders and cancer. Using bioinformatics approaches, we integrated multiple databases to identify common genes between BLCA and DM, screening for potential biomarkers. CXCL12 (C-X-C motif chemokine 12, also known as stromal cell-derived fac

Background: Cataracts are the leading cause of reversible blindness globally, disproportionately affecting populations in low- and middle-income countries. In Ethiopia, cataracts remain a significant public health concern. Despite the effectiveness of cataract surgery in restoring vision, information on recovery time and its predictors remain limited. The aim of this study was to assess time to re

The Multipole Injection Kicker (MIK) installed in the 3 GeV ring of MAX IV, is a success story in the use of a non-linear field device ensuring an almost transparent injection into the first ever built fourth-generation storage ring. Reducing the transient stored beam perturbations during top-up injections is particularly relevant for such machines operating at emittances in the regime of few hund

Background: Children aged 0–18 years who need long-term respiratory support rely on medical technology and comprehensive medical care. For this care to be provided at home, access to medical and social support and care is essential. In Sweden, the most notable form is personal care assistance (PCA), which is granted based on legislation and individual authority decisions. We aim to explore the imp

Diagnosing sepsis in critical care remains a challenge due to the lack of gold-standard diagnostics. Calprotectin (S100A8/A9) has been proposed as a diagnostic marker to identify sepsis in critically ill patients. This study evaluated the diagnostic performance of calprotectin and C-reactive protein (CRP) to distinguish between sepsis and non-sepsis on intensive care unit (ICU) admission. Admissio

Two-dimensional electron liquids (2DELs) have increasing technological relevance for ultrafast electronics and spintronics, yet significant gaps in their fundamental understanding are exemplified on the prototypical SrTiO3. We correlate the exact SrTiO3(001) surface structure with distinct 2DELs through combined microscopic angle-resolved photoemission spectroscopy and non-contact atomic force mic

Purpose: The aim of this study was to translate the health-related quality-of-life questionnaire EORTC QLQ-LMC21 into Swedish and to test its clinical and psychometric reliability and validity in patients with liver metastases from colorectal cancer (CRC) undergoing surgical treatment. Methods: The Swedish versions of the EORTC QLQ-C30 and EORTC QLQ-LMC21 were administered to 250 patients with liv

We exhibit supercritical trade-off for monotone circuits, showing that there are functions computable by small circuits for which any small circuit must have depth superlinear or even super-polynomial in the number of variables, far exceeding the linear worst-case upper bound. We obtain similar trade-offs in proof complexity, where we establish the first size-depth trade-offs for cutting planes an

Background: Fetal exposure to endocrine-disrupting chemicals (EDCs) has been associated with reduced male fecundity, but with few studies considering chemical mixtures. Objectives: We assessed the association between fetal exposure to a mixture of EDCs and biomarkers of male fecundity in young adulthood. Materials and methods: The study population comprised 841 young adult males enrolled in the Fe

Introduction: Snus is suggested as a risk factor for cardiometabolic disease, but little is known about health effects in young populations, particularly in women. We aimed to investigate associations between snus and cardiometabolic health markers among young men and women. Aims and Methods: This study was conducted within the BAMSE (Swedish acronym for Children, Allergy, Environment, Stockholm,