BACKGROUND: Analysis of circulating tumor cells (CTC) is a promising prognostic marker in castration-resistant prostate cancer (CRPC). The aim of this study was to investigate CTC detection and phenotyping as prognostic biomarkers for response to primary androgen deprivation therapy (ADT) of metastatic prostate cancer (PC). METHODS: PC patients presenting with a prostate specific antigen (PSA) >80

An exocrine pancreatic insufficient (EPI) pig model was used in the study. The effects of milk formula pre-digestion with immobilized microbial lipase, on the absorption and tissue accretion of long chain polyunsaturated fatty acids (LCPUFA) were assessed. Thirteen male EPI pigs, 10 weeks of age, were used in the study. Six healthy pigs, 6 weeks of age, were used as controls. The pigs were fed eit

The orchid family is the largest in the angiosperms, but little is known about the molecular basis of the significant variation they exhibit. We investigate here the transcriptomic divergence between two European terrestrial orchids, Dactylorhiza incarnata and Dactylorhiza fuchsii, and integrate these results in the context of their distinct ecologies that we also document. Clear signals of lineag

Gallium nitride based light-emitting diodes (LEDs) are presently fundamentally transforming the lighting industry, but limitations in the materials and fabrication methods of LEDs introduce substantial challenges to their future development. Among the remaining key bottlenecks of GaN LEDs are the resistive losses and current crowding that strongly increase the heat generation at high powers. In th

The relationship between land-use and floristic diversity in the landscape, for the last millennia, is analysed from two small lakes in southern Sweden. Pollen analysis and the Local Vegetation Estimates (LOVE) model are used to quantify land-cover at local scales with 100-year time windows. Floristic richness is estimated using palynological richness, and we introduce LOVE-based evenness as a pro

Six Cr-spinel grains from NWA 6077 brachinite-like and NWA 725 winonaite achondrites have been studied by single-crystal X-ray diffraction and structural refinement. From a chemical point of view, spinels from NWA 6077 show Cr/(Cr + Al) (i.e., Cr#) and Mg/(Mg + Fe2+) (i.e., Mg#) values similar to other brachinites, while the Cr# of NWA 725 is lower than that of literature winonaites. Spinels from

The sedimentation of an ideal suspension in a vessel with variable cross-sectional area can be described by an initial-boundary value problem for a scalar nonlinear hyperbolic conservation law with a nonconvex flux function and a weight function that depends on spatial position. The sought unknown is the local solids' volume fraction. For the most important cases of vessels with downward-decreasin

The millimeter-wave phased array in the user equipment (UE) for 5G communication is studied in this letter. In particular, the body effect on the phased array in the UE at 15 GHz is investigated with the 3-D measurement data, and its impact on some key parameters for phased array in the UE, such as the total scan pattern, the coverage efficiency, and the probability of detection, are analyzed.

The interpretation of whether a dated metamorphic zircon generation grew during the prograde, peak or retrograde stage of a metamorphic cycle is critical to geological interpretation. This study documents a case at Herrestad, in the eastern part of the 1±0 Ga Sveconorwegian Province, involving progressive metamorphic recrystallization of gabbro to garnet amphibolite and associated behaviour of Zr-

The intestinal immune system has the daunting task of protecting us from pathogenic insults while limiting inflammatory responses against the resident commensal microbiota and providing tolerance to food antigens. This role is particularly impressive when one considers the vast mucosal surface and changing landscape that the intestinal immune system must monitor. In this review, we highlight regio

To increase the productivity in biopharmaceutical production, a natural step is to introduce integrated continuous biomanufacturing which leads to fewer buffer and storage tanks, smaller sizes of integrated unit operations, and full automation of the operation. The main contribution of this work is to illustrate a methodology for design and control of a downstream process based on integrated colum

Different ways of viewing human-nature interactions affect the ways in which these are conceptualized and operationalized with regards to cultural ecosystem services (CES). To clarify if some conceptualizations provide more appropriate descriptions of benefits, these need to be discussed in relation to the lived experience. This paper addresses some aspects of the controversy around the use of the

Severe unrestrained behaviors during armed conflicts, such as the massacre in My Lai or abusive transgressions such as the torture-like behaviors occurring in Abu-Ghraib prison, often lead to increased difficulties to decrease hostilities or to gain a peaceful ending to a military conflict. Therefore, it is of highest relevance to understand which individual, situational and organizational factors

The spatial extent of ecological processes has consequences for the generation of ecosystem services related to them. However, management often fails to consider issues of scale when targeting ecological processes underpinning ecosystem services generation. Here, we present a framework for conceptualizing how the amount and spatial scale (here discussed in terms of extent) of management interventi

The effect of the buffer formulation in terms of buffer identity and ionic strength on the interaction between chicken egg lysozyme and carboxyl-modified polystyrene nanoparticles has been systematically studied. The time evolution of the fluorescence of a reporter molecule shows that lysozyme interacts with the nanoparticles in all the studied conditions. The interaction results in changes in pro

Methanol as an alternative fuel in internal combustion engines has an advantage in decreasing emissions of greenhouse gases and soot. Hence, developing of a high performance internal combustion engine operating with methanol has attracted the attention in industry and academic research community. This paper presents a numerical study of methanol combustion at different start-of-injection (SOI) in

Low temperature combustion modes, such as Homogeneous Charge Compression Ignition (HCCI) and Partially Premixed Combustion (PPC), have been researched over recent decades since the concepts show promise for high efficiency and low emissions compared to conventional diesel combustion. PPC is an intermediate combustion type ranging from HCCI-like combustion to diesel-like combustion. The purpose of

Gasoline partially premixed combustion (PPC) has shown potential in terms of high efficiency with low emissions of oxides of nitrogen (NOx) and soot. Despite these benefits, emissions of unburned hydrocarbons (UHC) and carbon monoxide (CO) are the main shortcomings of the concept. These are caused, among other things, by overlean zones near the injector tip and injector dribble. Previous diesel lo