Aims: Metabolic dysfunction is involved in modulating the disease process in Huntington disease (HD) but the underlying mechanisms are not known. The aim of this study was to investigate if the metabolic regulators sirtuins are affected in HD. Methods: Quantitative real-time polymerase chain reactions were used to assess levels of SIRT1-3 and downstream targets in post mortem brain tissue from HD

Purpose: A cost minimisation analysis compares the costs of different interventions’ to ascertain the least expensive over time. We compared different prostate targeted drug treatments with TURP to identify the optimal cost saving duration of a medical therapy for symptomatic benign prostatic enlargement (BPE). Methods: The Evolution registry is a prospective, multicentre registry, conducted by th

Migration usually consists of intermittent travel and stopovers, the latter being crucially important for individuals to recover and refuel to successfully complete migration. Quantifying how sickness behaviours influence stopovers is crucial for our understanding of migration ecology and how diseases spread. However, little is known about infections in songbirds, which constitute the majority of

Understanding how ecosystem services interact to support crop yield is essential for achieving food security. Here we evaluate the interactions among biotic pest regulation, pollination, and nutrient cycling. We found only 16 studies providing 20 analyses of two-way interactions. These studies show that multiple services limit crop yield simultaneously. Complementary effects (no interactions) betw

This paper presents a resistor-less high-precision, sub-1 V all-CMOS voltage reference. A curvature-compensation method is used to cancel the logarithmic temperature dependence regardless of mobility temperature exponent (γ). The circuit is simulated in 65 nm CMOS technology and yields an output voltage of 594 mV, temperature coefficient of 7ppm∘C in the range of −40 to 125 °C, a power supply reje

Several countries have carried out surveys of managed honeybee colonies, the results of which suggest high loss rates all over the world. Although Latin America is an important apicultural region, estimates of honeybee colony losses are lacking. This study quantified colony losses in Argentina during the 2015-16 season. Overall, the survey included 28,204 honeybee colonies, of which 15.5% were rec

Background. Multiple studies have demonstrated that partitioning of molecular datasets is important in model-based phylogenetic analyses. Commonly, partitioning is done a priori based on some known properties of sequence evolution, e.g. differences in rate of evolution among codon positions of a protein-coding gene. Here we propose a new method for data partitioning based on relative evolutionary

The influence of an applied magnetic field on the collective dynamics of novel anisotropic colloidal particles whose shape resembles peanuts is reported. Being made up of hematite cores and silica shells, these micrometer-sized particles align in a direction perpendicular to the applied external magnetic field, and assemble into chains along the field direction. The anisotropic dynamics of these p

In an era defined by insecurity, uncertainty, and increasing anxieties, ontological security has proven to be a fruitful lens for analyzing world politics. This Special Issue joins other recent compilations, contributing to the growing research agenda on ontological security and insecurity in world politics. The articles herein conceptualize and apply ontological security at the international, tra

Do female representatives participate less often in legislative debates, and does it matter which topic is debated? Drawing on the role incongruity theory, we hypothesise that women take the parliamentary floor less often because of the gender stereotypes that are likely to guide the behaviour of party representatives. Such underrepresentation is less likely to be present when debates are dealing

We formulate and prove finite dimensional analogs for the classical Balian–Low theorem, and for a quantitative Balian–Low type theorem that, in the case of the real line, we obtained in a previous work. Moreover, we show that these results imply their counter-parts on the real line.

We combine routine activity theory, lifestyle-victimization theory, and a social network perspective to examine crime victimization. In particular, we study to what extent crime victimization is associated with having close contacts who have been victimized and/or who engage in risky lifestyles. We use the data (collected in 2014) of 1,051 native Swedes and 1,108 Iranian and Yugoslavian first- or

Background: Diminished foot somatosensation contributes to balance deficits and increased fall risk. However, it remains unclear if the 256-Hz tuning fork is adequate to measure, in the outpatient clinical setting, somatosensation in relatively healthy elderly. Aims/Objectives: To evaluate the performance of the 256-Hz tuning fork compared to other measures of somatosensation and balance. Material

Essentials Knowledge of genetic regulators of plasma factor VII activating protease (FSAP) levels is limited. We performed a genome-wide analysis of variants influencing FSAP activity in Scandinavian cohorts. We replicated an association for Marburg-1 and identified an association for a HABP2 stop variant. We identified a novel locus near ADCY2 as a potential additional regulator of FSAP activity.

Försvarsadvokaters arbete utspelar sig i emotionellt laddade men emotionellt begränsade situationer. Detta är särskilt påtagligt i brottmålsrättegångar. Upprivna klienter, oförutsebara avbrott, skakande bevis, emotionella målsägande, till och med moralisk misstänksamhet förväntas hanteras på ett korrekt och passande sätt. Den här avhandlingen analyserar hur detta görs i en svensk kontext, med specDefence lawyers’ work takes place in emotionally charged, yet emotionally constraining situations. This is particularly evident in criminal trials. Distressed clients, unforeseeable disruptions, disturbing evidence, emotional plaintiffs and even moral suspicions should all be managed in a proper and appropriate manner. Loyalty Work analyses how this is done in the context of Sweden, with specific