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Which advanced heart failure therapy strategy is optimal for patients over 60 years old?

BACKGROUND: The optimal advanced heart failure (HF) therapy strategy for patients aged 60 or older with end-stage HF refractory to optimal medical therapy remains uncertain. This study compares outcomes of three advanced HF therapy strategies in this patient population. METHODS: A single-center retrospective study was conducted in 95 patients aged 60-73 years who had undergone isolated heart trans

Tolerability of subcutaneous immunoglobulin 20%, Ig20Gly, in pediatric patients with primary immunodeficiencies

Aim: To assess Ig20Gly tolerability in pediatric patients with primary immunodeficiencies. Patients & methods: Infusion parameters and tolerability were analyzed in pediatric patients (aged 2-5 years [n = 6], 6-11 years [n = 22] and 12-17 years [n = 22]) receiving Ig20Gly in two Phase II/III trials. Results: Of 2624 Ig20Gly infusions, >99% did not require any rate reduction, interruption or di

Antipsychotic Treatment Associated With Increased Mortality Risk in Patients With Dementia. A Registry-Based Observational Cohort Study

Objective: To assess all-cause mortality patients with dementia treated with typical and atypical antipsychotic drugs (APDs). Design: Registry-based cohort study. Setting and participants: A total of 58,412 patients diagnosed with dementia and registered in the Swedish Dementia Registry were included in the study. Of the study sample, 2526 of the patients were prescribed APDs. Of these, 602 patien

Zinc export results in adaptive zinc tolerance in the ectomycorrhizal basidiomycete Suillus bovinus

On Zn-polluted soils, populations of the ectomycorrhizal basidiomycete Suillus bovinus exhibit an elevated Zn tolerance when compared to populations on non-polluted sites. To elucidate the mechanism of Zn tolerance, the time-course of Zn uptake was studied in isolates with contrasting Zn tolerance. Unidirectional fluxes and subcellular compartmentation of Zn were investigated through radiotracer f

Comparison and validation of some ITS primer pairs useful for fungal metabarcoding studies

Current metabarcoding studies aiming to characterize microbial communities generally rely on the amplification and sequencing of relatively short DNA regions. For fungi, the internal transcribed spacer (ITS) region in the ribosomal RNA (rRNA) operon has been accepted as the formal fungal barcode. Despite an increasing number of fungal metabarcoding studies, the amplification efficiency of primers

Impact of metal pollution on fungal diversity and community structures

The impact of metal pollution on plant communities has been studied extensively in the past, but little is known about the effects of metal pollution on fungal communities that occur in metal-polluted soils. Metal-tolerant ecotypes of the ectomycorrhizal fungus Suillus luteus are frequently found in pioneer pine forests in the Campine region in Belgium on metal-polluted soils. We hypothesized that

On modal excitation using capacitive coupling elements and matching network

A resonant characteristic mode (CM) is useful for antenna design if it is properly excited and well matched to the source. In this paper, we consider the feed design for the excitation of the fundamental CM of a rectangular chassis. The tradeoff between the required number of capacitive coupling elements (CCE) and matching elements used for achieving a given antenna bandwidth is studied. The resul

Belowground fungal communities in pioneer Scots pine stands growing on heavy metal polluted and non-polluted soils

The impact of soil metal pollution on plant communities has been studied extensively in the past.However, very little is known about the fungal species that co-occur with these plant communities onmetal polluted soils.We characterized the belowground fungal community in a heavy metal polluted anda non-polluted soil using 454 pyrosequencing. The fungal communities at both study sites were shown toc

Mat, myter och maskiner

Bakom våra mest vardagliga livsmedel ligger en lång och fängslande historia. Varför gav sig pälsjägaren Birdseye ut på Alaskas iskalla vidder, på jakt efter en perfekt fryst ärta? Hur kunde Herbert Felix göra succé med en ketchupfabrik i Skåne – trots att det var omöjligt att odla tomater där? Här får du lära dig varför luft blev den avgörande ingrediensen i glass, oavsett om det upptäcktes av Dji

Det ängsliga matsamhället: Det fina med färdigmaten

Vad är egentligen problemet med industrimaten?Allt mer av det vi stoppar i oss har vid något tillfälle befunnit sig i fabrikernas rostfria ståltankar, transporterats på löpande band, behandlats med kemiskt framtagna tillsatser och förpackats i färgglada förpackningar. Istället för gladlynta kockar eller känsliga mathantverkare är det idag kemister, ingenjörer och industriarbetare som designar, til

Structural variability and niche differentiation in the rhizosphere and endosphere bacterial microbiome of field-grown poplar trees

BACKGROUND: The plant microbiome represents one of the key determinants of plant health and productivity by providing a plethora of functional capacities such as access to low-abundance nutrients, suppression of phytopathogens, and resistance to biotic and/or abiotic stressors. However, a robust understanding of the structural composition of the bacterial microbiome present in different plant micr

Film/Cinema (Sweden)

Sweden succeeded in remaining a non-combatant through the First World War. However, the conflict affected the nation in many ways, for example in terms of film production and film consumption. The Swedish film industry was growing rapidly already before the outbreak of the First World War. The number of cinemas increased every year. It is estimated that there were 700 cinemas in Sweden in 1919, tw