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Breast-cancer-derived cell lines are an important sample source for cancer proteomics and can be classified on the basis of transcriptomic analysis into subgroups corresponding to the molecular subtypes observed in mammary tumors. This study describes a tridimensional fractionation method that allows high sequence coverage and proteome-wide estimation of protein expression levels. This workflow ha
The genus Klyngon Hansson is revised and expanded to include 13 species, 11 of which are newly described: K. albicornis, K. aulacis, K. brasilense, K. copaiferae, K. costalimai, K. gibberum, K. guimaraesi, K. hortense, K. pegosoma, K. petalon, K. serjaniae. The inclusion of the new species necessitates a change of the morphological definition of the genus and diagnostic characters are modified or
Accurate characterization of the astrometric errors in the forthcoming Gaia catalogue is essential for making optimal use of the data. Using small-scale numerical simulations of the astrometric solution, we investigate the expected spatial correlation between the astrometric errors of stars as function of their angular separation. Extrapolating to the full-scale solution for the final Gala catalog
The aging of Western populations is expected to result in increasing occurrence of aortic stenosis (AS), but data are limited. Recent studies have reported declining incidence and mortality for other major heart diseases. We aimed to study temporal trends in the incidence and prognosis for AS in Sweden.
Mobility growth poses considerable challenges to city planners around the world, as it entails problems of congestion, air pollution, and accidents. Many cities have thus sought to increase the share of sustainable transport, and specifically travel by bicycle. However, it appears that measures to foster cycling are often implemented on an ad hoc basis, lacking strategic focus and a more profound
Triple negative (TN) breast cancers make up some 15% of all breast cancers. Approximately 10-15% are mutant for the tumor suppressor, BRCA1. BRCA1 is required for homologous recombination-mediated DNA repair and deficiency results in genomic instability. BRCA1-mutated tumors have a specific pattern of genomic copy number aberrations that can be used to classify tumors as BRCA1-like or non-BRCA1-li
One third of patients with stage T1 urothelial carcinoma (UC) progress to muscle-invasive disease requiring radical surgery. Thus, reliable tools are needed for risk stratification of stage T1 UC.
Critical infrastructure systems must be both robust and resilient in order to ensure the functioning of society. To improve the performance of such systems, we often use risk and vulnerability analysis to find and address system weaknesses. A critical component of such analyses is the ability to accurately determine the negative consequences of various types of failures in the system. Numerous mat
The sensitivity of the process parameters of the Biosphere Energy Transfer HYdrology (BETHY) model to choices of atmospheric concentration network, high frequency terrestrial fluxes, and the choice of flux measurement network is investigated by using a carbon cycle data assimilation system. We use BETHY-generated fluxes as a proxy of flux measurements. Results show that monthly mean or low-frequen
Abstract in UndeterminedMultimodal chromatography is widely used for isolation of proteins because it often results in improved selectivity compared to conventional separation resins. The binding potential and chromatographic behavior of plasmid DNA have here been examined on a Capto Adhere resin. Capto Adhere is a recent multimodal chromatography material allowing molecular recognition between th
Despite temozolomide (TMZ) treatment, the prognosis for patients with glioblastoma multiforme is still dismal. As dose escalation of TMZ is limited by systemic toxicity, intratumoral delivery emerges as an attractive treatment modality, which may sustain cytotoxic drug concentrations intratumorally and induce immunogenic cell death. Both clinical and experimental gliomas have responded to immunoth
• It is well established that individual organisms can acclimate and adapt to temperature to optimize their functioning. However, thermal optimization of ecosystems, as an assemblage of organisms, has not been examined at broad spatial and temporal scales. • Here, we compiled data from 169 globally distributed sites of eddy covariance and quantified the temperature response functions of net ecosys
Globally approximately 60 cases of C1q deficiency have been described with a high prevalence of Systemic Lupus Erythematosus (SLE). So far treatment has been guided by the clinical presentation rather than the underlying C1q deficiency. Recently, it was shown that C1q production can be restored by allogeneic hematopoietic stem cell transplantation. Current literature lacks information on disease p
Re-interventions after endovascular abdominal aortic aneurysm repair (EVAR) are common and therefore a strict imaging follow up protocol is required. The purpose of this study was to evaluate whether cone beam computed tomography (CBCT) can detect intra-operative complications and to compare this with angiography and the 1 month CT follow up (computed tomography angiography [CTA]).
BACKGROUND Neuroendocrine (NE) cells are frequently present in the human prostate and urethra, whereas they are lacking in the other urogenital organs. This study was undertaken as there are only few detailed studies available on the distribution, form and function of NE cells and the structure of excretory ducts of the accessory sex organs in the male rat.
Objective. To describe the prevalence, awareness, and control of hypertension in a Swedish population during the early 2000s to address implications for care and prevention. Design. A cross-sectional population survey. Setting. Primary health care in Skaraborg, a rural part of western Sweden. Subjects. Participants (n = 2816) in a population survey of a random sample of men and women between 30 an
Whereas larger arteries participate in the dampening of blood pressure (BP) oscillations resulting from intermittent ventricular ejection, smaller arteries steadily deliver an adequate supply of blood from the heart to the peripheral organs. Numerous active mechanisms are involved in this process. Cyclic stress acts differently from steady stress, inducing stronger and stiffer material of the vess
Fungal colony size development, often measured as the increase in colony diameter, is used frequently as a parameter for presenting and modelling fungi's biomass growth. Another measure of fungal growth is the heat production rate (thermal power), which represents the metabolic activities of the fungi. In this study, the colony size and the heat production rate were simultaneously measured on a fi
