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Aims: Recent evidence supports non-class cardioprotective effects of metoprolol against neutrophil-mediated ischemia-reperfusion injury during exacerbated inflammation. Whether metoprolol exerts direct anti-inflammatory effect on cardiomyocytes is unknown. Accordingly, we aimed to investigate the direct anti-inflammatory effects of metoprolol in a cellular model of human induced pluripotent stem c

In the present study, digestion pattern of purified bovine κ-casein (κ-CN) variants A, B, E as well as desialylated variant B, using INFOGEST 2.0 in vitro gastrointestinal digestion were investigated using peptidomics. Peptide profiles of the digests were identified and quantified using ion abundancies by liquid chromatography electrospray quadropole time of flight mass spectrometry (LC-ESI/Q-TOF

Materials, when sintered at high temperatures, undergo structural changes on multiple, hierarchical length scales but getting realtime information on these changes is difficult. To address this challenge, we developed a custom-built sample environment that allows us to investigate the structural evolution of materials during sintering using high-energy two-dimensional synchrotron X-ray diffraction

In Fontan patients, a lung deprived of hepatic blood may develop pulmonary arterio-venous malformations (PAVMs) resulting in shunting, reduced pulmonary vascular resistance (PVR) and decreased oxygenation. To provide guidance for corrective invasive interventions, we aimed to non-invasively determine how the hepatic to pulmonary blood flow balance correlates with pulmonary flow, PVR, and with oxyg

Bacterial lipopolysaccharide (LPS) induces rapid protein aggregation in human wound fluid. We aimed to characterize these LPS-induced aggregates and their functional implications using a combination of mass spectrometry analyses, biochemical assays, biological imaging, cell experiments, and animal models. The wound-fluid aggregates encompass diverse protein classes, including sequences from coagul

A hyperspectral field sensor (FloX) was installed in Adventdalen (Svalbard, Norway) in 2019 as part of the Svalbard Integrated Arctic Earth Observing System (SIOS) for monitoring vegetation phenology and Sun-Induced Chlorophyll Fluorescence (SIF) of high-Arctic tundra. This northernmost hyperspectral sensor is located within the footprint of a tower for long-term eddy covariance flux measurements

Inconsistent reporting of outcomes in clinical trials of treatments for whiplash associated disorders (WAD) hinders effective data pooling and conclusions about treatment effectiveness. A multidisciplinary International Steering Committee recently recommended 6 core outcome domains: Physical Functioning, Perceived Recovery, Work and Social Functioning, Psychological Functioning, Quality of Life an

Background: Patients in the forensic mental health services (FMHS) with a mental disorder, a co-occurring substance use disorder (SUD), and high risk of aggressive antisocial behavior (AAB) are sometimes referred to as the ‘triply troubled’. They suffer poor treatment outcomes, high rates of criminal recidivism, and increased risk of drug related mortality. To improve treatment for this heterogene

This chapter considers the creation of the Later Life Audio and Radio Co-operative (LLARC) as an outcome of a participatory action research (PAR) project with a focus on facilitating later life civic participation. Developed in the UK, but with potential to become a global initiative, the LLARC is a collaborative network of older content creators, age-friendly radio stations, third-sector organisa

Context. Gaia Data Release 3 (Gaia DR3) contains the second release of the combined radial velocities. It is based on the spectra collected during the first 34 months of the nominal mission. The longer time baseline and the improvements of the pipeline made it possible to push the processing limit from GRVS= 12 in Gaia DR2 to GRVS= 14 mag. Aims. We describe the new functionalities implemented for

Walking and biking are active transport modes, that may be part of sustainable transport chains, thereby reducing car use. In the scientific literature, they have commonly been investigated separately (e.g. Ewing et al., 2006; Kellstedt et al., 2021), but since pedestrians and cyclists often share the same environments, it makes sense to consider them jointly. This research proposes a conceptual m

OBJECTIVES: We sought to explore 25-year trends of gender disparity in the prevalence of obesity and overweight both in urban and rural areas among Chinese children from 1985 to 2010.METHODS: Data included 1 280 239 children aged 7-18 years enrolled in the Chinese National Survey on Students's Constitution and Health (CNSSCH), which is the largest nationally representative sample of school-aged ch

Limited research has assessed whether sports participation can be linked to decreasing risky sexual behavior among adolescent girls in sub-Saharan Africa. The current study aimed to assess whether participation in a football league that provides sexual and reproductive health and rights lessons before each football match strengthened adolescent Zambian girls’ sexual health knowledge, attitudes, an

148Gd may contribute to around 50% of the dose from inhalation in case of an accident at the European Spallation Source. Methods for its detection have been developed. They rely on biokinetic models predicting activities of the gamma emitters 146Gd (T1/2= 48.3 d) and 153Gd (T1/2= 240.4 d) as tracers in the lungs, urine, and faeces. The optimal choice of model parameters and associated uncertaintie

Barriers to healthcare for men who have sex with men (MSM) in sub-Saharan Africa (SSA) are rooted in stigma and discrimination against MSM fuelled by the criminalization of homosexuality. These barriers are influenced by factors involving MSM and the healthcare workers (HCWs). MSM are uncomfortable disclosing their identities and conceal symptoms of sexually transmitted infections (STIs), especial

Future Internet-of-Things (IoT) systems need to combine heterogeneous IoT components and support weak connectivity. This paper introduces ComPOS, a domain-specific language for composing IoT services into systems. ComPOS is a small language but supports powerful message mediation, using stateful reactions with nested and parallel message sequences and anonymous futures. To deal with weak connectiv

With growing urbanization and increase in energy demand for space heating and cooling in buildings, reliability, security, distribution of energy and its efficient end use is of utmost importance particularly when emissions from energy use and indoor thermal comfort of the end users isof question. Numerous solutions have been put forth in the field of effective distribution of thermal energy to me