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Krüppel-like factors (KLFs) are transcription factors with important roles in tissue homeostasis. KLF4 possesses antithrombotic and anti-inflammatory properties. In this issue, Estrada et al. show that endothelial KLF4 prevents complement deposition in glomeruli and in its absence the cell-bound complement regulator CD55 was reduced. The study included endothelial-specific KLF4 knockdown mice that

Recent technological advances have facilitated and diversified the options available for the diagnosis of cardiac arrhythmias. Ranging from simple resting or exercise electrocardiograms to more sophisticated and expensive smartphones and implantable cardiac monitors. These tests and devices may be used for varying periods of time depending on symptom frequency. The choice of the most appropriate h

Materials with bimodal grain size distributions have an attractive combination of strength and ductility. Harmonic structure materials are a category of bimodal-structure materials with a specific microstructure design. The deformation mechanisms of such novel materials during the early stages of deformation are not well understood. Thus, we deformed nickel with harmonic structure in tension until

Harmonic-structure (HS) design is one of the most efficient in the family of architected gradient-structure materials recently attracting increasing attention in global material science community due to leading structural performance characteristics. This work studies in situ the mechanics of plastic deformation in HS materials on the example of commercially pure nickel (Ni) during uniaxial tensil

This paper investigates the regulation of publicly organized early childhood education and care (ECEC) in Denmark and Sweden, through the regulatory welfare state (RWS) framework. The analysis focuses on how alterations in funding and quality of care are shaped by governmental and nongovernmental actors at national and local levels of government. Through focused structured analysis, we examine howThis paper investigates the regulation of publicly organized early childhood education and care (ECEC) in Denmark and Sweden, through the regulatory welfare state (RWS) framework. The analysis focuses on how alterations in funding and quality of care are shaped by governmental and nongovernmental actors at national and local levels of government. Through focused structured analysis, we examine how

How neurons can maintain cellular identity over an entire life span remains largely unknown. Here, we show that maintenance of identity in differentiated dopaminergic and serotonergic neurons is critically reliant on the Polycomb repressive complex 2 (PRC2). Deletion of the obligate PRC2 component, Eed, in these neurons resulted in global loss of H3K27me3, followed by a gradual activation of genes

The ordinary cities are the dominant sites of urban living, theorization and debates. This presentation centrally situates the dimension of urban density to unfold a unique, however, ordinary aspect of urban contention. It situates the state’s formal housing paradigm for the urban poor as the case of theoretical intervention from an ongoing research project. It aims to broaden the understanding of

As a state where the ruling communist party operates in a central planning mode, the policies of the ruling party and central government exert a great influence on national affairs with a long historical tradition in China, which can be even more obviously illustrated in the issues of climate change. But on the other hand, there is still no specific national climate legislation in China, which is

This debate concerns the relevance and suitability of the ‘Chinese model’ of environmental governance for the rest of the world as other countries grapple with how to govern climate change. Tianbao Qin and Meng Zhang argue that heavily directed and enforced environmental regulation, as manifested in China, is an efficient and effective form of governance for bringing about the necessary structural

Is China a superhero intent on saving the world economy or a monster focused on damaging the global environment? As a developing country with the largest population in the world, China has wrought a stunning miracle of economic development. However, this rapid economic growth, like a double-edged sword, has given rise to severe environmental problems, such as climate change, water pollution and re

Nowadays China is increasingly facing strong international pressures to reduce carbon emissions, standing at the cross-road of climate change issues: how to fulfill the emission reduction goal without undermining and blocking its ambitions on sustainable economic development. Facing this situation, carbon capture and storage（CCS）can be a new weapon for China to win the battle of climate change mit

The Chinese government is acutely aware of the problem of climate change. In the crucial crossroads, carbon emissions trading scheme (ETS), a kind of market-based instruments based on cap-and-trade, has become the new hope of carbon governance and the most important measure adopted to mitigate climate change. Based on the description and analysis on the ongoing process of pilot ETS in China and it

PurposeTo analyse structural characteristics of malformations of cortical development (MCD) at 7T and 3T MRI.MethodsTwenty-five patients were examined with a 7T MRI-scanner in addition to 3T examinations performed for epilepsy evaluation. 7T sequences included a 3D-T1-weighted (T1w) MPRAGE, 3D-T2w FLAIR, and heavily T2w axial and coronal high-resolution (0.5×0.5×0.75-1.0 mm3) 2D-TSE sequences. Ima