The normal-like molecular subtype of breast cancer has not been well characterized and is currently not included in the clinically approved PAM50 molecular subtype classification. Tumors classified as normallike display high expression of basal epithelial genes and low expression of luminal epithelial genes, but also high expression of genes expressed by non-epithelial cell types including adipocy

PAM50 gene expression subtypes represent a cornerstone in the molecular classification of breast cancer and are included in risk prediction models to guide therapy. We aimed to illustrate the impact of included genes and biological processes on subtyping while considering a tumor’s underlying clinical subgroup defined by ER, PR, and HER2 status. To do this we used a populationrepresentative and cl

Corded Ware is one of the main archaeological phenomena of the third millennium before the common era (BCE), with a wide geographic spread across much of central and northeastern Europe, from Denmark, the Rhineland, and Switzerland in the west to the Baltic and Western Russia in the east, and broadly restricted to the temperate, continental zones north of the Alps, the Carpathians, and the steppe/

BACKGROUND: Traumatic brain injury (TBI) constitutes a global epidemic. Overall outcome is poor, with mortality ranging from 10 to 70% and significant long-term morbidity. Several experimental reports have claimed effect on traumatic edema, but no clinical trials have shown effect on edema or outcome. Antisecretory factor, an endogenous protein, is commercially available as Salovum®, which is clas

This paper investigates the apparent near-optionality of the perfect auxiliary ha (‘have’) in Swedish. Restrictions on the near-optionality of ha-omission are typically recognized in the previous literature as lexical or structural. The paper scrutinizes the viability of these restrictions by means of corpus data. Most of these restrictions are shown not to hold. Instead, the paper defends the vie

The article discusses strategies adopted in Jonas Poher Rasmussen’s feature-length animated documentary Flee (2021) for crossing the cultural andemotional distance between audiences and the refugee protagonist Amin. Focusis on a central scene in which a group of Afghans sailing across the Baltic Seain the early 1990s encounters a cruise ship from Norway, the crew of whichreports the refugees to th

The Baltic Sea has effectively separated the Scandinavian and Eastern European countries, especially in the period when this body of water constituted a part of the Iron Curtain and functioned for Scandinavians as an imaginary protective moat. From the East-Central European perspective, the Baltic Sea offered a hope of escape to freedom, encapsulated in the cinematic trope of the sea as a ‘blue bo

The paper outlines a comprehensive set of recommendations, advocating for a systems thinking approach and acknowledging the importance of engaging with the entire food system.Embracing protein diversification fosters innovation, has the potential to create substantial economic opportunities and position EU Member States at the forefront of rapidly evolving sectors spanning and integrating biotechn

BACKGROUND: Sushi domain-containing protein 4 (SUSD4) is a recently discovered protein with unknown cellular functions. We previously revealed that SUSD4 can act as complement inhibitor and as a potential tumor suppressor.METHODS: In a syngeneic mouse model of breast cancer, tumors expressing SUSD4 had a smaller volume compared with the corresponding mock control tumors. Additionally, data from th

Open science aims to improve research accessibility, replicability, and consequently its quality. Empirical software engineering entails both data and artifacts, which may be shared more or less openly, to support transparency. However, the trade-offs involved in balancing the openness against integrity and secrecy concerns need methodological guidance. Aim. We aim to derive such advice, based on

Kapitlet diskuterar vilken roll systemintermediärer spelar för att främja innovation i lokala ekosystem. Fallet som studeras är hur Lunds kommun tillsammans med andra aktörer har valt att bygga upp en särskild organisation, Future by Lund, för att tillsammans driva frågor som rör samhällsutveckling. Utgångspunkten är att dagens innovationspolitiska insatser i stor utsträckning fokuserar på samhäll

Radionuclides released and discharged into the environment from nuclear and other radiation-related facilities, such as the European Spallation Source (ESS), may accumulate in aquatic bottom sediments. Sediments should therefore, as recommended by the IAEA, be monitored regularly. This report describes the setting up of a methodology for zero-point assessments of the radiation levels in sediments