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Purpose: To examine associations between the APOE-ε2 and APOE-ε4 alleles and core Alzheimer’s disease (AD) pathological hallmarks as measured by amyloid-β (Aβ) and tau PET in older individuals without dementia. Methods: We analyzed data from 462 ADNI participants without dementia who underwent Aβ ([18F]florbetapir or [18F]florbetaben) and tau ([18F]flortaucipir) PET, structural MRI, and cognitive

En bön som kallas Heliga Birgittas har blivit populär bland pilgrimer: "Herre, visa mig din väg och gör mig villig att vandra den". Den är inspirerad av Birgittas uppenbarelser, men är inte ett ordagrant citat. Den är hämtad ur en längre bön av kyrkoherden Sam Stadener, ihopredigerad av Birgittacitat som Emilia Fogelklou tillhandahållit. Denna bön publicerades i Den svenska psalmbokens bönbok 1921

The existing information supports the use of this material as described in this safety assessment. 4,5,6,7,8,9,10,11,12,13-Decahydrocyclododecaoxazole was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that 4,5,6,7,8,9,10,11,12,13-decahydrocyclododecaoxa

Background: The HYPO-RT-PC trial compared conventionally fractionated radiotherapy with ultra-hypofractionated radiotherapy in patients with localised prostate cancer. Ultra-hypofractionation was non-inferior to conventional fractionation regarding 5-year failure-free survival and toxicity. We aimed to assess whether patient-reported quality of life (QOL) differs between conventional fractionation

Artikeln påminner svensk praktisk teologi om dess historiskt givna identitet samt visar att denna identitet härleds ur ett bestämt encyklopediskt sammanhang. Utgångspunkten för den encyklopediska bestämningen är att akademisk teologi är en i Schleiermachers mening positiv vetenskap, vars uppgift är att främja kyrka och kristendom. I denna positiva vetenskap har den praktiska teologin rollen av proThe purpose of this article is to remind Practical Theology in Sweden of its historically given identity and to show that this identity derives from a welldefined encyclopedic context. The point of departure is that theology is a positive science, in the sense used by Friedrich Schleiermacher: a science directed towards a specific goal, which in theology's case is the wellinformed government of th

The existing information supports the use of this material as described in this safety assessment. Glyceryl monooleate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that glyceryl monooleate is not genotoxic. Data on glyceryl monooleate provide a cal

Epicardial adipose tissue has a paracrine effect, enhancing coronary artery atherosclerotic plaque development. This study evaluated epicardial fat volume (EFV), adipokines, coronary atherosclerosis, and adverse cardiovascular events in a cohort of asymptomatic patients with type 2 diabetes mellitus (T2DM). Epicardial fat volume was calculated using data from computed tomography coronary angiogram

Background & Aims: Mutations in the HFE gene can lead to hereditary haemochromatosis (HH) and have been suggested to increase the risk of extra-hepatic diseases, especially breast and colorectal cancer. Here we investigated long-term outcomes of Swedish patients with HFE mutations. Methods: We identified 3645 patients with a homozygous p.C282Y (62%) or a compound heterozygous p.C282Y/p.H63D (3

The development of tau-PET allows paired helical filament tau pathology to be visualized in vivo. Increased knowledge about conditions affecting the rate of tau accumulation could guide the development of therapies halting the progression of Alzheimer's disease. However, the factors modifying the rate of tau accumulation over time in Alzheimer's disease are still largely unknown. Large-scale longi

Neurofilament light (NfL) is a marker of neuroaxonal injury, a prominent feature of Alzheimer's disease. It remains uncertain, however, how it relates to amyloid and tau pathology or neurodegeneration across the Alzheimer's disease continuum. The aim of this study was to investigate how plasma NfL relates to amyloid and tau PET and MRI measures of brain atrophy in participants with and without cog

Översättning av antik källtext, Afthonios progymnasmata från klassisk grekiska till svenska, 32 sidor. Inledning med historisk kontext, tidigare översättningar på andra språk, översättningsprinciper och forskningsöversikt, 40 sidor. Kommentar av översättningen, förklaring av retorisk teori, grekisk mytologi och historiska bakgrund, 120 sidor. Första upplagan från 2002 slutsåld. Ny andra upplaga i

Responding to today's often transboundary emergencies, frequently characterized by unclear root causes and indistinct responsibilities as well as multiple actors, will require that responding actors come together to meet societal needs and solve problems arising in relation to those needs. In collective problem solving, representing the problem is crucial, especially in emergency situations, where

Vi lever i en apokalyptisk tid. Apokalyptisk argumentation till stor del outforskad. Artikeln presenterar en analysmodell i tre steg: upplevd ondska, tidens tecken och tillförlitlig auktoritet, inspirerad av Stephen O'Leary. Artikeln innehåller två analysexempel: USA:s förre president Donald Trump och den Islamiska staten. Båda bygger sin argumentation på en apokalyptisk världsbild.Our time is an apocalyptic time, but the argumentation in this apocalyptic time has hardly been studied by scholars of argumentation. This article shows how both Donald Trump and the jihadist warriors of ISIS appeal to an apocalyptic worldview in their argumentation. The three topos of evil, time and authority from Stephen O’Leary’s Arguing the Apocalypse are used in the analysis. Both Trump suppo