New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed

The paper deals mainly with two problems in the epistemology of Frank Plumpton Ramsey. One concerns his account of knowledge, the other his fallibilism. I argue that Ramsey failed to make room for the social aspect of knowledge and, furthermore, that he did not separate the fallibility of our view from its corrigibility. My positive proposal is to combine social reliabilism and corrigibilism with

Popular Abstract in Swedish Avhandlingen behandlar nätverksmekanisk modellering av mekaniska egenskaper hos cellulosafiberfluff. Cellulosafiberfluff består av fibrer utvunna från trä, och används bl a i blöjor och isoleringsmaterial. En nätverksmekanisk modell är en typ av mikro-mekanisk modell. Principen för denna typ av modell är att man gör antaganden för hur materialet fungerar på mikro-nivåA network mechanics model for cellulose fibre fluff is proposed. 2D and 3D versions of the model have been implemented and the influence of various micro-level parameters on the global mechanical performance has been determined by means of computer simulations. Model networks composed of bonded fibres of arbitrary distribution in length, curvature, cross-section, stiffness and strength were inves

The molecular structure of Na,K-ATPase was determined by electron crystallography from two-dimensional crystals induced in purified membranes isolated from the outer medulla of pig kidney. The P2 type unit cell contains two protomers in the E2 conformation, each of them with a size of 65 x 75 x 150 Å3. The , ß, and subunits in the membrane crystals were demonstrated in the crystals with Western bl

Kunskapöversikt över forskningsläget kring hållbar stadsutveckling från samhällsvetenskapliga perspektiv.

Low-molecular weight aromatic compounds were extracted from aqueous samples in a packed high-pressure stainless steel column with supercritical carbon dioxide. A countercurrent flow approach was utilised to remove several phenolic and two non-phenolic compounds with similar aromatic structures directly from aqueous standard solutions as well as a real sample (a lignocellulose dilute-acid hydrolysa

Accuracy of 131I tumor quantification after radioimmunotherapy (RIT) was investigated for SPECT imaging with an ultra-high-energy (UHE) collimator designed for imaging 511-keV photons. METHODS: First, measurements and Monte Carlo simulations were carried out to compare the UHE collimator with a conventionally used, high-energy collimator. On the basis of this comparison, the UHE collimator was sel

Assessing the results of modern cystic fibrosis (CF)-care and estimating the future population and its demography is important to evaluate the treatment regimens and to calculate the future needs of health-care resources.This paper updates previous incidence calculations. It assesses the results of modern CF-care in terms of survival and changing demography in Sweden. The incidence of CF in Sweden

Apoptosis is essential to eliminate secretory epithelial cells during the involution of the mammary gland. The environmental regulation of this process is however, poorly understood. This study tested the effect of HAMLET (human alpha-lactalbumin made lethal to tumor cells) on mammary cells. Plastic pellets containing HAMLET were implanted into the fourth inguinal mammary gland of lactating mice f

We simulate two-dimensional lattices of pulse-coupled oscillators with random natural frequencies, resembling pacemaker cells in the heart. As coupling increases, this system seems to undergo two phase transitions in the thermodynamic limit. First, the largest cluster of frequency entrained oscillators becomes macroscopic. Second, all oscillators frequency entrain, except possibly some isolated on

Popular Abstract in Swedish Nervskador som drabbar händerna orsakar stora problem både för den drabbade i form av försämrad handfunktion och för samhället i form av kostnader på grund av långvarig sjukskrivning. Trots mikrokirurgisk nervreparations teknik med användande av speciella instrument och mikroskop får vuxna patienter ofta bestående besvär med känselbortfall, muskelsvaghet och smärta. AvThe aim of this thesis was to investigate the effects of cortical reorganisational changes following experimental deafferentation and peripheral nerve injury and apply the concept of brain plasticity to enhance sensory re-education following peripheral nerve injury and repair in the hand. In the first two papers the effects on hand function of contralateral deafferentation was investigated. Tourn

Samlingsrecension av BFI-monografier om skräck- och science fiction-film

The study of Hox clusters and genes provides insights into the evolution of genomic regulation of development. Derived ray-finned fishes (Actinopterygii, Teleostei) such as zebrafish and pufferfish possess duplicated Hox clusters that have undergone considerable sequence evolution. Whether these changes are associated with the duplication(s) that produced extra Hox clusters is unresolved because c

OBJECTIVE: To characterize the clinical phenotype, with emphasis on electrophysiology and blood flow measurements, of a family with dominant optic nerve atrophy and an identified mutation in the OPA1 gene. METHODS: Seven family members were examined. Ophthalmological evaluation included testing of visual acuity, ophthalmolscopy, kinetic perimetry, color vision testing, full-field electroretinograp