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Improvements in metabolite-profiling techniques are providing increased breadth of coverage of the human metabolome and may highlight biomarkers and pathways in common diseases such as diabetes. Using a metabolomics platform that analyzes intermediary organic acids, purines, pyrimidines, and other compounds, we performed a nested case-control study of 188 individuals who developed diabetes and 188
The aim was to confirm a previously defined prognostic index, combining a proliferation marker, histological grade, and estrogen receptor (ER) in different subsets of primary N0/N1 chemo-naïve breast cancer patients.
Film and history, interdisciplinarity. Introduction to a special feature issue
Background: Lentiviral vectors hold great promise as gene transfer vectors in gene therapeutic settings. However, problems related to the risk of insertional mutagenesis, transgene silencing and positional effects have stalled the use of such vectors in the clinic. Chromatin insulators are boundary elements that can prevent enhancer-promoter interactions, if placed between these elements, and prot
While the precise relationship between the Milky Way disk and the symmetry planes of the dark matter halo remains somewhat uncertain, a time-varying disk orientation with respect to an inertial reference frame seems probable. Hierarchical structure formation models predict that the dark matter halo is triaxial and tumbles with a characteristic rate of similar to 2 rad H-0(-1) (similar to 30 mu as
Measurements of the adiabatic laminar burning velocities of n-heptane, iso-octane, ethanol and their binary and tertiary mixtures are reported. Non-stretched flames were stabilized on a perforated plate burner at 1 atm. The Heat Flux method was used to determine burning velocities under conditions when the net heat loss from the flame to the burner is zero. Initial temperatures of the gas mixtures
The topic of this thesis is subjectless clauses in Old Swedish (1225–1526). The thesis focuses on referential subjects, and addresses the problem of why the possibilities to leave out such subjects have been reduced during the history of Swedish. The dissertation consists of three main parts, divided into eight chapters. In the first part, chapters 1–3, the aims are presented and a theoretical bac
A BFKL dipole model, and its event generator DIPSY, developed for pp collisions is extended to initial states of heavy ion collisions. All tuning is made for gamma*p and pp inclusive and minimum bias data, leaving the extension to heavy ions model independent. Eccentricities are calculated and compared to other common inital state models.
Context. In many plasmas, long-lived metastable atomic levels are depopulated by collisions (quenched) before they decay radiatively. In low-density regions, however, the low collision rate may allow depopulation by electric dipole (E1) forbidden radiative transitions, so-called forbidden lines (mainly M1 and E2 transitions). If the atomic transition data are known, these lines are indicators of p
The present thesis investigates, analyses and critically discusses the manner in which children with special needs are categorised in the Swedish preschool. The emergence of the category and its construction depends on a number of “truths” concerning children, related to historical and cultural processes in society. A main focus of the thesis is to investigate how legitimacy is established for the
A search for a heavy Standard Model Higgs boson decaying via H -> ZZ -> l(+)l(-)q (q) over bar, where l = e or mu, is presented. The search uses a data set of pp collisions at root s = 7 TeV, corresponding to an integrated luminosity of 4.7 fb(-1) collected in 2011 by the ATLAS detector at the CERN LHC. No significant excess of events above the estimated background is found. Upper limits at 95% co
Background: beta-Microseminoprotein (MSP) is one of the three most abundantly secreted proteins of the prostate and has been suggested as a biomarker for prostate cancer risk. A common variant, rs10993994, in the 5' region of the gene that encodes MSP (MSMB) has recently been identified as a risk factor for prostate cancer. Methods: We examined the association between rs10993994 genotype and MSP l
The article concerns Roman Britain.
We test if innovations in investor risk aversion are a priced factor in the stock market. Time series tests show that the new factor partly explains the strong momentum effect in stock returns. Furthermore, using 25 portfolios sorted on book-to-market and size as test assets, our new factor together with the market factor explains 64% of the variation in average returns compared to 60% for the Fam
This thesis analyses fluid management services (FMS) in metalworking industry and determines environmental and economic outcomes of FMS as compared to traditional, in-house, fluid management. Fluid management services, or as it is often called chemical management services (CMS), mean that the suppliers of chemicals are also involved in managing and maintaining the fluids in the use phase. Usually
The electronic structure of strongly correlated systems is usually calculated by using an effective model Hamiltonian with a small number of states and an effective on-site interaction. The mode, however, neglects the frequency dependence of the interaction, which emerges as a result of dynamical screening processes not included in the model. The self-energy calculated in this kind of model within
This paper describes and illustrates how a network picture methodology can create understandings of external parties in mergers and acquisitions (M&As). Recent studies have brought attention to the limited use of qualitative research methods and the overlooked marketing perspective in M&A studies. Network pictures refer to how individual actors in companies perceive their company's busines
