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Objective: The aim of this research is to identify germline genetic variants that predispose to uveal melanoma (UM) using data from nine studies involving 5839 individuals with UM (3853 novel) and 349,863 healthy controls. Methods: Five novel UM genome-wide association studies (GWAS) were performed and included for meta-analysis with four previously published UM GWAS. A fixed-effects inverse-varia
While prostate cancer (PrCa) is highly heritable, the genes associated with PrCa survival after diagnosis remain poorly understood. We aimed to identify genes associated with PrCa-specific survival through transcriptome-wide association studies (TWAS) using genetic predictors of gene expression in the prostate. We used the Transcriptome-Integrated Genetic Association Resource (TIGAR) to train expr
AIMS: To study the associations of dietary intake of A and E vitamins, as well as plasma retinols, carotenoids, and tocopherols in relation to development of islet autoimmunity and progression to T1D.MATERIALS AND METHODS: The Environmental Determinants of Diabetes in the Young (TEDDY) Study followed 7659 newborns with genetic susceptibility to T1D for 6 years in the USA, Finland, Germany, and Swe
BACKGROUND/OBJECTIVES: Vitamin K dependent proteins are involved in numerous biological processes, including coagulation, cancer development and inflammation, but their profile and functions in many patient groups and conditions are still unknown. The aim of this study was to describe vitamin K dependent proteins in patients undergoing head and neck free flap surgery, with the hypothesis that thes
ContextIn recent decades, breastfeeding rates and the duration of breastfeeding among American womenhave been increasing. A consequence of longer breastfeeding, however, is that it is more likely tooverlap with subsequent pregnancies, and the implications of this arrangement for pregnancyoutcomes is not well understood.MethodsCox proportional hazards models were used to investigate the association
The aggregation of amyloid proteins into fibrillar and oligomeric aggregates is linked to a number of neurodegenerative diseases. While the disease onset remains elusive in many cases, an understanding of the driving forces for the aggregation may help finding possible causes. While effects on amyloid formation kinetics are more commonly studied, gaining insights into these driving forces require
Quest2ROS2 is an open-source ROS2 framework for bi-manual teleoperation designed to scale robot data collection. Extending Quest2ROS, it overcomes workspace limitations via relative motion-based control, calculating robot movement from VR controller pose changes to enable intuitive, pose-independent operation. The framework integrates essential usability and safety features, including real-time RV
Abstract – Introduction: – Severe symptoms and disability may remain after upper and lower limb nerve injuries with an additional risk of persistent pain and consumption of pain medication.Objectives: – To examine whether upper and lower limb nerve injuries, potentially causes of pain, are associated with risk of using pain medication.Methods: – Drug use at an individual level was analysed in a la
Objectives To assess the performance of the ALL IN TRIPLEX rapid antigen-based test for SARS-CoV-2, influenza A, influenza B, and respiratory syncytial virus. We focus on the potential of the test to be used in acute clinical settings as a marker of infectiousness, by determining the sensitivity at different real-time PCR cycle threshold (Ct) levels, as well as the quantity of absorbed viral RNA n
AimTo characterize the intracanal microbiota and identify key microbial taxa and functional pathways associated with regenerative endodontic treatment (RET) outcomes.MethodologyIn this observational cohort study, 196 samples were collected at five time points from external tooth surfaces (T1, T4) and root canals (T2, T3, T5). The V3–V4 hypervariable region of 16S rRNA gene was amplified and sequen
Freshwater blooms of the microcystin-producing (toxigenic) cyanobacterium Microcystis may cause severe damage to human health and the environment. However, toxigenic and non-toxigenic strains co-exist within single blooms, and microcystin concentration in the water varies throughout the season. We hypothesized that strains that produce and do not produce microcystins represent different genotypes.
Understanding and manipulating micelle morphology is key to exploiting surfactants in applications from templating mesoporous materials to formulation of creams and lipid particles for drug delivery. The drive to replace toxic organic solvents in extractions, syntheses and materials processing as well as the shift toward use of natural components in formulations has led to increasing demand for su
Sundaland, a subcontinent situated in the Indo-Malay Archipelago, is characterized by a dynamic climatic, geological, and geographical history and a correspondingly diverse biota. The distribution of this biota follows complex biogeographical patterns, with high levels of local endemism and frequent instances of hidden diversity—greater genetic differentiation than expected based on phenotype. Bio
This letter addresses the robustness of a prescribed-time observer for a class of nonlinear systems in the presence of disturbances and unmodeled dynamics. It is proven and demonstrated through simulations that the proposed observer completely rejects the effects of large bounded disturbances and unmodeled dynamics, enabling accurate estimation of both the states and the disturbances. Furthermore,
Recovery from significant mental health issues is a multidimensional process, which can be considered from a range of perspectives. However, mental health services have traditionally been limited to addressing custodial and clinical aspects of recovery. This narrow view of recovery prioritizes physical safety and security while addressing symptoms via medical and psychological treatments. People l
Migraine treatments that target calcitonin gene-related peptide (CGRP) are widely used, but questions remain regarding their mechanisms and sites of action. Re-examination of the effects of CGRP in the trigeminovascular system has now refined our understanding of nociceptive CGRP signalling and underscores the importance of early therapeutic intervention.
Background Body dysmorphic disorder (BDD) is a debilitating and understudied psychiatric condition of largely unknown etiology. Emerging evidence suggests that BDD may be a familial and heritable disorder, but family studies of diagnosed individuals and their biological relatives are yet to be conducted. Methods We identified 4,857,049 individuals born in Sweden between 1960 and 2008 with informat
Bacterial infection and hemorrhage remain significant clinical challenges for chronic wounds, despite advancements in antimicrobial strategies and materials. Herein, 980 nm-laser-responsive photothermal conjugated polymers (CPs) are combined with chitosan-based cryogels (CP@Gel) to achieve rapid hemostasis and efficient anti-infectious performance. CP nanoparticles (CP NPs) were prepared by nanopr
Objective This study attempted to quantify the bias expected due to partly interval-censored (IC) outcomes in the estimated association between hydroxychloroquine (HCQ) taper/cessation and time to disease flare among individuals with systemic lupus erythematosus (SLE). Methods Using data-driven simulations, we estimated bias expected due to IC using real-world data from the Systemic Lupus Internat
