Experimental studies have established that the sulfated glycosaminoglycans heparan sulfate and chondroitin sulfate act as co-receptors of cytokines and growth factors that drive the malignant cell phenotype and the remodelling of the surrounding tumor stroma. However, the clinical relevance of these studies remains ill-defined. The present study investigates the significance of chondroitin sulfate

The article studies the character of general readers’ reviews on the internet bookstore Amazon; what is called private criticism. Patterns, common features, and contradictions are explored, and the social position and meaning of new forms of readers’ expressions is discussed. One part of the thesis is that the freedom of speech in the public sphere has given readers new and different opportunities

Cardiac troponins are biomarkers of myocardial injury and serve both diagnostic and prognostic purposes. Even mild elevations represent subclinical myocardial damage in the general population. The objective of this study was to investigate the relationship between glucometabolic status and cardiac troponin T in middle-aged or older apparently healthy subjects.

I argue that the human sciences (i.e. humanities, social- and behavioural sciences) should not try to imitate the methodology of the natural sciences. The human sciences study meaningful phenomena whose nature is decisively different from the merely physical phenomena studied by the natural sciences, and whose study therefore require different methods; meaningful phenomena do not obviously obey na

The amplified spontaneous emission spectra of quantum-cascade laser structures is computed with a Keldysh Green's functions theory. We show that the emission spectra are sharpened in comparison to gain spectra due to wave guide propagation. In addition the different dependence on level occupation causes moderate differences between gain and emission peak positions. Our fit-parameter-free theory is

Kulturartikel om vampyren på film med anledning av bioaktuella filmer som Blade och Vampyrer (John Carpenter's Vampire's).

Non-therapeutic research on children raises ethical concerns. Such research is not only conducted on individuals who are incapable of providing informed consent. It also typically involves some degree of risk or discomfort, without prospects of medically benefiting the participating children. Therefore, these children seem to be instrumentalized. Some ethicists, however, have tried to sidestep thi

BACKGROUND: Childhood leukemia is characterized by the presence of balanced chromosomal translocations or by other structural or numerical chromosomal changes. It is well know that leukemias with specific molecular abnormalities display profoundly different global gene expression profiles. However, it is largely unknown whether such subtype-specific leukemic signatures are unique or if they are ac

Abstract not available

Automated classification of ECG patterns is facilitated by careful selection of waveform features. This paper presents a method for evaluating the properties of features that describe the shape of a QRS complex. By examining the distances in the feature space for a class of nearly similar complexes, shape transitions which are poorly described by the feature under investigation can be readily iden

Objective. Patients with inflammatory bowel disease (IBD) often have low iron stores or anaemia. There is controversy about whether iron should be supplemented orally or intravenously (i.v.). The purpose of this study was to investigate whether treatment with intravenous iron is superior to treatment with oral iron. The primary end-points were response and remaining anaemia at the end of treatment

Segmental defects of long bones are notoriously difficult to treat. This study evaluates eight cases in which the Masquelet technique of induced membranes was used. The primary purpose was to assess the results compared to other types of bone reconstruction and share our tips and tricks to improve the outcome.