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AZD5423 is a selective glucocorticosteroid receptor modulator developed for the inhaled use in asthma and COPD. This study reports the initial, first-in-man, single and repeat dose-escalating studies in healthy male individuals, including one cohort of male Japanese individuals. Inhaled, nebulized AZD5423 was safe and well tolerated up to and including the highest doses tested for up to 2 weeks of
In this paper, we analyze how to continuously adjust the speed in a supply chain with stochastic demand. For each unit (e.g., truckload, shipping container) in the chain, one must decide at which speed it should be moved downstream, given the state of the system, to minimize total supply chain costs. We decompose the problem into a set of one-dimensional subproblems that can be easily solved and c
Current research investigates automation feedback design compared with a potential design solution that may increase pilot’s situation awareness of the Flight Mode Annunciators (FMAs) to reduce pilot workload and improve human-automation coordination. The research tools include an Eye Tracker and B747 flight simulator. This research evaluated two types of FMAs; a proposed glareshield mounted FMAs
Methanol is today considered a viable green fuel for combustion engines because of its low soot emissions and the possibility of it being produced in a CO2-neutral manner. Methanol as a fuel for combustion engines have attracted interest throughout history and much research was conducted during the oil crisis in the seventies. In the beginning of the eighties the oil prices began to decrease and i
The printed circuit boards basis of electronic equipment have seen a rapid growth in recent years and played a significant role in modern life. Nowadays, the fact that electronic devices upgrade quickly necessitates a proper management of waste printed circuit boards. Non-destructive desoldering of waste printed circuit boards becomes the first and the most crucial step towards recycling electroni
We obtain a sharp norm estimate for Hankel operators with anti-analytic symbol for weighted Bergman spaces. For the classical Bergman space, the estimate improves the corresponding classical Putnam inequality for commutators of Toeplitz operators with analytic symbol by a factor of 1/2, answering a recent conjecture by Bell, Ferguson and Lundberg. As an application, this yields a new proof of the
X-ray absorption spectroscopy (XAS) includes well-established methods to study the local structure around the absorbing element - extended X-ray absorption fine structure (EXAFS), and the effective oxidation number or to quantitatively determine the speciation of an element in a complex matrix - X-ray absorption near-edge structure (XANES). The increased brilliance and intensities available at the
In this paper, we prove existence and uniqueness of matings of a large class of renormalizable cubic polynomials with one fixed critical point and the other cubic polynomial having two fixed critical points. The resulting mating is a Newton map. Our result is the first part toward a conjecture by L. Tan, stating that all (cubic) Newton maps can be described as matings or captures.
Our aim was to study the association between country of birth and incidence of gout in different immigrant groups in Sweden. The study population included the whole population of Sweden. Gout was defined as having at least one registered diagnosis in the National Patient Register. The association between incidence of gout and country of birth was assessed by Cox regression, with hazard ratios (HRs
The new compounds and potential ligands 2-(3,5-di-tert-butyl-1H-pyrazol-1-yl)ethyldiphenlyphosphinite (L1), 2-(3,5-di-tert-butyl-1H-pyrazol-1-yl)ethyldiethylphosphite (L2), 2-(3,5-di-tert-butyl-1H-pyrazol-1-yl)ethyl-diethylphosphite (L3) and 2-(3,5-diphenyl-1H-pyrazol-1-yl)ethyldiethylphosphite (L4) were prepared from the reaction of (3,5-(disubstituted)pyrazol-1H-yl)ethanol and the appropriate ph
Objectives To examine predictors of work ability gain and loss after anti-tumour necrosis factor (TNF) start, respectively, in working-age patients with rheumatoid arthritis (RA) with a special focus on disease duration. Methods Patients with RA, aged 19-62 years, starting their first TNF inhibitor 2006-2009 with full work ability (0 sick leave/disability pension days during 3 months before bio-st
A background on the Europan Spallation Source is given, and our work on three control problems important for the design of its linear accelerator are presented.
Background The liver-first strategy signifies resection of liver metastases before the primary colorectal cancer. The aim of the present study was to compare failure to complete intended treatment and survival in liver-first and classical strategies. Methods All patients with colorectal cancer and synchronous liver metastases planned for sequential radical surgery in a single institution between 2
The UN High Level Panel has called for a data revolution. The world’s population should be counted, measured, weighed, and evaluated. This information should be collected, compiled, aggregated, and presented in such a form that it can usefully inform policy-makers and citizens in aggregated forms, and disaggregated according to region, village, gender, and population group. It is tempting to think
