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The incretin hormone glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-stimulated insulin secretion, and affects β-cell turnover. This study aimed at evaluating if some of the beneficial effects of GIP on glucose homeostasis can be explained by modulation of islet blood flow. Anesthetized Sprague–Dawley rats were infused intravenously with different doses of GIP (10, 20, or 60
Metalloenzymes are proteins that contain one or more metal ions bound to protein. They constitute about one-third of all enzymes known so far and they often perform hard chemical reactions involving small substrates, like H2 and N2. In our research, we focus on those metal ions that are located in the active sites and perform redox reactions, i.e. involving electron transfer. Why enzymes?Metalloenzymes catalyse a wide variety of reactions in nature. In the thesis, I have studied the reaction mechanism of three metalloenzymes, viz. [NiFe] hydrogenase (H2ase), dimethyl sulfoxide reductase (DMSOR) and formate dehydrogenase (FDH), by theoretical methods, namely quantum mechanics (QM), combined quantum mechanical and molecular mechanics (QM/MM), as well as QM/MM thermodynamic cycle per
For over 30 years GIS has been a major theme in archaeology, leading scholars to debate the way geo-spatial platforms can contribute to a better understanding of the ancient landscape and a more thorough interpretation of the archaeological record. Recently, the introduction of more advanced software and hardware solutions have made it possible to use GIS for visualizing and analysing even geometr
This dissertation investigates the causes of economic fluctuations in the United Kingdom between the Industrial Revolution and the Second World War. The first part of the dissertation studies the micro origins of fluctuations by focusing on regional variation and its aggregate implications. Chapter 1 constructs estimates of the money supply in Ireland between 1840 and 1921. Chapter 2 develops annu
We develop a structural multivariate spatial regression model allowing us to incorporate both inter- and intralocation effects among different variables. The existing multivariate spatial regression approaches are not able to simultaneously account for these effects. The currently available models either ignore the intralocation effect between the variables, which may result to bias in estimation
How do we judge the direction of self-motion (i.e., heading) in the presence of independent object motion? Previous studies that examined this question confounded the effects of a moving object's speed and its position on heading judgments, and did not examine whether the visual system uses salient nonmotion visual cues (such as color contrast and binocular disparity) to segment a moving object fr
I denna avhandling undersöker vi existens av interna vågor och vågor på en ferrofluid. Interna vågor fortplantar sig på ytskiktet mellan två vätskor av olika densitet. Sådana vågor uppkommer till exempel naturligt i haven mellan brackvatten och saltvatten. En ferrofluid är en vätska innehållande små ferromagnetiska partiklar. När en sådan vätska utsätts för ett magnetfält så blir den magnetiseradThis thesis concerns travelling waves in a two-layer fluid and on a ferrofluid jet. We prove existence of several types of such waves by reformulating the corresponding governing equation as an infinite dimensional dynamical system, where an unbounded spatial coordinate is used as time. A center-manifold reduction is then employed to reduce the system to a locally equivalent finite dimensional sys
Purpose: The 4 kallikrein panel, commercially available as the 4Kscore®, is a statistical model that has been shown to accurately predict Gleason Grade Group 2 or greater (high grade) cancer on biopsy and the long-term risk of distant prostate cancer metastases. The panel includes 2 novel markers, namely intact prostate specific antigen and hK2. It has been questioned whether these 2 additional ma
Northern ecosystems are experiencing some of the most dramatic impacts of global change on Earth. Rising temperatures, hydrological intensification, changes in atmospheric acid deposition and associated acidification recovery, and changes in vegetative cover are resulting in fundamental changes in terrestrial-aquatic biogeochemical linkages. The effects of global change are readily observed in alt
Introduction: Medical treatment of women with idiopathic recurrent pregnancy loss is controversial. The objective was to assess the effects of different treatments on live birth rates and complications in women with unexplained recurrent pregnancy loss. Material and methods: We searched MEDLINE, Embase and the Cochrane Library, and identified 1415 publications. This systematic review included 21 r
Artikeln vill ge bakgrundshistoria och orientering om dagens situation för mi’kmaq, en etnisk folkgrupp, som främst bebor reservat på Kanadas ostkust. Historiken uppvisar en koloniserad grupp, som influerats av britternas annektering av provinsen och den franska, katolska missionen, men samtidigt finns idag en ny stolthet över att vara mi’kmaq, med reservatslivets mödor och glädjeämnen som gruppen
Det behövs en bredare förståelse för AI-teknologins sociala, etiska och rättsliga effekter, skriver sex företrädare för universitetsvärlden och näringslivet. Sverige har goda möjligheter att nå framgång i den kapplöpning som pågår när det gäller artificiell intelligens, AI. Men det kräver att politiker, universitetsvärlden och näringslivet samverkar och bygger upp en tvärvetenskaplig kompetens.
A critical factor for electronics based on inorganic layered crystals stems from the electrical contact mode between the semiconducting crystals and the metal counterparts in the electric circuit. Here, a materials tailoring strategy via nanocomposite decoration is carried out to reach metallic contact between MoS2 matrix and transition metal nanoparticles. Nickel nanoparticles (NiNPs) are success
Ljus kan användas till många saker, allt från att sända radiosignaler och skicka information i optiska fibrer, till att lysa upp hem och utvinna energi via solceller. Det ljus vi är mest vana vid som människor är ett intervall av våglängder mellan 400 och 700 nanometer (en nanometer är en miljarddels meter), som svarar mot alla synliga färger mellan rött och violett. Ett sätt att undersöka sammansIn this thesis we discuss a theoretical description of ultrafast and non-linear spectroscopy. Due to the high intensities and ultrashort pulse durations involved in such experiments, it is necessary to use an explicitly time-dependent formalism. In addition, many of the systems we have considered exhibit strong interactions between the constituent particles, such as electron-electron, electron-nuc
Light-use efficiency (LUE), which quantifies the plants' efficiency in utilizing solar radiation for photosynthetic carbon fixation, is an important factor for gross primary production estimation. Here we use satellite-based solar-induced chlorophyll fluorescence as a proxy for photosynthetically active radiation absorbed by chlorophyll (APARchl) and derive an estimation of the fraction of APARchl
Robust fitting of geometric models is a core problem in computer vision. The most common approach is to use a hypothesize-and-test framework, such as RANSAC. In these frameworks the model is estimated from as few measurements as possible, which minimizes the risk of selecting corrupted measurements. These estimation problems are called minimal problems, and they can often be formulated as systems
The utilization of lignocellulosic biomass to produce biofuels, such as bioethanol, has the potential to provide a sustainable alternative to fossil fuels, and thus mitigate greenhouse gas emissions from the transportation sector.Forest biomass is expected to be a significant source of such biomass, as it can serve as an abundant and sustainable feedstock for bioethanol production. It is unlikely
Background: A hip fracture is a common cause of morbidity, functional disability, and decreased health-related quality of life (HRQOL). With demographic changes showing a growing proportion of older people, hip fractures will be an increasing challenge for healthcare services in the future. Hip fractures threaten the independence of individuals in their everyday lives. In Sweden, more than one thiBackground: A hip fracture is a common cause of morbidity, functional disability, and decreased health-related quality of life (HRQOL). With demographic changes showing a growing proportion of older people, hip fractures will be an increasing challenge for healthcare services in the future. Hip fractures threaten the independence of individuals in their everyday lives. In Sweden, more than one thi
