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Antimicrobial activity of histidine-rich peptides is dependent on acidic conditions.

Synthetic peptides composed of multiples of the consensus heparin-binding Cardin and Weintraub sequences AKKARA and ARKKAAKA are antimicrobial. Replacement of lysine and arginine by histidine in these peptides completely abrogates their antimicrobial and heparin-binding activities at neutral pH. However, the antibacterial activity against Gram-negative (Escherichia coli, Pseudomonas aeruginosa) an

Linear Transmitter Design Using Nonlinear Analog Circuits

This dissertation deals with analog techniques at both the architecture and circuit design levels for designing power efficient linear radio-frequency (RF) transmitters. The use of nonlinear analog integrated circuits to implement certain critical signal processing functions for the multiplicative feedback and LINC techniques is investigated with the aim of improving the system performance in term

The Meta-Contrast Technique: relationships with personality traits and cognitive abilities in healthy women.

The relationship between test results from the Meta-Contrast Technique (MCT) and self-reports from Karolinska Scales of Personality (KSP), or the State Trait Anxiety Inventory (STAI-T), was investigated in 100 healthy women. Additionally, it was investigated whether age and cognitive abilities influenced the reports of picture recognition thresholds in the MCT. The results showed no agreement betw

Analytic contractions, nontangential limits, and the index of invariant subspaces

Let H be a Hilbert space of analytic functions on the open unit disc D such that the operator M. of multiplication with the identity function. defines a contraction operator. In terms of the reproducing kernel for H we will characterize the largest set Delta(H) subset of partial derivative D such that for each f, g is an element of H, g not equal 0 the meromorphic function f/g has nontangential li

A model of attentional impairments in autism: first steps toward a computational theory

A computational model with three interacting components for context sensitive reinforcement learning, context processing and automation can autonomously learn a focus attention and a shift attention task. The performance of the model is similar to that of normal children, and when a single parameter is changed, the performance on the two tasks approaches that of autistic children.

Tankar om våld och film

Analys av våldskildringar i amerikansk film, bland annat i Tjuren från Bronx (raging Bull, 1980)

Increased levels of plasma homocysteine are associated with nephropathy, but not severe retinopathy in type 1 diabetes mellitus

The reactive vascular-injuring amino acid homocysteine was measured in plasma samples from 79 well-characterized type 1 diabetic patients and 46 control subjects. Patients with proliferative retinopathy had higher homocysteine levels (15.0 +/- 6.3 mumols l-1; mean +/- SD, p less than 0.001; n = 42) than those with progressive retinopathy during a two-year period (10.4 +/- 1.6 mumols l-1; n = 12),

Few electron double quantum dots in InAs/InP nanowire heterostructures

We report on fabrication of double quantum dots in catalytically grown InAs/InP nanowire heterostructures. In the few-electron regime, starting with both dots empty, our low-temperature transport measurements reveal a clear shell structure for sequential charging of the larger of the two dots with up to 12 electrons. The resonant current through the double dot is found to depend on the orbital cou

Size-selectivity of the glomerular barrier to high molecular weight proteins: upper size limitations of shunt pathways

To evaluate the large pore radius of the glomerular capillary filter, plasma-to-urine fractional clearances of a number of endogenous proteins were assessed in normal and in nephrotic Wistar rats in which proximal tubular reabsorption had been inhibited using lysine. The proteins studied varied in radius from 16.2 A (Beta 2-microglobulin) to 90 A (alpha 2-macroglobulin). The nephrotic syndrome was

Direct colorimetric assay for rapid detection of rifampin-resistant Mycobacterium tuberculosis

The colorimetric 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay was standardized for direct detection of rifampin-resistant Mycobacterium tuberculosis in sputum samples. The sensitivity and specificity of the direct MTT assay matched those of the standard indirect susceptibility assay on 7H10 medium, and interpretable results were obtained for 98.5% of the samples within

IGF-I and IGFBP-3 augment transforming growth factor-beta actions in human renal carcinoma cells.

Renal cell carcinoma (RCC) is the most prevalent cancer of the kidney. In human RCC cells, we recently showed that insulin-like growth factor I (IGF-I) has growth-promoting effects regulated by IGF-binding protein 3 (IGFBP-3). In this study, the analysis was expanded to include the interaction between the IGF and transforming growth factor-beta (TGF-beta) systems in the human RCC cells Caki-2 (fro