OBJECTIVES: Improvement of skin fibrosis is part of the natural course of diffuse cutaneous systemic sclerosis (dcSSc). Recognising those patients most likely to improve could help tailoring clinical management and cohort enrichment for clinical trials. In this study, we aimed to identify predictors for improvement of skin fibrosis in patients with dcSSc.METHODS: We performed a longitudinal analys

BACKGROUND: Despite men being less prone to develop autoimmune diseases, male sex has been associated with a more severe disease course in several systemic autoimmune diseases. In the present study, we aimed to investigate differences in the clinical presentation of primary Sjögren's syndrome (pSS) between the sexes and establish whether male sex is associated with a more severe form of long-term

Taking a performance perspective of entrepreneurship as the point of departure, the social action of entrepreneurship is examined through an interactionist lens. In particular, it applies the micro-sociology of interactionism of Erving Goffman as expounded in his seminal essays ‘On Face-Work’ and ‘The Nature of Deference and Demeanour’. The paper explores entrepreneurship through a case study of a

At temperate latitudes, altricial birds and their nestlings need to handle night temperatures well below thermoneutrality during the breeding season. Thus, energy costs of thermoregulation might constrain nestling growth, and low nocturnal temperatures might require resources that parents could otherwise have invested into nestlings during the day. To manipulate parental work rate, we performed brAt temperate latitudes, altricial birds and their nestlings need to handle night temperatures well below thermoneutrality during the breeding season. Thus, energy costs of thermoregulation might constrain nestling growth, and low nocturnal temperatures might require resources that parents could otherwise have invested into nestlings during the day. To manipulate parental work rate, we performed br

The European Spallation Source will, once fully operational in 2025, be the world's brightest neutron source. The neutrons will be generated by bombarding a tungsten target with protons accelerated to 96\% the speed of light by electromagnetic fields confined in 155 radio-frequency cavities along the world's most powerful linear accelerator.This thesis has been motivated by the strict control spec

In early medieval and medieval Chinese narratives children appear as transformed objects, divine assistants, servants or messengers of underworld administrators or medical deities. The less supervision and thus the greater independence from adults a child had, the creepier and more potentially dangerous he was. Some of these child figures were assis- tants or messengers between a person’s body and

This thesis comprises three papers studying several mathematical models related to geometric Markov processes and random processes with reinforcements. The main goal of these works is to investigate the dynamics as well as the limiting behaviour of the models as time goes to infinity, the existence of invariant measures and limiting distributions, the speed of convergence and other interesting rel

In this conversational blog, we seek to explore slow movement in order to gain insight, challenge some of the norms and enjoy a conversation over tea! We aim to link degrowth and “slow” and explore whether slow could be compatible with degrowth and in what way.

OBJECTIVE: This study was undertaken to investigate the prevalence of celiac disease in children and adolescents with Down syndrome.MATERIAL AND METHODS: Forty-three children and adolescents with Down syndrome were screened for IgA-antigliadin antibodies (AGA) and IgA-antiendomysium antibodies (EMA). Patients found to be either AGA- or EMA-positive were investigated further with intestinal biopsy.

This paper evaluates the cost-effectiveness of renovating single-family houses to Passive House level, as compared to maintaining the existing buildings or renovating to building regulation level. The assessment involved life cycle cost analyses, and concerns the Swedish single-family housing stock constructed between 1961 and 1980, which accounts for about a third of Sweden’s two million single-fThis paper evaluates the cost-effectiveness of renovating single-family houses to Passive House level, as compared to maintaining the existing buildings or renovating to building regulation level. The assessment involved life cycle cost analyses, and concerns the Swedish single-family housing stock constructed between 1961 and 1980, which accounts for about a third of Sweden’s two million single-f

The prevalence of autoantibodies against the 65 kD isoform of glutamic acid decarboxylase (GAD65Ab), insulin (IAA), islet cells (ICA), thyroid peroxidase (TPOAb) and thyroglob-ulin (TgAb), in relation to HLA-DR types, was assessed in 310 (HLA in 280) twelve-year-old children during three-year follow-up. Altogether, 26.8% (83?10) of the children were found to carry at least one autoantibody. The HL

ATT PLÖJA MYCKET, LITE ELLER INGET ALLS Vi blir fler och fler människor på vår planet, och år 2050 beräknas vi vara så många som 10 miljarder. Det innebär att vi måste kunna producera mer mat på en lika stor eller till och med mindre yta jämfört med idag. En stor del av den mat vi konsumerar produceras antingen direkt eller indirekt på åkrar runt om i världen. För lantbrukare som är inriktade på vSoil microorganisms are important for climate regulation as well as for plant nutrition. In agricultural soils the microorganisms are affected by management choices, like which type of tillage that is used. Moldboard plowing, the most common tillage practice, increases mineralization which leads to soil organic carbon (SOC) loss, and may thus reduce soil quality. Conservation tillage practices inf

Aims Screening for atrial fibrillation (AF) using intermittent electrocardiogram (ECG) recordings can identify individuals at risk of AF-related morbidity in particular stroke. We aimed to validate the performance of an AF screening algorithm compared with manual ECG analysis by specially trained nurses and physicians (gold standard) in 30 s intermittent one-lead ECG recordings. Methods and result

The tight junction protein claudin-4 has been reported to be overexpressed in advanced ovarian cancer. We investigated the prognostic significance of claudin-4 overexpression and whether claudin-4 expression could predict platinum response in primary ovarian carcinoma (OC). Claudin-4 expression was evaluated by immunohistochemistry in a tissue microarray of 140 OCs. Multivariable Cox-regression mo

Background: Male breast cancer (BC) is rare, managed by extrapolation from female BC. The International Male BC Program aims to better characterize and manage this disease. We report the results of part I, a retrospective joint analysis of cases diagnosed during a 20-year period. Methods: Patients with follow-up and tumor samples, treated between 1990 and 2010, in 93 centers/9 countries. Samples w