Neuroblastomais a childhood tumour of the peripheral sympathetic nervous system. The pathogenesis has for a long time been quite enigmatic, as only very few gene defects were identified in this often lethal tumour(1). Frequently detected gene alterations are limited to MYCN amplification (20%) and ALK activations (7%)(2-5). Here we present a whole-genome sequence analysis of 87 neuroblastoma of al

Synaptosomes (isolated nerve terminals) have been studied for more than 40 years. The preparation allows aspects of transmitter metabolism and release to be studied ex vivo from specific brain regions of animals of any age. Conditions can be devised to enable the terminals to fire spontaneous action potentials, allowing the presynaptic control of glutamate exocytosis to be studied. Recent developm

Objectives: The objective of this study was to define metabolic normality and to investigate the cardiometabolic profile of metabolically normal obese. Design: Cross-sectional study conducted at 21 research centers in Europe. Subjects: Normal body weight (nbw, n = 382) and overweight or obese (ow/ob, n = 185) subjects free from metabolic syndrome and with normal glucose tolerance, were selected am

This review covers the recent literature on the geography of sustainability transitions and takes stock with achieved theoretical and empirical insights. The review synthesises and reflects upon insights of relevance for sustainability transitions following from analyses of the importance of place specificity and the geography of inter-organisational relations. It is found that these contributions

Neurodegenerative dementia, most frequently represented by Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), is often accompanied by altered sleeping patterns and excessive daytime sleepiness. Studies showing an association between the neuropeptide orexin and AD/DLB-related processes such as amyloid-β (Aβ)1-42 plaque formation, α-synuclein accumulation, and inflammation indicate that o

Background: A central theme in media psychology is how certain contemporary and dominant views may tend to perpetuate themselves by presenting a recurring picture we humans use to form our knowledge about the world. The present study is based on 1.5 million words from articles published online in the Swedish daily newspapers in 2010. We investigated which words were most (un-)common in articles co

Although several molecular pathways have been linked to type 2 diabetes (T2D) pathogenesis, it is uncertain which pathway has the most implication on the disease. Changes in the expression of an entire pathway might be more important for disease pathogenesis than changes in the expression of individual genes. To identify the molecular alterations in T2D, DNA microarrays of human pancreatic islets

Compounds with benzochromene and fluorene structures are common in nature and society, and they can have potentially useful biological activities. In this paper, conditions for the selective preparation of either a benzochromene or a fluorene from the same starting material are described. The procedure uses a reagent-controlled cyclization-demethylation to give the benzochromene, or an intramolecu

We report on the discovery of a generic piezoelectric field in strained core-shell compound semiconductor nanowires. We present the lattice-mismatch induced strain in epitaxial core-shell nanowires and show that it gives, very generally, rise to an internal piezoelectric field along the axis of the nanowire. This field results predominantly from atomic displacements in polar bonds and microscopic

The objective of the present study was to assess the safety and effectiveness of vernakalant hydrochloride injection (RSD1235), a novel antiarrhythmic drug, for the conversion of atrial fibrillation (AF) or atrial flutter to sinus rhythm (SR) Patients with either AF or atrial flutter were randomized in a 11 ratio to receive vernakalant (n = 138) or placebo (n = 138) and were stratified by an arrhy

NADPH and NADH mediate reductant flow between cellular processes, linking central carbon and energy metabolism with intermediary metabolism, stress defence and development. Recent investigations have revealed paths of functional interactions, and have suggested that mitochondrial NADPH oxidation, especially together with the oxidative pentose phosphate pathway, is an important regulator of the cyt

Theoretical approaches to learning in practice-based jazz improvisation contexts include situated learning and ecological perspectives. This article focuses on how interest-driven, self-sustaining jazz learning activities can be matched against the results of a recent Swedish investigation based on extensive qualitative interviews with jazz musicians regarding their views on the metaphor ‘storytel

Background Multiple myeloma cells uniformly overexpress CD38. We studied daratumumab, a CD38-targeting, human IgG1κ monoclonal antibody, in a phase 1-2 trial involving patients with relapsed myeloma or relapsed myeloma that was refractory to two or more prior lines of therapy. Methods In part 1, the dose-escalation phase, we administered daratumumab at doses of 0.005 to 24 mg per kilogram of body

Density forecasts contain a complete description of the uncertainty associated with a point forecast and are therefore important measures of financial risk. This paper aims to examine if the new more complicated models for financial returns that allow for time variation in higher moments lead to better out-of-sample density forecasts. Using two decades of daily Standard and Poor's 500 index return

The objective of the present study was to investigate whether ego-dystonic and ego-syntonic suicidal ideation occurred at different frequencies during antidepressant therapy. A blind evaluation has been performed on records of 100 suicides with a primary severe depression and 100 matched controls, admitted to the Department of Psychiatry, Lund, Sweden. Ego-dystonic suicidal ideation was more commo

A graphene monolayer on single crystal Ir(111) has been studied using angle-resolved photoemission spectroscopy (ARPES) before and after exposure to atomic oxygen. With increasing oxygen coverage the Dirac cone, centered on the K-point of the Brillouin zone, broadens and finally transforms to a parabolic rather than linear feature, introducing a pronounced energy bandgap at the Fermi level. The op

A palynological investigation of lower Paleocene (lower Teurian) marine sediments of the Abbotsford Formation, exposed in the Fairfield Quarry, Dunedin, New Zealand, reveals a well-preserved association of dinoflagellate cysts and miospores. Thirty-six dinoflagellate species representing 26 genera were recorded, including one new peridinioid dinoflagellate species, Trithyrodinium partridgei charac

Biennial sugar beet (Beta vulgaris spp. vulgaris) is a Caryophyllidae that has adapted its growth cycle to the seasonal temperature and day length variation of temperate regions. This is the first time a holistic study of the expression pattern of non-symbiotic hemoglobins (nsHbs) is being carried out in a member of this group and under two essential environmental conditions for flowering, namely