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Only a minority of patients treated with antipsychotics in clinical studies continue their treatments throughout a longer study period. Few studies address this issue from a lifetime perspective. In this naturalistic study, we aimed at analysing the prescription pattern of antipsychotic drugs among a sample of Swedish patients with a diagnosis of psychotic illness, from the first contact with psyc
A strongly coupled dipolar fluid confined in a sphere has been examined by Monte Carlo simulations using a modified distance-dependent pair interaction to emulate retardation effects. The effective dipole-dipole interaction and a property closely related to Kirkwood's g-factor have been analyzed for potentials with different distances at which the retardation effects became effective. The retardat
In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water concentration profile data inside the gel layer, using two different diffusion models. The water concentration profiles were obtained from magnetic resonance microimaging data whi
Complex hydrides are very promising candidates for future light-weight solid state hydrogen storage materials. The present work illustrates detailed characterization of such novel hydride materials on different size scales by the use of synchrotron radiation and neutrons. The comprehensive analysis of such data leads to a deep understanding of the ongoing processes and mechanisms. The reaction pat
Secretion from many endocrine cells is a result of calcium-regulated exocytosis due to Ca(2+) influx. Using the patch-clamp technique, voltage pulses can be applied to the cells to open Ca(2+) channels, resulting in a measurable Ca(2+) current, and evoke exocytosis, which can be seen as an increase in membrane capacitance. A common tool for evaluating the relation between Ca(2+) influx and exocyto
Approximately 50% of children born with cleft palate present speech difficulties around 3 years of age, and several studies report on persisting phonological problems after palatal closure. However, studies on early phonology related to cleft palate are few and have so far mainly been carried out on English-speaking children. Studies on phonology related to cleft palate in languages other than Eng
This study (N = 102 women) evaluated the time course of posttraumatic stress symptomatology (PTSS) at different stages of nonmetastastic cancer diagnosis and treatment: during treatment, at the end of treatment, and at a 6-12 months follow-up. We also assessed the contribution of demographic, trait, and state predictors to PTSS, and coping processes as proximal mediators of the relation between Ty
Crystal phase control in single III-V semiconductor nanowires has emerged recently as an important challenge and possible complement to conventional bandgap engineering in single material systems. Here we investigate a supply interruption method for precise crystal phase control in single nanowires. The nanowires are grown by metalorganic vapor phase epitaxy using gold particles as seeds and are a
Partially premixed combustion has the potential of high efficiency and simultaneous low soot and NOx emissions. Running the engine in partially premixed combustion mode with high octane number fuels has the advantage of a longer premix period of fuel and air which reduces soot emissions, even at higher loads. The problem is the ignitability at low load and idle operating conditions. The objective
The fate of iron (Fe) in freshwaters is largely influenced by chemical interactions with natural organic matter (NOM). However, the knowledge about the molecular structure of the Fe species formed in association with aquatic NOM is still limited. In this work we have studied the interactions between Fe(III) and aquatic organic matter from the Suwannee River at a range of pH values and Fe concentra
Calibration of network nodes using only time differences of arrival (TDOA) measurements opens up for interesting applications in wireless ad-hoc sensor networks, e.g. finding the positions of cell phones by only ambient sounds or radio. We present two novel approaches for the problem of self-calibration of network nodes using only TDOA when both receivers and transmitters are unsynchronized. We co
Radio frequency identification (RFID) is a compelling technology for Internet of Things (IoT). Ultra-wideband (UWB) technology is one promising wireless technique for future RFID, especially for high-throughput sensing applications. On-off keying UWB RFID system provides high pulse rate but suffers severe collisions that limit the system throughput. This paper proposes to utilize low pulse rate co
A transition from gabbro to eclogite has been investigated at Vinddoldalen in south-central Norway, with the aim to link reaction textures to metamorphic zircon growth and to obtain a direct U-Pb zircon age of the metamorphic process. In the different rocks of the transition zone zircon occurs as (I) igneous prismatic grains, (II) metamorphic polycrystalline rims and pseudomorphs after baddeleyite
A Zn2+-bis-terpyridine coordination polymer is investigated by single-molecule fluorescence spectroscopy (SMS). The bis-terpyridine ligands of the coordination polymers bear conjugated chromophores connecting the terpyridine spheres of the ligands, which resemble structural features of MEH-PPV. To the best of our knowledge this paper presents the first systematic SMS study on Zn2+-bis-terpyridine
We examined the transduction efficiency of different adeno-associated virus (AAV) capsid serotypes encoding for green fluorescent protein (GFP) flanked by AAV2 inverted terminal repeats in the nonhuman primate basal ganglia as a prelude to translational studies, as well as clinical trials in patients with Parkinson's disease (PD). Six intact young adult cynomolgus monkeys received a single 10 mu l
We determined whether single nucleotide polymorphisms (SNPs) previously associated with diabetogenic traits improve the discriminative power of a type 2 diabetes genetic risk score. Participants (n = 2,751) were genotyped for 73 SNPs previously associated with type 2 diabetes, fasting glucose/insulin concentrations, obesity or lipid levels, from which five genetic risk scores (one for each of the
The hydrogen abstraction of CH3OH by C-2 (A(3)Pi(u)) has been investigated by direct ab initio dynamics over a wide temperature range 200-3000 K. The potential energy surfaces (PESs) have been constructed at the UCCSD(T)/aug-cc-pVTZ//UMP2/6-311++G(d,p) levels of theory. Two different hydrogen abstractions on the methyl and hydroxyl sites of methanol are considered. For the methyl H-abstraction, it
BACKGROUND: Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP)-containing nerves surround cerebral blood vessels. The peptides have potent vasodilator properties via smooth muscle cell receptors and activation of adenylate cyclase. The purpose of this study was to describe the effects of two putative VIP/PACAP receptor antagonists and the distribution of
