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Despite high-hyperdiploid acute lymphoblastic leukaemia (HD-ALL) being the most common subgroup of paediatric ALL, its aetiology remains unknown. Genome-wide association studies have demonstrated association at 10q21.2. Here, we sought to determine how this region influences HD-ALL risk. We impute genotypes across the locus, finding the single nucleotide polymorphism rs7090445 highly associated wi

Among the numerous proposals to explain the nature of dark matter, there is the weakly interacting massive particle (WIMP) scenario, which is based on a simple assumption that dark matter was in thermal equilibrium in the early hot Universe, and its particles have mass and interactions not too different from the massive particles in the standard model. In this Progress Article we overview the infe

Skin photoprotection is commonly believed to rely on the photochemistry of 5,6-dihydroxyindole (DHI)- and 5,6-dihydroxyindole-2-carboxylic acid (DHICA)-based eumelanin building blocks. Attempts to elucidate the underlying excited-state relaxation mechanisms have been partly unsuccessful due to the marked instability to oxidation. We report a study of the excited-state deactivation of DHI using ste

The detailed pathways of photoactivity on ultrafast time scales are a topic of contemporary interest. Using a tabletop apparatus based on a laser plasma X-ray source and an array of cryogenic microcalorimeter X-ray detectors, we measured a transient X-ray absorption spectrum during the ferrioxalate photoreduction reaction. With these high-efficiency detectors, we observe the Fe K edge move to lowe

Selected reaction monitoring (SRM) is a targeted mass spectrometry technique that enables precise quantitation of hundreds of peptides in a single run. This technique provides new opportunities for multiplexed protein biomarker measurements. For precision plant breeding, DNA-based markers have been used extensively, but the potential of protein biomarkers has not been exploited. In this work, we d

Castleman's Disease (CD) is a rare lymphoproliferative disorder accompanied by marked systemic inflammatory response. Morphological diagnosis of CD requires biopsy of the whole of the involved lymph node tissue. Three histologic variants have already been described in CD morphology (hyaline vascular, plasma-cell, and mixed). In this study, we report a case of a multicentric Castleman's disease of

The aim of this study was to describe how former male patientsperceive life after recovery from an eating disorder. A qualitativemethod with a phenomenographic approach was used toidentify ways of experiencing recovery. Two descriptive categorieswere developed: body acceptance and self-worth. Six conceptionsdescribe how recovered patients now relate in a balanced way toexercise and food, using strThe aim of this study was to describe how former male patients perceive life after recovery from an eating disorder. A qualitative method with a phenomenographic approach was used to identify ways of experiencing recovery. Two descriptive categories were developed: body acceptance and self-worth. Six conceptions describe how recovered patients now relate in a balanced way to exercise and food, usi

Dagens moderna samhälle är ett i många avseenden sårbart samhälle. Det har inte varit någon medveten strävan utan är en konsekvens av att samhället till stor del kommit att bli uppbyggt kring försörjningskedjor (supply chains). I dessa hårt integrerade kedjor med ett flertal ofta globalt utspridda led flyter en ständig ström av fysiska varor, tjänster samt kombinationer av varor och tjänster.Det e

Objectives: The aim of the current study is toinvestigate what males experience as helpful in theirrecovery process from eating disorders (ED).Methods: Qualitative in-depth interviews within aphenomenological approach, and using contentanalysis to excavate overarching text themes.Setting: Norway and Sweden.Participants: Included were 15 males with an agerange from 19 to 52 years. Duration of illneOBJECTIVES: The aim of the current study is to investigate what males experience as helpful in their recovery process from eating disorders (ED).METHODS: Qualitative in-depth interviews within a phenomenological approach, and using content analysis to excavate overarching text themes.SETTING: Norway and Sweden.PARTICIPANTS: Included were 15 males with an age range from 19 to 52 years. Duration of

The global challenges posed by demographic change call for more senior-friendly medication packaging. This paper presents a comprehensive integrated view and synthesis of the literature on medication packaging and older people. Considering the multidisciplinary nature of the research field, a systematic review was conducted in four databases (Scopus, Web of Science, Medline and Engineering Village

Pharmaceutical packaging is linked to important demographic changes. Aging ofpopulations is one of the demographic changes which has called for more attention, especially in well-developed countries. The increase in life expectancy represents a positive consequence of years of research, development of medications, and improvement in life habits. In spite of that, the growth in the number of people

PURPOSE: The aim of this study was to describe long-term adjustment to life with an ileal pouch-anal anastomosis after surgery for ulcerative colitis, to investigate the relationship of pouch function to adjustment, and to explore factors affecting quality of life.METHODS: A total of 369 patients treated between 1982 and 1993 were included in the study. Questionnaires designed to assess bowel (pou

PURPOSE: Rectal cancer is the most common reason for a person to undergo ostomy surgery. The aim of this study was to assess concerns and health-related quality of life (HRQOL) before surgery and during the first 6 months following ostomy surgery in the presence of rectal cancer.SUBJECTS AND SETTINGS: The sample comprised 57 patients at a university hospital in Gothenburg, Sweden. Their median age

Skiftande vårdkvalité hotar patientsäkerheten inom ambulanssjukvården. Nu måste regeringen och Socialstyrelsen skapa nationella riktlinjer, skriver Nätverket för utbildning av ambulanssjuksköterskor .