Filtyp
The mucin O-glycosylation of 10 individuals with and without gastric disease was examined in depth in order to generate a structural map of human gastric glycosylation. In the stomach, these mucins and their O-glycosylation protect the epithelial surface from the acidic gastric juice and provide the first point of interaction for pathogens such as Helicobacter pylori, reported to cause gastritis,
Mucins in the gastric mucus layer carry a range of glycan structures, which vary between individuals, can have antimicrobial effect or act as ligands for Helicobacter pylori. Mucins from various individuals and disease states modulate H. pylori proliferation and adhesin gene expression differently. Here we investigate the relationship between adhesin mediated binding, aggregation, proliferation an
BACKGROUND: Helicobacter heilmannii is a zoonotic bacterium associated with gastric disease in humans. We recently showed that H. heilmannii binds to human gastric mucins and epithelial cells and highlighted a potential role for the murine Muc13 mucin in gastric Helicobacter colonization. The aims of this study were to investigate the role of the H. heilmannii hof gene locus encoding HofH/F/E/G/C/
Helicobacter heilmannii naturally colonizes the stomachs of dogs and cats and has been associated with gastric disorders in humans. Nine feline Helicobacter strains, classified as H. heilmannii based on ureAB and 16S rRNA gene sequences, were divided into a highly virulent and a low-virulence group. The genomes of these strains were sequenced to investigate their phylogenetic relationships, to def
Ambulatory electrocardiogram (ECG) monitoring frequently identifies incidental arrhythmias, but their prevalence in community-based atrial fibrillation (AF) screening remains uncertain. For this systematic review, we searched PubMed, Embase, Cochrane, and CINAHL through January 2025 for studies on ECG abnormalities in community-based screening. Eligible studies included randomized trials or observ
Imaging techniques have a long history in archeology, from the ruins depicted during the Grand Tour to today's large-scale photogrammetric surveys. Orthophotos generated with photogrammetry are currently extensively used in archeology: a key challenge in this new documentation paradigm lies in the semantic segmentation of such pixel matrices, a process increasingly aided by Machine Learning. This
This paper presents the integrated study of the funerary ara of Ofilius Ianuarius, discovered within the burial complex of Via Appia Antica 39, and explores its digital stratigraphic recontextualisation through two 3D semantic workflows. The research aims to evaluate the potential of stratigraphic 3D modelling as a tool for post-excavation analysis and transparent archaeological interpretation. St
The present research seeks to give a general overview about the wooden tablets found in Vindolanda. Firstly, the research will focus on the tablet as an “indirect” source of data: any kind of information (not directly related to the text content) which could be revealed by, for instance, the language or type of writing. Secondly, different types of texts will be analysed and compared (if possible,
Recent advances in generative Artificial Intelligence (AI) have rapidly transformed research and practice across the Cultural Heritage domain. While several studies have investigated AI applications in documentation, analysis and dissemination, a focused and critical assessment of generative AI within 3D virtual reconstruction workflows is still lacking. This paper presents a systematic review of
The intricate relationship between Cultural Heritage, Landscapes, Cultural Identities, and Local Communities requires a deeply interdisciplinary approach. By fostering a sense of place and community, Cultural Heritage strengthens social bonds, enhances well-being, and supports civic engagement. In fact, individual disciplines often struggle to establish a common framework. Thus, this study aims to
The increasing use of geophysical investigations for archaeological purposes is now provided also by Italian reforms about preventive archaeology. They allow not only the discovery or the spatial definition of possible buried archaeological evidence, but they are also able to define the state of preservation of ancient structures. The Bocca delle Menate archaeological site is in Comacchio village
Background: Selegiline, rasagiline, safinamide, and zonisamide are commonly used with levodopa to manage motor fluctuations in Parkinson’s disease (PD). This study compared the efficacy and safety of these agents as adjuncts to levodopa in Asian PD patients with motor fluctuations. Methods: A Bayesian network meta-analysis (NMA) was conducted. Randomized controlled trials (RCTs) published from dat
Municipal housing companies have been recognised for their potential in taking on a leadership role in terms of energy efficiency in buildings, raising the question of what the transaction cost barriers are in these companies’ internal operations for undertaking energy efficiency measures. In this study, we thus explore transaction costs barriers in municipal housing companies in Sweden. Data on q
In La Guajira, a semi-arid region in northern Colombia, groundwater constitutes the primary water reserve for Wayúu communities. However, its management is often reduced to technical metrics of depth and extraction, rendering invisible the territorial and embodied knowledges that sustain life. Drawing on Latin American feminist political ecology and the water–body–territory framework, this article
Background Circadian rhythms regulate immune cell trafficking and function, and emerging clinical data suggest that the timing of immune checkpoint inhibitor (ICI) administration may influence efficacy. In advanced disease, later-day administration has been associated with inferior outcomes. Whether this applies to neoadjuvant ICI in resectable stage III–IV melanoma is unknown. Methods This retros
With zoonotic outbreaks on the rise, rapid and accurate infectious disease diagnostics are critical for both human and animal health. Traditional lateral flow assays lack sensitivity and specificity, while isothermal amplification methods like LAMP, though rapid, can be hindered by optical detection issues. We present an electrochemical nucleic acid amplification test (NAAT) that combines isotherm
The human stomach is a harsh and fluctuating environment for bacteria with hazards such as gastric acid and flow through of gastric contents into the intestine. H. pylori gains admission to a stable niche with nutrient access from exudates when attached to the epithelial cells under the mucus layer, whereof adherence to glycolipids and other factors provides stable and intimate attachment. To reac
BACKGROUND AND OBJECTIVE: Chronic breathlessness is common and often leads to avoidance of symptom-provoking activities. Expectations of breathlessness influence behaviour and symptom perception, but the accuracy of these expectations remains unclear. The aim of this study was to examine the relationship between expected and experienced breathlessness, the moderating role of mental states, determi
