Renal cell carcinoma (RCC) is a tumour type with an indolent growth pattern and rather vague symptoms. The present study developed a platform for liquid biopsy of RCC based upon the isolation of circulating tumour cells (CTCs). Founded on the observation that RCC tumour cells are considerably larger than leucocytes, the present study employed a microfluidics-based system for isolation of RCC CTCs

The formulation of semolina pasta with reduced starch digestibility is of prime importance to deal with the adverse effects of the intake of rapidly digested carbohydrates on human health. This work focused on the effects of the production method (extrusion and lamination) and the addition of commercial Type 2 resistant starch (RS) on the molecular organization and in vitro starch digestibility of

In the challenge to reduce CO2, NOx and PM emissions, the application of natural gas or biogas in engines is a viable approach. In heavy duty and marine, either a conventional dual fuel (CDF), or a reactivity-controlled compression ignition (RCCI) approach is feasible on existing diesel engines. In both technologies a pilot diesel injection is used to ignite the premixed natural gas. However, the

Recycling is an important area to improve to reduce negative impact on the environment. With increased material recovery, less virgin materials are needed to provide the same benefits for the society. Aluminium is an important metal in the efforts to reduce negative climate impact. Demand for wrought aluminium will heavily increase with electrification of vehicles. However, with today’s recycling,

Driven by the Paris agreement and tightening IMO regulations, the marine sector is focusing on lowering engine emissions and moving to low-carbon fossil or renewable fuel such as methane. The dual-fuel concept allows the usage of methane as main energy-source in diesel engines. A small pilot diesel injection acts as an ignition source for the premixed methane. It was investigated how NOx formation

En fråga som tidigare inte fått mycket uppmärksamhet, men som på senare tid hamnat i fokus, är utrymningsmöjligheterna vid brand i byggnader där vertikal förflyttning är en förutsättning. Sedan terroristattacken mot World Trade Center 2001 har flertalet studier belyst att användandet av hissar för utrymning skulle kunna vara en möjlig lösning för att effektivisera utrymningen av höga byggnader. TrAs tall buildings and deep underground structures around the world increase in both numbers and complexity, the issues with evacuation of such structures, e.g., fatigue during evacuation or difficulties for people with functional limitations to evacuate, become more prominent. Elevator evacuation could be a possible solution to these matters but in order for such elevators to be an effective solut

Purpose: To develop self-navigated motion correction for 3D silent zero echo time (ZTE) based neuroimaging and characterize its performance for different types of head motion. Methods: The proposed method termed MERLIN (Motion Estimation & Retrospective correction Leveraging Interleaved Navigators) achieves self-navigation by using interleaved 3D phyllotaxis k-space sampling. Low resolution na

This paper explores the idea of the entrepreneurial university and how it differs in diverse regional and institutional settings. From the analysis of university engagement in a regional economic development programme in fifteen city-regions in England (UK), this study identifies three roles that entrepreneurial universities play in regional economic development as growth supporter, steerer, and d

BackgroundAdrenomedullin is a vasoactive hormone with potentially prognostic and therapeutic value, which mainly has been investigated in intensive care unit (ICU) settings. The triaging in the emergency department (ED) of patients to the right level of care is crucial for patient outcome.ObjectivesThe primary aim of this study was to investigate the association of bioactive adrenomedullin (bio-AD

Due to limited groundwater resources in arid and semi-arid areas, conjunctive use of surface water and groundwater is becoming increasingly important. In view of this, there are needs to improve the methods for conjunctive use of surface and groundwater. Using numerical models, optimization algorithms, and machine learning, we created a new comprehensive methodological structure for optimal alloca

Rhenium(I)-carbonyl-diimine complexes have emerged as promising photocatalysts for carbon dioxide reduction with covalent organic frameworks recognized as perfect sensitizers and scaffold support. Such Re complexes/covalent organic frameworks hybrid catalysts have demonstrated high carbon dioxide reduction activities but with strong excitation energy-dependence. In this paper, we rationalize this

New 4th-generation synchrotron sources, with their increased brilliance, promise to greatly improve the performances of coherent X-ray microscopy. This perspective is of major interest for crystal microscopy, which aims at revealing the 3D crystalline structure of matter at the nanoscale, an approach strongly limited by the available coherent flux. Our results, based on Bragg ptychography experime

Background: In Europe, the frequency, intensity, and geographic range of West Nile virus (WNV)-outbreaks have increased over the past decade, with a 7.2-fold increase in 2018 compared to 2017, and a markedly expanded geographic area compared to 2010. The reasons for this increase and range expansion remain largely unknown due to the complexity of the transmission pathways and underlying disease dr

The application of a formulation on the skin represents an effective way to deliver bio-active molecules for therapeutical purposes. Moreover, the outermost skin layer, the stratum corneum, can be overcome by employing chemical permeation enhancers and edge activators as components. Several lipids can be considered as permeation enhancers, such as the ubiquitous monoolein, one of the most used bui

The studies of structural, optical and luminescent properties of undoped Gd3AlxGa5-xO12 (x = 0,1,2,3) and Gd2YAl2Ga3O12 mixed crystals were carried out. Mixed crystals composition and lattice parameters were determined using EDX and XRD techniques. The distribution of cations between sites with different symmetry was obtained using Rietveld method. The spectral dependence of refraction coefficient

The skate Leucoraja erinacea has an elaborately shaped pupil, whose characteristics and functions have received little attention. The goal of our study was to investigate the pupil response in relation to natural ambient light intensities. First, we took a recently developed sensory-ecological approach, which gave us a tool for creating a controlled light environment for behavioural work: During a

It is shown that the equation of motion of the one-particle Green function of an interacting many-electron system is governed by a multiplicative time-dependent exchange-correlation potential, which is the Coulomb potential of a time-dependent exchange-correlation hole. This exchange-correlation hole fulfills a sum rule, a generalization of the well-known sum rule of the static exchange-correlatio