Tau is an axonal microtubule-binding protein. Tau pathology in brain and increased tau concentration in the cerebrospinal fluid (CSF) are hallmarks of Alzheimer’s disease (AD). Most of tau in CSF is present as fragments. We immunoprecipitated tau from CSF and identified several endogenous peptides ending at amino acid (aa) 123 or 224 using high-resolution mass spectrometry. We raised neo-epitope-s

The Large Gain Theorem is an input-output stability result with intriguing applications in the field of control systems. This paper aims to increase understanding and appreciation of the Large Gain Theorem by presenting an interpretation of it for linear time-invariant systems using the well-known Nyquist stability criterion and illustrative examples of its use. The Large Gain Theorem is complemen

In this paper we derive the finite-sample distribution of the estimated weights of the tangency portfolio when both the population and the sample covariance matrices are singular. These results are used in the derivation of a statistical test on the weights of the tangency portfolio where the distribution of the test statistic is obtained under both the null and alternative hypotheses. Moreover, w

Abstract: Coagulation of cellulose solutions is a process whereby many useful materials with variable microstructures and properties can be produced. This study investigates the complexity of the phase separation that generates the structural heterogeneity of such materials. The ionic liquid, 1-ethyl-3-methylimidazolium acetate ([C2mim][OAc]), and a co-solvent, dimethylsulfoxide (DMSO), are used t

Here we present a study of the abundance and orientation of planar deformation features (PDFs) in the Vakkejokk Breccia, a proposed lower Cambrian impact ejecta layer in the North-Swedish Caledonides. The presence of PDFs is widely accepted as evidence for shock metamorphism associated with cosmic impact events and their presence confirms that the Vakkejokk Breccia is indeed the result of an impac

Water body extraction (WBE) has attracted considerable attention in the field of remote sensing image analysis. Herein, we present an enhanced deep convolutional encoder-decoder (DCED) network (or Deep U-Net) specifically tailored to WBE from remote sensing images by applying superpixel segmentation and conditional random fields (CRFs). First, we preclassify the entire remote sensing image into th

Recognizing that two elements within a sequence of variable length depend on each other is a key ability in understanding the structure of language and music. Perception of such interdependencies has previously been documented in chimpanzees in the visual domain and in human infants and common squirrel monkeys with auditory playback experiments, but it remains unclear whether it typifies primates

I Sverige inträffar runt 5500 bränder i bostäder årligen och i ca 80 av dessa bränder omkommer en eller flera personer. Det finns en långsamt nedåtgående trend för antalet omkomna i landet och världen, men nedgången är långsam och det finns inte heller några tydliga indikationer på vad denna nedgång kan beror på.Syftet med detta arbete är att studera olika byggnadstekniska faktorer i bostäder där The purpose of this work is to study fatal residential fires and see if they are correlated with any specific building characteristics. In this report, data on fatal fires are paired with data about the properties where the fires occurred. The analysis has shown that apartment buildings are overrepresented among properties with fatal fires compared to single-family units and agricultural units. It

BackgroundPower output and force development during exercise are thought to be important indices of performance in elite athletes. The aim of this preliminary study was to determine the forces applied at the footrest during ergometric kayaking in individual kayakers at different competitive levels.MethodsThree elite female kayakers participated voluntarily in the study. Oxygen consumption (VO2) an

Background and Aims: The risk of synchronous and metachronous colorectal cancer is influenced by heritable and environmental factors. As a basis for comparative studies, we provide population-based estimates of synchronous and metachronous colorectal cancer with a focus on non-heritable cases. Material and Methods: Based on data from national Danish cancer registers, we estimated the proportion of

Purpose: To investigate the prevalence of depressive symptoms, pain (headaches and stomachaches), and analgesic consumption in addition to the association between depressive symptoms and analgesic consumption among adolescents. Design and methods: This cross-sectional study was conducted in southern Sweden. The survey was distributed among students in grade 8 (aged 13–15 years, n = 878). Results:

This paper shows that political attitudes are linked to cooperative behavior in an incentivized experiment with a large sample randomly drawn from the Danish population. However, this relationship depends on the way the experiment is framed. In the standard game in which subjects give to a public good, contributions are not linked to political attitudes. In an economically equivalent version, in w

The Gaick is an enigmatic glaciated landscape in the Central Grampians, Scotland, dominated by an expansive dissected plateau. Previous studies have postulated widely differing interpretations of the glacial landforms and current understanding of the glacial events in this area is partly restricted by the absence of detailed glacial geomorphological mapping. To address this issue, we present a com

Due to their wide adaptability to different application fields spanning from opinion dynamics to biology, the analysis of evolutionary dynamics is a compelling problem in the science of networks and systems. In this paper, we deal with controlled evolutionary dynamics in networks. We discuss a novel approach to model these phenomena, which enables us to estimate the duration of the process dependi

The aggregation of fibrils of hyperphosphorylated and C-terminally truncated microtubule-associated tau protein characterizes 80% of all dementia disorders, the most common neurodegenerative disorders. These so-called tauopathies are hitherto not curable and their diagnosis, especially at early disease stages, has traditionally proven difficult. A keystone in the diagnosis of tauopathies was the d

Connected autonomous vehicles and industry 4.0 productions scenarios require ultra-reliable low-latency communication links. The varying positions of transmitter, reflecting objects and receiver cause a non-stationary time- and frequency-selective fading process. In this paper, we present the necessary hardware architecture and signal processing algorithms for a real-time geometry-based channel em

In order for a work on entrepreneurship to be published and attract attention, it must be interesting. The aims of this study are to understand why entrepreneurship scholars perceive entrepreneurship studies as interesting, what they consider interesting, and how they distinguish themselves from management scholars in their perception of interestingness. The study is based on responses from 915 en

The new dataset and web application 'Coin production in the Low Countries: fourteenth century to the present' provides scholars with user-friendly access to mintmasters' accounts going back to the Middle Ages. They give insight into the production of legal tender (within the Low Countries and occasionally elsewhere as well), and provide access to such variables as regional production figures and c

As different social groups are directly and indirectly confronted with diverse forms of police practices, different sectors of the population accumulate different experiences and respond differently to the police. This study focuses on the everyday experiences of the police among ethnic minority young people in the Nordic countries. The data for the article are based on semi-structured interviews

recension av Demokratins drivkrafter. Kontext och särdrag i Finlands och Sveriges demokratier, (H. Meinander, P. Karonen & K. Östberg, red.), Helsingfors/Stockholm 2018