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Developing a novel therapeutic product for the treatment of type 2 diabetes (T2D) is a long, resource-intensive process. Novel biomarkers could potentially aid clinical trial design by shortening clinical trials or enabling better prediction of at-risk populations and/or disease progression. Novel clinical trial designs could lead to reduced costs of development and less burden to patients, due to
Removing bus stops is often a prerequisite for introducing faster, more reliable, and more frequent rail or coach services in rural areas. Despite the potentially higher quality of service through trains or coaches, however, the bus-stop removals often become stumbling blocks. It is sometimes feared that the alterations to the public transport network will pose a threat to the possibilities of liv
Det antika Athen hade sin första blomstringstid under 400- och 300-talen f.Kr. Det hade då en ledande ställning i den grekiska världen, och från den tiden härstammar mycket av det som väckt senare tiders beundran – klassisk skulptur, arkitektoniska mästerverk som Parthenon, dramerna som fortfarande spelas på våra teatrar, Sokrates, Platons och Aristoteles landvinningar inom tankens värld. Detta är
This paper proposes a critical assessment of the jurisprudence of the Inter-American Court of Human Rights (IACRTHR) regarding the systemic integration of the provisions enshrined in the American convention on human rights (ACHR), under the light of the developments of the corpus juris of international human rights law. By incorporating the evolution in the interpretation of human rights law into
Accurately manufactured gears require a reliable, holistic, and fast inspection method. Standardised geometrical parameters enable a consistent and regulated inspection of gears; however, current inspection methods include only a limited set of measurements for gears at specific locations. Therefore, a method to obtain holistic three-dimensional (3D) measurements with an optical inspection was tho
Information systems are key enablers for the integration and reliable management of the product development process. Information systems are the backbone that connects various sub-processes and enables flexible product customization. Fast, robust, and cost-efficient product adaptation is especially important in one-of-a-kind production. This paper presents a transformation of the product developme
The smart factories that are already beginning to appear employ a completely new approach to product creation. Smart products are uniquely identifiable, know their current status and alternative routes to achieving their target state. The embedded manufacturing systems are vertically networked with business processes and horizontally connected to disperse value networks that can be managed in real
Being able to predict temperature rise inside a machine is as important as predicting its performance and life. Because temperature measurements and computational thermal simulations can be time consuming, thermal paths inside the through-flow universal motor were described by means of simple lumped parameter thermal network. Once the model was built, its unknown convection coefficients were tuned
The results of a numerical simulation of meshing polymer and composite gears are presented in the paper. The numerical model used for simulations was built in Ansys Workbench 15.0, using the finite element method to obtain the solution. The results are related to the gear tests, performed by the authors and presented in the literature. A detailed stress and strain analysis of meshing gears is pres
This paper numerically investigates the flow around a moving vehicle sheltered by a wind barrier. Flow control strategy aimed at reducing the aerodynamic loads on the road vehicles requires a detailed knowledge of the reference flow. Exploratory study is conducted in under-standing the flow physics involved in the wind barrier vehicle protection. Transient nature of the crosswind gust is represent
The paper presents an application of concurrent process planning and scheduling into the manufacturing company of turned parts. The first topic is strategic resource optimisation in the phase of new products process plan development. The second topic is how to handle consequences of unplanned events like urgent order from an important customer or a machine brake down. In order to optimise the effi
Supply chain management and early involvement of suppliers into product development process is one of the key elements of concurrent engineering. Internet based Product Lifecycle Management (PLM) system can improve communication between customers and suppliers. In the case study is presented a communication model and configuration of the PLM system that supports a second tier system supplier in au
Technical innovations in the area of manufacturing logistics are being introduced partially and thus not exploiting their full potential. In order to optimise the efficiency of turning manufacturing processes, the process has been analysed and fundamentally re-engineered. All data from production (operations, quantities, date, time duration of operations, etc.) are now located in ERPsystem. It pro
After detecting the customer needs it is possible to define functional requirements and set the design goal. The latter is represented by a target defined specification list of requirements. Such defined functions can serve as a basis for the concept, created by means of the morphological matrix. The optimum solution is selected after a rough assessment of results from the technical and economic p
The presented work describes a computational method for carrying out a detailed and thorough examination of the flash temperature rise (i.e. the local’instantaneous’ temperature increase on a contact interface, due to frictional effects) present on the tooth flanks of a polymer gear pair, composed of a combination of POM and PA66 thermoplastics, during a given meshing cycle. The method involves a
The existing models for the conversion and design of polymer gears are only valid for involute gears. This research was focused on S-gears, a specific type of gear profile which has more favorable contact conditions and greater root thickness when compared to involute gears. S-gears design is currently based on tests, experience, and the use of numerical simulations. Due to the lack of a simple ca
Tropical evergreen forests contribute an important part to the interannual variability (IAV) of the global terrestrial gross primary productivity (GPP). Due to its year-round growing-season, high minimum carbon uptake (GPPmin) and dry season greening-up, the key processes driving the GPP variability across seasonal to interannual scale are still in debate. Here, we analyzed the time-series of FLUX
Agricultural ecosystems have faced dramatic changes during past decades, resulting in a dramatic loss of farmland biodiversity. The Corn Bunting Emberiza calandra is considered a suitable indicator for the conservation value of farmland habitats, and has recently suffered strong declines throughout much of its European range. As a basis for targeted conservation measures, we investigated the habit
The tropical carbon balance dominates year-to-year variations in the CO2 exchange with the atmosphere through photosynthesis, respiration and fires. Because of its high correlation with gross primary productivity (GPP), observations of sun-induced fluorescence (SIF) are of great interest. We developed a new remotely sensed SIF product with improved signal-to-noise in the tropics, and use it here t
