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Introduction: There is little information on the late stages of parkinsonism. Methods: We conducted a multicentre study in 692 patients with late stage parkinsonism in six European countries. Inclusion criteria were disease duration of ≥7 years and either Hoehn and Yahr stage ≥4 or Schwab and England score of 50 or less. Results: Average disease duration was 15.4 (SD 7.7) years and mean total UPDR

Dynamic decision-making in aviation involves complex problem solving in a dynamic environment characterized by goal conflicts and time constrains. Training mostly focuses on testing domain-specific knowledge and skills that may result in context-specific rather than general problem-solving skills. A low-fidelity decision-making simulation may favour the understanding of the decision process rather

Water in a full-scale drinking water treatment plant was irradiated with ultraviolet (UV) doses of 250, 400, and 600 J/m2, and the effect on bacterial communities investigated using 16s rRNA gene amplicon sequencing, heterotrophic plate counts (HPCs), coliform, and Escherichia coli counts. The bacteria in the irradiated water were also analyzed following storage for 6 days at 7 °C, to approximate

Photocatalytic water splitting has become a promising strategy for converting solar energy into clean and carbon-neutral solar fuels in a low-cost and environmentally benign way. Hydrogen gas is such a potential solar fuel/energy carrier. In a classical artificial photosynthetic system, a photosensitizer is generally associated with a co-catalyst to convert photogenerated charge into (a) chemical

Many hypotheses attempt to explain parasite–host associations, but rarely are they examined together in a single community. For hosts, key traits are the proportion of infected individuals (prevalence) and the diversity of parasites infecting them. A key parasite trait is host specificity, ranging from specialists infecting one or a few closely related species to generalists infecting many species

The retail sector represents 11% of the GDP and employs 15% of the workforce in the European Union. To tackle growth of e-commerce, physical retail stores need to be reviewed; both to decrease operating costs, increase productivity and to make the shopping experience more appealing. Energy use for lighting accounts for 50% of the total energy use in non-food retail stores, which is consumed primar

Kraven på beredning av lagstiftning är en central del i det svenska konstitutionella systemet. I ett större perspektiv kan man se dessa krav som ett uttryck för en mer allmän offentligrättslig princip om beredning av beslut. Mot denna bakgrund behandlar artikeln universitetens och de juridiska fakulteternas roll i lagberedningen som remissinstanser. Utifrån författarens erfarenheter lämnas några s

På nuvarande Kyrkogatans östra sida, strax söder om universitetshusets sydfasad där den gamle zoologen Sven Nilssons byst i dag reser sig på sin höga sockel, där låg i äldre tider ett numera helt försvunnet kvarter, tomten nr 21 i Krafts rote enligt staden Lunds dåvarande tomtindelning. Det var en tomt med en i många avseenden stolt akademisk och kulturell historia, men när den under 1800-talets s

Stromal tumor-infiltrating lymphocytes (sTILs) are a potential predictive biomarker for immunotherapy response in metastatic triple-negative breast cancer (TNBC). To incorporate sTILs into clinical trials and diagnostics, reliable assessment is essential. In this review, we propose a new concept, namely the implementation of a risk-management framework that enables the use of sTILs as a stratifica

The four-year NATURVATION project (2016-2020), funded through the EU Horizon 2020 Programme, seeks to map and analyse existing experiences and practices in the use of nature-based solutions (NBS) to understand what enables NBS innovations and ultimately use this knowledge to inform policy and practice. One of the tasks of the project was to analyse the processes, mechanisms and tools which support

BACKGROUND: Group A streptococci (GAS) are known to cause serious invasive infections, but little is known about outcomes when patients with these infections are admitted to intensive care. We wanted to describe critically ill patients with severe sepsis or septic shock due to invasive GAS (iGAS) and compare them with other patients with severe sepsis or septic shock. METHODS: Adult patients admit

A boundary integral equation formulation is presented for the electromagnetic transmission problem where an incident electromagnetic wave is scattered from a bounded dielectric object. The formulation provides unique solutions for all wavenumbers in the closed upper half-plane belonging to argument sets for which Maxwell's equations have unique solutions. This includes the challenging combination