Filtyp
The aim of this thesis was to study protein-ligand interactions in the binding pocket of galectin-3C and galectin-8N through X-ray crystallography. Ligands in different stages of their development state were crystallized in complex with their respective target protein. In total, two protein-ligand complexes were structurally solved for galectin-3C, and one partially for galectin-8N. The structures
The integration of renewable energy sources such as solar and wind power is steadily increasing, which introduces challenges such as voltage fluctuations, reduced system stability, and lower power quality. Battery Energy Storage Systems (BESS) can support the grid by providing services such as frequency regulation and peak shaving, contributing to a more stable and energy-efficient power system.
This thesis studies the flood risks in Yogyakarta City, Indonesia, focusing on the Kali Belik River area, and explores the regulations and design principles aimed at enhancing flood risk reduction and management in the city. The discussion begins at the global level, analysing frameworks such as the Sendai Framework for Disaster Risk Reduction, and transitions to the local level, assessing the cha
Insect populations have decreased dramatically the past decades, with one reason being unintentional pressure from pesticides. Insecticides such as neonicotinoids can cause sub-lethal effects in insects, such as altered metabolic regulation, which can be studied using targeted metabolomics. Although commonly studied using High-Performance Liquid Chromatography tandem Mass Spectrometry (HPLC-MS/MS)
Chronic respiratory diseases, such as asthma, represent a significant global health issue. Symptoms are commonly treated through inhalation therapy, enabling the delivery of the active pharmaceutical ingredient (API) directly to the lungs. Pulmonary drug delivery offers several advantages, including reduced risk of systemic side effects and a minimally invasive route of administration. Dry-powder
The multidisciplinary Green Extraction approach has recently advanced by integrating the principles of Green Chemistry and the Circular Economy. In this framework, waste products are redefined as negative-cost raw materials for the recovery of high-value compounds with cross-sectoral applications, contributing to both economic and environmental sustainability. This study focuses on the valorizatio
Modern medicine is rapidly evolving toward personalized treatments, where therapies are tailored to an individual’s genetic profile. This shift is driven by the promise of pharmacogenomics, which aims to match patients with the most effective medications based on their unique biological makeup. As a result, biotherapeutics made from biological sources like proteins, peptides, and antibodies are be
The installation of large-scale solar farms is expected to increase in the future as part of a widespread transition from fossil fuel-based energy generation to renewables. By simulating large-scale solar farms in Earth system models (ESMs), previous studies have found that solar farms, at a large enough scale, can globally affect Earth’s climate. This study builds upon previous studies where an E
Society's view of social services has deteriorated with the cause of disinformation and violence from clients on social media. Previous research shows that it has become increasingly common for social workers and their relatives to be exposed to threats and abuse online. Therefore, this study aims to investigate social workers' experiences and attitudes towards being mentioned on social me
Practical and structural changes alone are not enough to achieve sustainable transformation of food systems because they are influenced by people’s underlying inner dimensions. Using data from quantitative student surveys and semi-structured interviews with school workers, this study applies three spheres of transformation framework and explores what place Estonian adolescents’ inner dimensions (v
Rapporten undersöker hur brusreducering påverkar ljudklassificering. Olika aspekter undersöks; informationsbevarande, hur bra brusreduceringen blir, samt brusnivåers och antalet klassers inverkan. Ljudklassificering är när en dator analyserar ljud och identifierar vilka klasser ljudet tillhör. För att skapa klassificering med maskininlärning, tränas ett nätverk att till bästa förmåga klassificerIt is often impossible to capture the sound one wants without capturing noise. Consequently, research has been done on noise filtering in audio signals. Currently deep learning algorithms are used for noise filtering. This thesis investigated the effects of noise and denoising on sound classification. The thesis used two standard datasets for clean sound and noise. FSD50K was chosen as clean soun
Modern vetenskap och teknik är starkt beroende av avancerade datorsimuleringar för att lösa komplexa problem, till exempel inom klimatmodellering eller flygteknik. Dessa simuleringar kan dock vara extremt beräkningskrävande, särskilt när man måste följa systemets utveckling över lång tid. I denna avhandling utvecklar vi en ny metod för att skapa förenklade modeller som behåller noggrannheten hos dReduced-order models (ROMs) have become indispensable tools for reducing the computational complexity of high-fidelity simulations in science and engineering. In this thesis, we introduce a novel training framework that combines the integral form of Operator Inference (OpInf ) with adjoint-state methods to yield robust, data-driven ROMs. By formulating a continuous-time loss functional that integr
Attitudes of Gen Z and their role in the workplace have been widely studied in the past decades. Even though Gen Z and Millennials have some similar workplace attitudes, the rapid change in technology experienced by Gen Z has inculcated some very unique working attitudes in the new generation, which in turn has impacted their expectations of middle management and their preference for such role
Denna studie undersöker förekomsten av Accrual Earnings Management (AEM), mätt genom diskretionära periodiseringar, i svenska börsnoterade företag inom hälso-, teknik-, industri- och konsumentsektorerna, före och efter Covid-19-pandemin. Med hjälp av en deduktiv kvantitativ ansats och den modifierade Jonesmodellen analyseras 3 213 observationer från 682 företag under tidsperioderna 2017–2019 och 2This study examines the presence of Accrual Earnings Management (AEM), measured through discretionary accruals, in Swedish listed companies within the health care, technology, industrial, and consumer sectors before and after the Covid-19 pandemic. Using a deductive quantitative approach and the modified Jones model, the analysis includes 3,213 observations from 682 companies during the periods 20
This thesis explores how inclusive biodiversity governance can deliver socially and environmentally beneficial outcomes, focusing on the role of NGOs and CSOs in facilitating participation by local communities and Indigenous Peoples in Kenya. Drawing on qualitative interviews, project documents, and media content, the study explores what strategies are used to foster participation in a project by
Proteomic analysis can reveal substantial information about cells and cell types, including biomarkers that can be used to distinguish subpopulations. Established protocols include manual pipetting steps of cells that are both time consuming and problematic in terms of samples losses. In this study, a new “FACS-into-evotip” protocol for proteomic analysis was evaluated with the goal to automate sa
The purpose of this thesis is to investigate the potential of transmitting data symbols alongside permuted copies in a repetition coding-like scheme, called the permutation scheme. First exhaustive search is conducted for small constellation sizes to identify possible patterns. The next step was identifying local search methods for permutations, and other methods for longer chains of permutations
With the increasing share of renewable energy sources in the energy system, an increased demand for stabilizing the grid frequency has grown, suggesting a future need for balancing services, such as manual Frequency Restoration Reserve (mFRR). A promising actor able to offer such balancing service is combined heat and power (CHP) plants due to their dispatchable power capabilities. This thesis aim
