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The aim of this investigation was to assess the Ku70/Ku80 complex as a potential target for antibody imaging of prostate cancer. We evaluated the in vivo and ex vivo tumor targeting and biodistribution of the (111)In-labeled human internalizing antibody, INCA-X ((111)In-DTPA-INCA-X antibody), in NMRI-nude mice bearing human PC-3, PC-3M-Lu2 or DU145 xenografts. DTPA-conjugated, non-labeled antibody

Age is the most important risk factor known for cardiovascular disease manifestations. However, the biological ageing of an individual may be substantially different from the chronological age in what has been called “differential ageing”. This process can be evaluated by arterial stiffness (pulse wave velocity), and the marker of telomere length and by levels of telomerase enzymatic activity. Sev

Seven mols. isolated from lichen species were tested as antioxidants and photoprotectors of UV-B (280-315 nm.) radiation. Perlatolic acid was the best of these seven mols. The decarboxythamnolic, usnic and usnic acid deriv. showed activity as photoprotectors. Finally, thamnolic acid showed good scavenging activity.

OBJECTIVES: The susceptibility to arsenic (As)-induced diseases differs greatly between individuals, probably to a large extent due to genetic differences in arsenic metabolism. The aim for this study was to identify genetic variants affecting arsenic metabolism. METHODS: We evaluated the association between urinary metabolite pattern and polymorphisms in three gene-groups related to arsenic metab

Taking its starting point from a critical dialogue with feminist and postcolonial theory, this dissertation explores processes of othering in a feminist adult educational institution, Women’s Room, in Sweden. Women’s Room is a women-only school and half of the student body has a migrant background. The project is an ethnographic study consisting of nine months of participant observations and inter

Cholesterol-rich clusters of SNARE (soluble NSF attachment protein receptor) proteins have been implicated as being important for exocytosis. Here we demonstrate the significance of cholesterol for normal biphasic insulin secretion in mouse beta cells by removal of cholesterol from the plasma membrane using methyl-beta-cyclodextrin (MBCD). Maximal inhibition of insulin secretion in static incubati

BACKGROUND: Health-care costs for hand and forearm injuries in young children are poorly documented. We examined costs in 533 children injured years 1996-2003. METHODS: Health-care costs and costs for lost productivity were retrospectively calculated in children from three catchment areas in Sweden. Seven case categories corresponding to alternative prevention strategies were constructed. RESULTS:

AIM: To investigate the association between political trust (an aspect of institutional trust) and self-rated health, taking generalized (horizontal) trust in other people into account. METHODS: The 2004 public health survey in Skåne is a cross-sectional postal questionnaire study answered by 27,963 respondents aged 18-80 years, yielding a 59% response rate. A logistic regression model was used to

In this paper a robust method is presented for the combined design of STATCOM and Power System Stabilizer (PSS) controllers in order to enhance the damping of the low frequency oscillations in power systems. The combined design problems among PSS and STATCOM internal ac and dc voltage controllers has been taken into consideration. The equations that describe the proposed system have been linearize

The possible contribution of HLA-DRB3, -DRB4 and -DRB5 alleles to type 1 diabetes risk and to autoantibodies against insulin (IAA), GAD65 (GADA), IA-2 (IA-2A) or ZnT8 against either of the three amino acid variants, R, W or Q at position 325 (ZnT8RA, ZnT8WA, and ZnT8QA, respectively) at clinical diagnosis is unclear. Next generation sequencing (NGS) was therefore used to determine all DRB alleles

Doctors are expected to serve the patient in an unbiased and medically accurate manner. Yet, this does not prevent doctors and other medical staff from having pronounced views on whether the patient deserves care. Based on field notes from a cardiology clinic, this contradiction is discussed and analyzed. In directing the spotlight on what circumstances are pointed out by the staff when discussing